Performance of Phonoelectrocardiographic Left Ventricular Systolic Time Intervals and B‐Type Natriuretic Peptide Levels in the Diagnosis of Left Ventricular Dysfunction

Moyers, Brian; Shapiro, Barry A.; Marcus, Gregory M.; Gerber, Ivor L.; McKeown, B.; Vessey, Joshua C.; Jordan, Mark V.; Huddleston, R N Michele; Foster, Elyse; Chatterjee, Meeta; Michaels, Michelle

doi:10.1111/j.1542-474x.2007.00146.x

Cited by 33 publications

(29 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, in patients with a grey-zone brain natriuretic peptide levels (100-500 pg/ mL), an abnormal %EMAT substantially improved the prediction for LV dysfunction (16). In the present study, % EMAT was significantly correlated with LV EF and Ea but not with E/E´.…”

Section: Ematsupporting

confidence: 59%

“…In contrast, patients with heart failure having raised LV filling pressures show a decrease in PEP and PEP/ ET in response to preload reduction (23). On the other hand, recent studies demonstrated that %EMAT was not associated with LV end diastolic pressure (16,25), indicating less preload sensitivity with %EMAT.…”

Section: Ematmentioning

confidence: 83%

“…An abnormal %EMAT (!15) had 44% sensitivity, 94% specificity, and a 7.0 likelihood ratio for the identification of patients with LV dysfunction (LV end-diastolic pressure >15 mmHg and LV EF <50%) (16). In addition, in patients with a grey-zone brain natriuretic peptide levels (100-500 pg/ mL), an abnormal %EMAT substantially improved the prediction for LV dysfunction (16).…”

Section: Ematmentioning

confidence: 99%

See 2 more Smart Citations

Electromechanical Activation Time in the Prediction of Discharge Outcomes in Patients Hospitalized with Acute Heart Failure Syndrome

et al. 2010

View full text Add to dashboard Cite

Objective Left ventricular systolic time intervals, including pre-ejection period (PEP), ejection time (ET), and their ratio (PEP/ET), is determined by systolic and diastolic function and ventriculo-arterial coupling. We investigated the usefulness of the electromechanical activation time [(EMAT) PEP minus isovolumic contraction time] in the prediction of cardiac mortality or re-hospitalization for heart failure in patients with the acute heart failure syndrome (AHFS). Patients and Methods A total of 45 patients (71.9±16.1 years old) hospitalized for AHFS were enrolled. Systolic time intervals and EMAT normalized by cardiac cycle length (%) were measured separately by separate automated acoustic devices. All parameters were assessed within 24 hours of admission, before discharge, and 2 weeks after discharge. Results During a mean follow-up of 242±156 days, 20 patients (44%) incurred adverse cardiovascular events including 18 re-hospitalizations for heart failure and 2 cardiovascular deaths. Using uni-variate Cox regression analysis, at admission %EMAT and %PEP, pre-discharge %EMAT, and post-discharge %EMAT significantly predicted post-discharge cardiovascular events with hazard ratios and 95% confidence intervals of 1.75(1.13-2.70), 1.67(1.02-2.70), 1.87 (1.10-3.17) and 2.50 (1.58-3.97) per 1-SD increment, respectively. The predictions remained significant after adjustment for age, sex, left ventricular ejection fraction, E/E´by Doppler echocardiography, and serum N-terminal pro-brain natriuretic peptide. Conclusion EMAT measured during the hospitalization course is useful in the prediction of cardiovascular outcomes in patients with AHFS independent of left ventricular ejection fraction, E/E´, and serum N-terminal pro-brain natriuretic peptide.

show abstract

Section: Ematsupporting

confidence: 59%

Section: Ematmentioning

confidence: 83%

Section: Ematmentioning

confidence: 99%

See 1 more Smart Citation

Electromechanical Activation Time in the Prediction of Discharge Outcomes in Patients Hospitalized with Acute Heart Failure Syndrome

