Performance of perfusion-weighted Fourier decomposition MRI for detection of chronic pulmonary emboli

Schönfeld, Christian; Cebotari, Serghei; Voskrebenzev, Andreas; Gutberlet, Marcel; Hinrichs, Jan B.; Renne, Julius; Hoeper, Marius M.; Olsson, Karen M.; Welte, Tobias; Wacker, Frank

doi:10.1002/jmri.24764

Cited by 40 publications

(34 citation statements)

References 36 publications

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“…While gas MRI techniques (such as hyperpolarized 129 Xe or 19 F) directly depict the gas distribution typically during breath‐hold, FD MRI uses regional lung motion during normal tidal breathing to calculate regional ventilation. Also, several studies show promising data derived from FD for diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis or chronic thromboembolic pulmonary hypertension, which positions FD as a valuable candidate for clinical translation in the near future …”

Section: Introductionmentioning

confidence: 99%

Free‐breathing quantification of regional ventilation derived by phase‐resolved functional lung (PREFUL) MRI

et al. 2019

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Purpose To test the feasibility of regional fully quantitative ventilation measurement in free breathing derived by phase‐resolved functional lung (PREFUL) MRI in the supine and prone positions. In addition, the influence of T2* relaxation time on ventilation quantification is assessed. Methods Twelve healthy volunteers underwent functional MRI at 1.5 T using a 2D triple‐echo spoiled gradient echo sequence allowing for quantitative measurement of T2* relaxation time. Minute ventilation (ΔV) was quantified by conventional fractional ventilation (FV) and the newly introduced regional ventilation (VR), which corrects volume errors due to image registration. ΔVFV versus ΔVVR and ΔVVR versus ΔVVR with T2* correction were compared using Bland–Altman plots and correlation analysis. The repeatability and physiological plausibility of all measurements were tested in the supine and prone positions. Results On global and regional scales a strong correlation was observed between ΔVFV versus ΔVVR and ΔVVR versus ΔVVRT2* (r > 0.93); however, regional Bland–Altman analysis showed systematic differences (p < 0.0001). Unlike ΔVVRT2*, ΔVVR and ΔVFV showed expected physiologic anterior–posterior gradients, which decreased in the supine but not in the prone position at second measurement during 3 min in the same position. For all quantification methods a moderate repeatability (coefficient of variation <20%) of ventilation was found. Conclusion A fully quantified regional ventilation measurement using ΔVVR in free breathing is feasible and shows physiologically plausible results. In contrast to conventional ΔVFV, volume errors due to image registration are eliminated with the ΔVVR approach. However, correction for the T2* effect remains challenging.

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Section: Introductionmentioning

confidence: 99%

Free‐breathing quantification of regional ventilation derived by phase‐resolved functional lung (PREFUL) MRI

et al. 2019

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“…Although the approach has already shown promise for clinical use in patients, uf‐bSSFP lung imaging is hampered at 3 T by off‐resonance artifacts resulting in nondiagnostic image quality . The aforementioned high‐susceptibility variations in the lung are the main cause of the off‐resonance artifacts.…”

Section: Introductionmentioning

confidence: 99%

Functional lung imaging with transient spoiled gradient echo

Bauman

Pusterla

Bieri

2018

Magnetic Resonance in Med

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Purpose To introduce an alternative framework for perfusion and ventilation lung imaging at 3 T using transient spoiled gradient echo (tSPGR) acquisitions. Methods Sets of coronal 2D time‐resolved lung image series were acquired in 5 healthy volunteers using tSPGR and compared with contemporary SPGR and ultrafast balanced SSFP (uf‐bSSFP) implementations at 1.5 T and 3 T. Sequence parameters and view ordering were optimized for tSPGR to yield maximum signal intensity in the lung tissue. Signal‐to‐noise ratio and contrast‐to‐noise ratio analyses were performed in all acquired tSPGR, SPGR, and uf‐bSSFP data sets. Matrix pencil decomposition was applied to generate functional parameter maps, including fractional ventilation, relative perfusion, and blood arrival time. Results For the lung, the signal intensity of tSPGR imaging was maximal for minimal TR and TE settings of 0.99 ms and 0.43 ms, respectively. Moreover, low RF spoiling increments in combination with a centric view ordering resulted in a further signal‐to‐noise ratio increase of about 30% to 40%. The average signal‐to‐noise ratio in the lung parenchyma was 73.3 for uf‐bSSFP, 38.1 for tSPGR, 20.7 for SPGR at 1.5 T, and 31.2 for uf‐bSSFP, 35.6 for tSPGR, and 21.3 for SPGR at 3 T. The average ventilation and perfusion contrast‐to‐noise ratio was 33.2 and 36.2 for uf‐bSSFP, 15.4 and 12.5 for tSPGR, 13.5 and 4.1 for SPGR at 1.5 T, and 16.5 and 11.3 for uf‐bSSFP, 29.7 and 50.8 for tSPGR, and 22.4 and 16.5 for SPGR at 3 T, respectively. Conclusion At 3 T, application of balanced SSFP is limited, so tSPGR offers an alternative framework for successful lung function assessment using matrix pencil MRI.

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“…Dynamic contrast‐enhanced MRI has been developed to visualize and quantify lung parenchymal perfusion at a regional level with high precision (see above) . Furthermore, perfusion‐weighted Fourier decomposition MRI, is a free breathing method to assess pulmonary parenchymal perfusion (and ventilation) without intravenous contrast administration …”

Section: Introductionmentioning

confidence: 99%

Respiratory tract exacerbations revisited: Ventilation, inflammation, perfusion, and structure (VIPS) monitoring to redefine treatment

Tiddens

Stick

Wild

et al. 2015

Pediatric Pulmonology

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Summary. For cystic fibrosis (CF) patients older than 6 years there are convincing data that suggest respiratory tract exacerbations (RTE) play an important role in the progressive loss of functional lung tissue. There is a poor understanding of the pathobiology of RTE and whether specific treatment of RTE reduces lung damage in the long term. In addition, there are limited tools available to measure the various components of CF lung disease and responses to therapy. Therefore, in order to better understand the impact of RTE on CF lung disease we need to develop sensitive measures to characterize RTE and responses to treatment; and improve our understanding of structure-function changes during treatment of RTE. In this paper we review our current knowledge of the impact of RTE on the progression of lung disease and identify strategies to improve our understanding of the pathobiology of RTE. By improving our knowledge regarding RTE in CF we will be better positioned to develop approaches to treatment that are individualized and that can prevent permanent structural damage. We suggest the development of a ventilation, perfusion, inflammation and structure (VIPS)-MRI suite that supplies the clinician with data on ventilation, inflammation, perfusion, and structure in one MRI session. VIPS-MRI could be an important step to better understand the factors that contribute to and limit treatment efficacy of RTE. Pediatr Pulmonol. 2015;50:S57-S65. ß 2015 Wiley Periodicals, Inc.

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Performance of perfusion-weighted Fourier decomposition MRI for detection of chronic pulmonary emboli

Abstract: Pw-FD of the lung is a feasible test to diagnose chronic PE on a per-patient level during free-breathing without the use of ionizing radiation or contrast agents.

Cited by 40 publications

References 36 publications

Free‐breathing quantification of regional ventilation derived by phase‐resolved functional lung (PREFUL) MRI

Free‐breathing quantification of regional ventilation derived by phase‐resolved functional lung (PREFUL) MRI

Functional lung imaging with transient spoiled gradient echo

Respiratory tract exacerbations revisited: Ventilation, inflammation, perfusion, and structure (VIPS) monitoring to redefine treatment

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