Performance of rapid HIV testing using Determine<sup>®</sup> HIV-1/2 for the diagnosis of HIV infection during pregnancy in Tijuana, Baja California, Mexico

Viani, Rolando M.; Hubbard, Patricia; Ruiz-Calderon, Jorge; Araneta, Maria Rosario G.; López, Gladys Galvis; Chacón-Cruz, Enrique; Spector, Stephen A.

doi:10.1258/095646207779949655

Cited by 7 publications

(4 citation statements)

References 10 publications

(14 reference statements)

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“…It is a lateral flow assay with a 15-minute turnaround time. The Determine HIV-1/2 rapid test used has demonstrated 100% sensitivity and 99.8% specificity in pregnancy [14]. A second rapid HIV test (the First Response HIV Card Test) was performed on antenatal patients who had a positive Determine test.…”

Section: Methodsmentioning

confidence: 99%

Hepatitis B, HIV, and Syphilis Seroprevalence in Pregnant Women and Blood Donors in Cameroon

Dionne-Odom

Mbah

Rembert

et al. 2016

Infectious Diseases in Obstetrics and Gynecology

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Objectives. We estimated seroprevalence and correlates of selected infections in pregnant women and blood donors in a resource-limited setting. Methods. We performed a cross-sectional analysis of laboratory seroprevalence data from pregnant women and voluntary blood donors from facilities in Cameroon in 2014. Rapid tests were performed to detect hepatitis B surface antigen, syphilis treponemal antibodies, and HIV-1/2 antibodies. Blood donations were also tested for hepatitis C and malaria. Results. The seroprevalence rates and ranges among 7069 pregnant women were hepatitis B 4.4% (1.1–9.6%), HIV 6% (3.0–10.2%), and syphilis 1.7% (1.3–3.8%) with significant variability among the sites. Correlates of infection in pregnancy in adjusted regression models included urban residence for hepatitis B (aOR 2.9, CI 1.6–5.4) and HIV (aOR 3.5, CI 1.9–6.7). Blood donor seroprevalence rates and ranges were hepatitis B 6.8% (5.0–8.8%), HIV 2.2% (1.4–2.8%), syphilis 4% (3.3–4.5%), malaria 1.9%, and hepatitis C 1.7% (0.5–2.5%). Conclusions. Hepatitis B, HIV, and syphilis infections are common among pregnant women and blood donors in Cameroon with higher rates in urban areas. Future interventions to reduce vertical transmission should include universal screening for these infections early in pregnancy and provision of effective prevention tools including the birth dose of univalent hepatitis B vaccine.

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Section: Methodsmentioning

confidence: 99%

Hepatitis B, HIV, and Syphilis Seroprevalence in Pregnant Women and Blood Donors in Cameroon

Dionne-Odom

Mbah

Rembert

et al. 2016

Infectious Diseases in Obstetrics and Gynecology

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“…To date, numerous research studies conducted in developed (i.e., USA and Canada) and developing (i.e., Brazil, Mexico, Cameroon, Russia, Rwanda, Nigeria, Uganda, Zambia, Peru and India) settings have demonstrated successful implementation of a rapid HIV testing program in labor and delivery [19–28].…”

Section: Barriers To Seeking Testing and Counseling Services In Pregnanmentioning

confidence: 99%

Rapid Testing at Labor and Delivery to Prevent Mother-To-Child Hiv Transmission in Developing Settings: Issues and Challenges

Pai

Klein

2009

Womens Health (Lond Engl)

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Worldwide, approximately 2.5 million children (95% CI: 2.2-2.6) are living with HIV infection. In 2007 alone, approximately 420,000 children (95%CI: 350,000-540,000) were newly infected with HIV - a vast majority of these infections were acquired through maternal-fetal transmission. Many of these infections could have been reduced by timely diagnosis and the delivery of interventions aimed at preventing mother-to-child HIV transmission. This perspective examines the attitudes preventing women from accessing HIV testing early on during pregnancy and the issues and challenges that remain in the institutionalization of interventions to prevent mother-to-child HIV transmission at labor and delivery. Socio-cultural and economic factors prevent women from accessing testing at an opportune time during pregnancy. In addition, a lack of adequate infrastructure often prevents timely delivery of interventions to those who access testing at the last minute (i.e., during labor and delivery). In the wake of a pediatric HIV epidemic and the need for lifelong provision of antiretroviral therapy to infected children, a simple strategy for provision of round-the-clock rapid testing and counseling services in the labor rooms may be cost saving to the healthcare systems worldwide.