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In one report, 100 subjects each underwent acoustic cardiography, echocardiography, BNP measurement, and left heart catheterization within a 4‐hour period. These studies demonstrated that there was a strong association between the presence of an S 3 and a number of parameters, including the incidence of HF diagnosis, depressed LV ejection fraction, elevated LV end‐diastolic pressure, abnormal ventricular relaxation, and tissue Doppler imaging assessments indicative of ventricular dysfunction (e.g., increased deceleration rate of early mitral valve inflow patterns) 34,35 . While BNP values performed well in predicting the absence of HF, they fared poorly in predicting depressed LV ejection fraction and elevated LV end‐diastolic pressure.…”

Section: Acoustic Cartography and Its Correlation To Gold Standardsmentioning

confidence: 99%

The Utility of Heart Sounds and Systolic Intervals Across the Care Continuum

Peacock

Harrison

Maisel

2006

Congestive Heart Failure

View full text Add to dashboard Cite

Acoustic cardiography is an exciting, new, easy-to-use, modernized technology that incorporates already proven techniques of phonocardiography. Application of acoustic cardiography to clinical practice can improve diagnosis and management of heart failure patients. Its clinical use should help address some of the need for robust, inexpensive, and widely accessible technology for proactive heart failure diagnosis and management. Acoustic cardiographically recorded measurements have been correlated with both cardiac catheterization and echocardiographically determined hemodynamic parameters. Heart sounds captured by acoustic cardiograms have proven to assist clinicians in assessing dyspneic patients in the emergency department by utilizing the strong specificity of an S3 for detecting acute decompensated heart failure. Acoustic cardiography offers a cost-efficient, easy-to-use method to optimize the devices used in cardiac resyncronization therapy. The rapidly and easily obtainable information gathered by acoustic cardiography should foster its more widespread use in diagnosis and treatment of heart failure, including cardiac resyncronization therapy device optimization.

show abstract

“…Previous studies have shown that acoustic cardiography accurately detects clinical heart failure and specific hemodynamic abnormalities known to be associated with heart failure 3,4 . In particular, the comparison of acoustic cardiography parameters with relevant hemodynamic parameters obtained during left heart catheterization studies have shown that: 1) S 3 strength correlates well with the absolute value of the LV end‐diastolic pressure (LVEDP); 2) a prolonged EMAT is associated with reduced LV maximum contractility; and 3) reduced LVST values correlate to reduced LV ejection fraction (LVEF) in patients with systolic dysfunction 5 …”

mentioning

confidence: 99%

Optimization of Cardiac Resynchronization Devices Using Acoustic Cardiography: A Comparison to Echocardiography

Hasan

Abraham

Quinn‐Tate

et al. 2006

Congestive Heart Failure

View full text Add to dashboard Cite

Optimization of pacemaker settings for cardiac resynchronization therapy (CRT) remains challenging and problematic. Several noninvasive methods are offered to customize the programmed parameters for individual patients, but so far only echocardiographic imaging has established itself as an accepted method. The authors examined the value of acoustic cardiography as a fast and more cost-efficient alternative to established echocardiographic imaging techniques for the optimization of CRT devices. The atrioventricular delay in 22 subjects with implanted CRT devices was independently optimized using echocardiography (Doppler transmitral flow) as well as acoustic cardiography, and the recommended settings from each method were later compared. Doppler echocardiography and acoustic cardiography recommendations matched within a mean value +/- SD of 17+/-16 milliseconds and gave a correlation coefficient of r=0.90 (p<0.001). In 17 of the 22 cases (77.3%), the difference between echocardiographic and acoustic cardiogram CRT optimization results was 20 milliseconds (22.7%). In addition, it took less time for the acoustic cardiogram to collect sufficient information to make a recommendation, and it was found that the acoustic cardiogram data trend is easier to interpret.

show abstract

Performance of Phonoelectrocardiographic Left Ventricular Systolic Time Intervals and B‐Type Natriuretic Peptide Levels in the Diagnosis of Left Ventricular Dysfunction

Cited by 33 publications

References 28 publications

Electromechanical Activation Time in the Prediction of Discharge Outcomes in Patients Hospitalized with Acute Heart Failure Syndrome

Electromechanical Activation Time in the Prediction of Discharge Outcomes in Patients Hospitalized with Acute Heart Failure Syndrome

The Utility of Heart Sounds and Systolic Intervals Across the Care Continuum

Optimization of Cardiac Resynchronization Devices Using Acoustic Cardiography: A Comparison to Echocardiography

Contact Info

Product

Resources

About