Performance of yeast-like cell counting (YLCC) using the Sysmex UF-1000i for clinical candiduria screening

He, Zhengxin; Zhang, Hai-pu; Cheng, Yan; Xiang-yang, Ran; Chen, Jing; Huo, Xiaosai; Wang, Fukun

doi:10.1007/s10096-019-03491-5

Cited by 1 publication

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that this parameter has the potential to screen candiduria patients efficiently. 13,15,16 Particularly, this prospective study was primarily designed to answer the combination of YLCC and urine microbial culture can achieve the rapid and effective identification of candiduria and Candida species. The screening protocol improved the candiduria diagnostic rate ranged from 2.28% to 17.27% in ICU, which is consistently similar to our previous retrospective analysis.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12] Our previous work showed that YLCC is suitable for identifying urines with relatively high Candida CFUs. 13 YLCCpositive urinalysis could imply candiduria prior to urine culture, especially the persistent positive YLCC cases. However, YLCC of urinalysis alone cannot provide sufficient information for candiduria managing, such as the Candida species identification and yeast susceptibility test.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

He¹,

Su²,

Bi³

et al. 2021

IDR

View full text Add to dashboard Cite

Background: Since urine cultures are only guaranteed for patients with obvious urinary symptoms in most cases, most of candiduria episodes are ignored in clinic. Objective: This study aimed to design a screening protocol to improve diagnostic efficiency of candiduria, and provide information of Candida species and drug susceptibility. Methods: All patients, who were admitted to the intensive care unit (ICU) of our hospital during December 1, 2018 and October 1, 2019, were enrolled in this study. Urinalysis was performed every three days for each subject from the first day of ICU admission. Urine specimens were sampled for fungal culture with either condition: (1) yeast-like cell counting (YLCC) ≥200; (2) positive YLCCs were observed in two consecutive tests, and at least one YLCC ≥100. Results: The screening protocol dramatically improved the candiduria diagnostic rate of ICU patients from 2.28% to 17.27%. However, compared to the historical control, the screening protocol has no time-saving advantage in candiduria diagnosing. Higher percentage of C. albicans in screening protocol-identified candiduria patients was observed, although there was no statistical difference. Our results indicated that female gender, pneumonia, diabetes and infarction/hemorrhage patients were more prone to develop candiduria. Non-candiduria patients showed a better tendency for survival and shorter ICU stay length. Multisite colonization was common in the surveyed candiduria patients, who were up to 70.83% showed Candida positive cultures in sputum. Conclusion: The screening protocol established in the study was a convenient and practical tool for early warning and feasible management of candiduria and IC.

show abstract

Section: Discussionmentioning

confidence: 99%