The hybrid time and wavelength division multiplexing passive optical network (TWDM-PON) with a 1:128 split ratio and 16- quadrature amplitude modulation orthogonal frequency division multiplexing (QAM-OFDM) modulation system using optical code division multiple access (OCDMA) code results in high transmission security, channel capacity and robustness against interference. Thus in this paper, a bidirectional symmetric 1.6 Tbps hybrid TWDM-OFDM PON system using two-dimensional spectral/spatial-single weight zero cross-correlation (2D-S/S SWZCC) code supporting a large number of users for long-reach as well as high-speed applications has been proposed and analysed considering fiber impairments and noise. Numerically calculated receiver sensitivity (RS) and splitter power budget (SPB) are -36dBm and 23dB for downstream as well as RS and SPB for upstream transmission of -33dBm and 10dB respectively showing the supremacy of using 2D-S/S SWZCC code in the system than other OCDMA codes. Also, the simulation results show that the proposed system using 2D-SS SWZCC code provides a faithful 120km transmission distance as well as a high transmission rate of 16×15/20Gbps with a maximum received power of -32.8dBm supporting more than 190 simultaneous users. The designed PON system offers the best performance over other conventional PONs. The number of users can be increased up to 250 with an optical signal-to-noise ratio of 110 dB and -30 dBm received power.