2021
DOI: 10.1016/j.ijid.2021.04.087
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Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals

Abstract: Screening, testing and contact tracing plays a pivotal role in control of the COVID-19 pandemic. To enable this it is necessary to increase the testing capacity. This study compared a SARS-CoV-2 rapid antigen test (RAT) and RT-PCR in 842 asymptomatic individuals from Tarapacá, Chile. A sensitivity of 69.86%, specificity of 99.61%, PPV of 94.44% and NPP of 97.22% with Ct values (Ct > 27) that were significantly higher among individuals with false-negative RAT were reported. These results support the fact that R… Show more

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Cited by 58 publications
(43 citation statements)
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“…At the end of the data extraction process, 37 studies were still in preprint form [4,171,173,174,177,180,190,192,201,204,205,207,211,[214][215][216]218,220,222,223,225,227,231,233,234,238,240,244,247,253,257,265,267,284,287,290,293]. All studies were written in English, except for 2 in Spanish [175,280].…”
Section: Summary Of Studiesmentioning
confidence: 99%
“…At the end of the data extraction process, 37 studies were still in preprint form [4,171,173,174,177,180,190,192,201,204,205,207,211,[214][215][216]218,220,222,223,225,227,231,233,234,238,240,244,247,253,257,265,267,284,287,290,293]. All studies were written in English, except for 2 in Spanish [175,280].…”
Section: Summary Of Studiesmentioning
confidence: 99%
“…Eighteen studies with 34,865 participants were retrieved [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Figure 1 depicts the process of the literature search, and Table 1 presents detailed characteristics of the studies.…”
Section: Resultsmentioning
confidence: 99%
“…Though helpful, the limitations of these kits should be noted by the users. Some studies have suggested low sensitivity in screening asymptomatic patients ( Eshghifar et al, 2021 ; Peña et al, 2021 ; Torres et al, 2021 ). Various authors have cited lower sensitivity in patients with low viral load (high Ct values on RT-PCR); hence RT-PCR testing should continue to be offered where clinical suspicion is high( Ebrahimi et al, 2021 ; Nalumansi et al, 2021 ; Peeling et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%