Performance of Pap smear and human papilloma virus testing in the follow‐up of women with cervical intraepithelial neoplasia grade 1 managed conservatively

Santos, André Luis Ferreira; Derchain, Sophie; Sarian, Luís Otávio; Martins, Marcos Roberto; Morais, Sirlei Siani; Syrjänen, Karí

doi:10.1080/00016340600604682

Cited by 10 publications

(3 citation statements)

References 24 publications

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“…This resulted in 125 studies being excluded. The remaining 89 studies were included for meta-analysis, of which 63 studies with CIN 1 patients, 8–70 42 studies with CIN 2 patients, 11,26,27,35–37,39,41–44,50,52,53,57,69–95 and 7 studies with CIN 3 patients 3,26,41,72,81,83,88 . The characteristics and the follow-up protocol of the included studies are summarized in Supplementary Tables 1–3, http://links.lww.com/LGT/A239, http://links.lww.com/LGT/A240, http://links.lww.com/LGT/A241.…”

Section: Resultsmentioning

confidence: 99%

The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis

Loopik

Bentley

Eijgenraam

et al. 2021

J Low Genit Tract Dis

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Section: Resultsmentioning

confidence: 99%

The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis

Loopik

Bentley

Eijgenraam

et al. 2021

J Low Genit Tract Dis

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“…Sasieni found progression rates of CIN in 1,5% of women treated for CIN II or CIN III at age 20-24 who would have developed cervical cancer ( 17 ). Some authors wrote that majority of LSIL lesions regress without medical intervention ( 18 ). Consequently, over–treatment at early stages should be avoided, especially in young women, and follow-up periods should be encouraged to make HPV clearence and histologic regression successful ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Difference Between Cryotherapy and Follow Up Low Grade Squamous Lesion of Cervix Uteri

et al. 2017

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Introduction:Cervical cancer can be successfully prevented by effective treatment.Aim:Analyse of success of cryotherapy in LSIL and ASCUS.Materials et methods:In retrospective study between January 2016 to March 2017, 3244 PAP test were analysed. 257 patients who had been diagnosed with LSIL and ASCUS from PAP smear were divided in two groups: women who had HPV positive, colposcopic positive and cytologic finding of LSIL or ASCUS treathed with cryotherapy and women with LSIL, ASCUS and negative colposcopy. χ2 test was used for statistical analysis of data.Results:Analysis of 3244 PAP smears showed negative for intraepithelial lesion or malignancy (NILM) in 90,10% (N-2923), and abnormal in 9,8% (N-321) of women. ASCUS was found in 4,8% (N-156) and ASC-H in 0,2% (N-6), LSIL in 3,1% (N-101), HSIL in 0,64% (N-21). The average age of patients with ASCUS lesion was 41 ± 12 years. After cryotherapy, HSIL had progression in 1,5% (N-1), persistence in 6,3% (N-4) and regression in 91,7% (N-58). Progression occured in 10,5% (N-4) of HSIL, persistence in 52,6% (N-20) and regression in 36,7% (N-14) in 38 women with LSIL lesion after repeated PAP test. Progression occured in 8% (N-10) of LSIL and 4% HSIL (N-5), persistence in 58% (N-72) and regression in 29,8% (N-37) in 124 women with ASCUS lesion after treatment and repeated PAP test. Difference in progression lesions in HSIL between women with cryotherapy (1,5%) and follow-up (10,5%) after LSIL is not significant, but progression to CIN II occured after cryotherapy. CIN III or cervical cancer was not found.Conclusion:Cryotherapy prevents progression of LSIL in HSIL and in cervical cancer. Because of that cryotherapy is successful method in prevention of cervical cancer.

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“…In researches HPV 16 and 18 were confirmed in over 70% of cervical cancers, 41% to 67% HSIL, 16% to 32% LSIL. HPV 16 and 18 are the most common types, followed by: HPV 31, 33, 45, 52 and 58 that are found in 20% of cervical carcinoma in the world ( 7 , 8 ).…”

Section: Discussionmentioning

confidence: 99%

Progression Low Squamous Intraepithelial Lesion and Human Papillomavirus Infections

Jahic¹,

Kamerić²,

Hadzimehmedovic³

2020

Mater Sociomed

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Introduction: Infection with human papillomavirus is the main cause of cervical carcinoma. In Bosnia and Herzegovina (BIH) 556 cases of cervical carcinoma are diagnosed annually, and 141 women die from it. Aim: To determine the most common HPV type found in ASCUS and LSIL and progression, regression and persistence of lesions. Methods: In a retrospective study, 11 051 PAP tests, performed in several private gynecological practices located in Tuzla Canton from January 2016 to December 2019, were analyzed. In processing of data , X 2 – statistical method was used. Results: 11051 PAP test were inspected. Normal findings were found in 90.48% (N-10002) and pathological findings in 9.49% (N- 049). ASCUS was present in 4.9% (N-544), LSIL in 3.04% (N-337), HSIL in 0.74% (N-84), ASC-H in 0.27% (N-30) and AGC in 0.49% (N-55) of cases. The most common is HPV 16, found in 50.5% (N-44) of ASCUS and LSIL. Monoinfection with HPV 16 was found in 40.9% (N-18) ASCUS (N-3) and LSIL (N-15), and a combination of HPV 16 with other types like HPV 18, 31, 33, 39 in 59% (N-26). Progression of ASCUS lesion in HSIL 1.6% (N-2), and LSIL 9.6% (N-12). Progression of LSIL to HSIL was found in 9.0% (N-10). HSIL progresses significantly more frequent from LSIL (p<0.05) than from ASCUS changes. Lesions that progress into higher grade HSIL are HPV 16 positive. Progression into HSIL is not found in patients with low-risk HPV 6 and 11 infection. Conclusion: Women infected with HPV 16 have more a frequent progression of a lesion into higher grade HSIL. They should be intensively monitored because of the increased risk for development of cervical carcinoma.

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Performance of Pap smear and human papilloma virus testing in the follow‐up of women with cervical intraepithelial neoplasia grade 1 managed conservatively

Abstract: Because cytological abnormalities correlated generally better with the persistence of biopsy-confirmed CIN1 in this follow-up protocol, HCII test is the second-hand option to Pap test, but the use of both Pap and HCII together seems an unnecessary waste of resources.

Cited by 10 publications

References 24 publications

The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis

The Natural History of Cervical Intraepithelial Neoplasia Grades 1, 2, and 3: A Systematic Review and Meta-analysis

Difference Between Cryotherapy and Follow Up Low Grade Squamous Lesion of Cervix Uteri

Progression Low Squamous Intraepithelial Lesion and Human Papillomavirus Infections

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