Capacity of components subjected to earthquake actions is still a widely interesting research topic. Hence, developing precise tools for predicting drift capacities of reinforced concrete (RC) columns is of great interest. RC columns are not only frequently constructed, but also their composite behavior makes the capacity prediction a task faced with many uncertainties. In the current article, novel empirical approaches are presented for predicting flexural, shear and axial failure modes in RC columns. To this aim, an extensive experimental database was created by collecting outcomes of previously conducted experimental tests since 1964, which are available in the literature. It serves as the basis for deriving the equations for predicting the drift capacity of RC columns by different regression analyses (both linear with different orders and nonlinear). Furthermore, fragility curves are determined for comparing the obtained results with the experimental results and with previously proposed models, like the ones of ASCE/SEI 41-13. It is demonstrated that the proposed equations predict drift capacities, which are in better agreement with experimental results than those computed by previously published models. In addition, the reliability of the proposed equations is higher from a probabilistic point of view.