We consider a system with a source, relay and destination with arbitrary number of co-channel interferers and thermal noise at both the relay and the destination. The relay is equipped with multiple antennas, while the destination has a single antenna with limited interference-mitigation capabilities. For such a system, we propose a two-hop, Amplify-and-Forward relaying scheme, where the relay performs optimum combining (OC) to maximize the signal-to-interference-plus-noise ratio (SINR) and forwards the soft symbols to the destination. We derive the cumulative distribution function (CDF) of an upper bound on the end-to-end (e2e) SINR achievable with such a relay in Rayleigh-fading channels. The achievable diversity and outage probability performance are analyzed using the bound and simulations. Block-error-rate performance at the destination is studied and a practical application in cellular networks discussed. The results show that the proposed relay can assist a destination with a single antenna, which was experiencing lower SINR in the absence of the relay, to achieve higher values of SINR.Index Terms-Relays, half-duplex, optimum combining, interference mitigation, estimate-amplify-and-forward.