Performance of sofosbuvir and NITD008 in extrahepatic neuronal cells against HEV

Jagst, Michelle; Gömer, André; Todt, Daniel; Steinmann, Eike

doi:10.1016/j.antiviral.2024.105922

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…In addition, a related antiviral agent, Adefovir dipivoxyl, has been found to be the antiviral strategy of choice for the treatment of hepatitis B-induced decompensated cirrhosis ( Zhang et al, 2017 ). And there is also a prospective new study ( Jagst et al, 2024 ) that found that hepatitis E tends to convert to chronic infection in immunocompromised patients, and that sofosbuvir is effective in inhibiting hepatitis E virus replication, especially in extrahepatic neuronal cells. ii) Anti-inflammatory and anti-fibrosis therapy should be considered in some patients with cirrhosis for whom etiological therapy is not available, or for whom liver inflammation or fibrosis remains severe after etiological therapy.…”

Section: Treatment Of Liver Cirrhosis Using Modern Medicinementioning

confidence: 99%

Liver cirrhosis: current status and treatment options using western or traditional Chinese medicine

Zheng,

Xue,

et al. 2024

Front. Pharmacol.

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Liver cirrhosis arises from liver fibrosis and necroinflammation caused by various mechanisms of hepatic injury. It is a prevalent condition in clinical practice characterized by hepatocellular dysfunction, portal hypertension, and associated complications. Despite its common occurrence, the etiology and pathogenesis of liver cirrhosis remain incompletely understood, posing a significant health threat. Effective prevention of its onset and progression is paramount in medical research. Symptoms often include discomfort in the liver area, while complications such as sarcopenia, hepatic encephalopathy, ascites, upper gastrointestinal bleeding, and infection can arise. While the efficacy of Western medicine in treating liver cirrhosis is uncertain, Chinese medicine offers distinct advantages. This review explores advancements in liver cirrhosis treatment encompassing non-pharmacological and pharmacological modalities. Chinese medicine interventions, including Chinese medicine decoctions, Chinese patent medicines, and acupuncture, exhibit notable efficacy in cirrhosis reversal and offer improved prognoses. Nowadays, the combination of Chinese and Western medicine in the treatment of liver cirrhosis also has considerable advantages, which is worthy of further research and clinical promotion. Standardized treatment protocols based on these findings hold significant clinical implications.

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Section: Treatment Of Liver Cirrhosis Using Modern Medicinementioning

confidence: 99%

Liver cirrhosis: current status and treatment options using western or traditional Chinese medicine

Zheng,

Xue,

et al. 2024

Front. Pharmacol.

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From discovery to treatment: tracing the path of hepatitis E virus

Letafati,

Taghiabadi,

Roushanzamir

et al. 2024

Virol J

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The hepatitis E virus (HEV) is a major cause of acute viral hepatitis worldwide. HEV is classified into eight genotypes, labeled HEV-1 through HEV-8. Genotypes 1 and 2 exclusively infect humans, while genotypes 3, 4, and 7 can infect both humans and animals. In contrast, genotypes 5, 6, and 8 are restricted to infecting animals. While most individuals with a strong immune system experience a self-limiting infection, those who are immunosuppressed may develop chronic hepatitis. Pregnant women are particularly vulnerable to severe illness and mortality due to HEV infection. In addition to liver-related complications, HEV can also cause extrahepatic manifestations, including neurological disorders. The immune response is vital in determining the outcome of HEV infection. Deficiencies in T cells, NK cells, and antibody responses are linked to poor prognosis. Interestingly, HEV itself contains microRNAs that regulate its replication and modify the host's antiviral response. Diagnosis of HEV infection involves the detection of HEV RNA and anti-HEV IgM/IgG antibodies. Supportive care is the mainstay of treatment for acute infection, while chronic HEV infection may be cleared with the use of ribavirin and pegylated interferon. Prevention remains the best approach against HEV, focusing on sanitation infrastructure improvements and vaccination, with one vaccine already licensed in China. This comprehensive review provides insights into the spread, genotypes, prevalence, and clinical effects of HEV. Furthermore, it emphasizes the need for further research and attention to HEV, particularly in cases of acute hepatitis, especially among solid-organ transplant recipients.

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Performance of sofosbuvir and NITD008 in extrahepatic neuronal cells against HEV

Cited by 2 publications

References 24 publications

Liver cirrhosis: current status and treatment options using western or traditional Chinese medicine

Liver cirrhosis: current status and treatment options using western or traditional Chinese medicine

From discovery to treatment: tracing the path of hepatitis E virus

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