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“…[21] Rapid testing has been conducted in parks, shelters, syringe exchanges, community clinics, VCT programmes and antenatal clinics. [21-25] The performance of algorithms employing several different POCTs either in consecutive or parallel testing strategies has also been reported, with varying outcomes. One field evaluation suggested that different combinations of POCTs provided sensitivity and specificity similar to standard enzyme immunoassays and Western Blot.…”

Section: Introductionmentioning

confidence: 99%

“…[22] Another study evaluating the performance of the Determine HIV-1/2 in pregnant women in Mexico reported high sensitivity and specificity, though a lower positive predictive value associated with the low prevalence of anti-HIV in this population. [25] Another study reported successful implementation of rapid HIV testing in several different types of community settings but only measured the positive predictive value for those receiving confirmatory tests after testing anti-HIV positive on the rapid HIV assay. [21] A study employing the Determine and Uni-Gold rapid HIV test assays in Uganda reported good sensitivity, though specificity was compromised because of the occurrence of weak reactions with the test band.…”

Section: Introductionmentioning

confidence: 99%

Improving survey methods in sero-epidemiological studies of injecting drug users: a case example of two cross sectional surveys in Serbia and Montenegro

et al. 2009

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BackgroundLittle is known about the prevalence of HIV or HCV in injecting drug users (IDUs) in Serbia and Montenegro. We measured prevalence of antibodies to HIV (anti-HIV) and hepatitis C virus (anti-HCV), and risk factors for anti-HCV, in community-recruited IDUs in Belgrade and Podgorica, and determined the performance of a parallel rapid HIV testing algorithm.MethodsRespondent driven sampling and audio-computer assisted survey interviewing (ACASI) methods were employed. Dried blood spots were collected for unlinked anonymous antibody testing. Belgrade IDUs were offered voluntary confidential rapid HIV testing using a parallel testing algorithm, the performance of which was compared with standard laboratory tests. Predictors of anti-HCV positivity and the diagnostic accuracy of the rapid HIV test algorithm were calculated.ResultsOverall population prevalence of anti-HIV and anti-HCV in IDUs were 3% and 63% respectively in Belgrade (n = 433) and 0% and 22% in Podgorica (n = 328). Around a quarter of IDUs in each city had injected with used needles and syringes in the last four weeks. In both cities anti-HCV positivity was associated with increasing number of years injecting (eg Belgrade adjusted odds ratio (AOR) 5.6 (95% CI 3.2–9.7) and Podgorica AOR 2.5 (1.3–5.1) for ≥ 10 years v 0–4 years), daily injecting (Belgrade AOR 1.6 (1.0–2.7), Podgorica AOR 2.1 (1.3–5.1)), and having ever shared used needles/syringes (Belgrade AOR 2.3 (1.0–5.4), Podgorica AOR 1.9 (1.4–2.6)). Half (47%) of Belgrade participants accepted rapid HIV testing, and there was complete concordance between rapid test results and subsequent confirmatory laboratory tests (sensitivity 100% (95%CI 59%–100%), specificity 100% (95%CI 98%–100%)).ConclusionThe combination of community recruitment, ACASI, rapid testing and a linked diagnostic accuracy study provide enhanced methods for conducting blood borne virus sero-prevalence studies in IDUs. The relatively high uptake of rapid testing suggests that introducing this method in community settings could increase the number of people tested in high risk populations. The high prevalence of HCV and relatively high prevalence of injecting risk behaviour indicate that further HIV transmission is likely in IDUs in both cities. Urgent scale up of HIV prevention interventions is needed.

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Performance of rapid HIV testing using Determine^® HIV-1/2 for the diagnosis of HIV infection during pregnancy in Tijuana, Baja California, Mexico

Cited by 7 publications

References 10 publications

Hepatitis B, HIV, and Syphilis Seroprevalence in Pregnant Women and Blood Donors in Cameroon

Hepatitis B, HIV, and Syphilis Seroprevalence in Pregnant Women and Blood Donors in Cameroon

Rapid Testing at Labor and Delivery to Prevent Mother-To-Child Hiv Transmission in Developing Settings: Issues and Challenges

Improving survey methods in sero-epidemiological studies of injecting drug users: a case example of two cross sectional surveys in Serbia and Montenegro

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Performance of rapid HIV testing using Determine® HIV-1/2 for the diagnosis of HIV infection during pregnancy in Tijuana, Baja California, Mexico

Cited by 7 publications

References 10 publications

Hepatitis B, HIV, and Syphilis Seroprevalence in Pregnant Women and Blood Donors in Cameroon

Hepatitis B, HIV, and Syphilis Seroprevalence in Pregnant Women and Blood Donors in Cameroon

Rapid Testing at Labor and Delivery to Prevent Mother-To-Child Hiv Transmission in Developing Settings: Issues and Challenges

Improving survey methods in sero-epidemiological studies of injecting drug users: a case example of two cross sectional surveys in Serbia and Montenegro

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Product

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Performance of rapid HIV testing using Determine^® HIV-1/2 for the diagnosis of HIV infection during pregnancy in Tijuana, Baja California, Mexico