Performance qualification of an electronic tongue based on ICH guideline Q2

Woertz, Katharina; Tissen, Corinna; Kleinebudde, Peter; Breitkreutz, Jörg

doi:10.1016/j.jpba.2009.09.029

Cited by 92 publications

(61 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1a) The TS-5000Z e-tongue system (abbreviation: I) was equipped with the commercially available sensors SB2AC0, SB2AN0 and SB2BT0 (dedicated to bitter cationic substances), SB2AAE (dedicated to umami), SB2CT0 (dedicated to saltiness) and SB2CA0 (dedicated to sourness), SB2C00 (dedicated to bitter anionic substances) and SB2AE1 (dedicated to astringent substances) and Ag/AgCl-reference electrode. The measurement followed the standard procedure as described by Woertz et al [22,25], using the recommended measurement setup ABCABC (A, B, and C are representatives of sample beakers). Prior to each measurement, a sensor check was performed and only proper working sensors were applied further.…”

Section: 3mentioning

confidence: 99%

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Pein

Kirsanov

Ciosek

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

a b s t r a c tElectronic tongue technology based on arrays of cross-sensitive chemical sensors and chemometric data processing has attracted a lot of researchers' attention through the last years. Several so far reported applications dealing with pharmaceutical related tasks employed different e-tongue systems to address different objectives. In this situation, it is hard to judge on the benefits and drawbacks of particular e-tongue implementations for R&D in pharmaceutics. The objective of this study was to compare the performance of six different e-tongues applied to the same set of pharmaceutical samples. For this purpose, two commercially available systems (from Insent and AlphaMOS) and four laboratory prototype systems (two potentiometric systems from Warsaw operating in flow and static modes, one potentiometric system from St. Petersburg, one voltammetric system from Barcelona) were employed. The sample set addressed in the study comprised nine different formulations based on caffeine citrate, lactose monohydrate, maltodextrine, saccharin sodium and citric acid in various combinations. To provide for the fair and unbiased comparison, samples were evaluated under blind conditions and data processing from all the systems was performed in a uniform way. Different mathematical methods were applied to judge on similarity of the e-tongues response from the samples. These were principal component analysis (PCA), RV matrix correlation coefficients and Tuckerís congruency coefficients.

show abstract

Section: 3mentioning

confidence: 99%

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Pein

Kirsanov

Ciosek

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

show abstract

“…The performance of the test sensing system has been validated based on ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) guideline Q2. 17 Because the intensity of the basic tastes is expressed as relative values, we used a single brand of commercial bovine milk (Megamilk; Nippon Milk Community Co. Ltd., Tokyo, Japan) as the standard. Thus, negative values for basic taste mean that the intensity of the basic taste was weaker for human than for bovine milk.…”

Section: Evaluation Of Milk Taste By a Taste Sensormentioning

confidence: 99%

Taste of Milk from Inflamed Breasts of Breastfeeding Mothers with Mastitis Evaluated Using a Taste Sensor

Yoshida

Shinohara

Sugiyama

et al. 2014

Breastfeeding Medicine

View full text Add to dashboard Cite

Background: The refusal of infants to suckle from a breast that is inflamed with mastitis suggests that the taste of the milk has changed. However, the taste of milk from a breast with mastitis has never been empirically determined. The present study compares the taste of milk from breastfeeding mothers with or without mastitis and identifies specific changes in the taste of milk from mothers with mastitis. Subjects and Methods: The intensity of four basic tastes (sourness, saltiness, bitterness, and umami) of breastmilk from 24 healthy mothers at 3-5 days and at 2-3, 4-5, and 8-10 weeks postpartum and from 14 mothers with mastitis was determined objectively using a taste sensor. The intensity of each basic taste and the concentrations of main taste substances in milk were compared between the inflamed breasts and the normal breasts of control mothers or the contralateral asymptomatic breast of mothers with unilateral mastitis. Results: The transition from colostrum to mature milk was accompanied by changes in the taste of the milk, such as decreased saltiness and umami and increased bitterness and sourness. Umami and saltiness increased in milk from inflamed breasts. Contents of sodium, glutamate, and guanosine monophosphate increased in milk from inflamed breasts. Conclusions: Tastes that were specifically associated with inflamed breasts appeared to include an increase in umami and saltiness, which might have resulted from an increased content in factors associated with umami and sodium.

show abstract

“…The "electronic tongue" can be incorporated here in formulation development. The electronic tongue is a device which detects an electronic signal in a given formulation; the goal is to achieve an electronic signal of the formulation containing the active drug which is similar to formulation containing a placebo (25)(26)(27). A recent paper describes the use of the electronic tongue in formulating a palatable sodium phenylbutyrate preparation, an extremely difficult task (28).…”

Section: Palatability and Taste Maskingmentioning

confidence: 99%

A Report from the Pediatric Formulations Task Force: Perspectives on the State of Child-Friendly Oral Dosage Forms

Zajicek

Fossler

Barrett

et al. 2013

AAPS J

View full text Add to dashboard Cite

Abstract. Despite the fact that a significant percentage of the population is unable to swallow tablets and capsules, these dosage forms continue to be the default standard. These oral formulations fail many patients, especially children, because of large tablet or capsule size, poor palatability, and lack of correct dosage strength. The clinical result is often lack of adherence and therapeutic failure. The American Association of Pharmaceutical Scientists formed a Pediatric Formulations Task Force, consisting of members with various areas of expertise including pediatrics, formulation development, clinical pharmacology, and regulatory science, in order to identify pediatric, manufacturing, and regulatory issues and areas of needed research and regulatory guidance. Dosage form and palatability standards for all pediatric ages, relative bioavailability requirements, and small batch manufacturing capabilities and creation of a viable economic model were identified as particular needs. This assessment is considered an important first step for a task force seeking creative approaches to providing more appropriate oral formulations for children.

show abstract

Performance qualification of an electronic tongue based on ICH guideline Q2

Cited by 92 publications

References 18 publications

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Taste of Milk from Inflamed Breasts of Breastfeeding Mothers with Mastitis Evaluated Using a Taste Sensor

A Report from the Pediatric Formulations Task Force: Perspectives on the State of Child-Friendly Oral Dosage Forms

Contact Info

Product

Resources

About