Performance of integrated FDG PET/contrast-enhanced CT in the diagnosis of recurrent colorectal cancer: Comparison with integrated FDG PET/non-contrast-enhanced CT and enhanced CT

Kitajima, Kazuhiro; Murakami, Koji; Yamasaki, Erena; Domeki, Yasushi; Tsubaki, Masahiro; Sunagawa, Masakatsu; Kaji, Yuichi; Suganuma, Narufumi; Sugimura, Kazuro

doi:10.1007/s00259-009-1081-5

Cited by 56 publications

(40 citation statements)

References 26 publications

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“…These data are further confirmed by Kitajima and colleagues in a series of studies in patients with uterine, ovarian, colorectal and pancreas cancer [8][9][10][11][12][13].…”

Section: Contrast-enhanced Studies With Pet/ct Hybrid Camerassupporting

confidence: 66%

Hybrid versus fusion imaging: are we moving forward judiciously?

Giovanella

Lucignani

2010

Eur J Nucl Med Mol Imaging

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“…These data are further confirmed by Kitajima and colleagues in a series of studies in patients with uterine, ovarian, colorectal and pancreas cancer [8][9][10][11][12][13].…”

Section: Contrast-enhanced Studies With Pet/ct Hybrid Camerassupporting

confidence: 66%

Hybrid versus fusion imaging: are we moving forward judiciously?

Giovanella

Lucignani

2010

Eur J Nucl Med Mol Imaging

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“…Although improved diagnostic performance of this application was reported in the clinical management of other malignancies [35], the clinical usefulness for breast cancer has not been established and further studies are necessary. In conclusion, FDG-PET/CT has poor sensitivity and high specificity in the detection of axillary lymph node metastasis of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of fluorodeoxyglucose-positron emission tomography/computed tomography of breast cancer in detecting axillary lymph node metastasis: comparison with ultrasonography and contrast-enhanced CT

et al. 2009

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“…The CT images from the PET/CT scans were not iodine contrast injected. The injection of the iodine product may have offered better identification, as demonstrated by Kitajima et al [25].…”

Section: Discussionmentioning

confidence: 97%

“…Previous series have included between 23 [12] and 107 [18] patients with 5 [12] to 40 [14] PC, but not all PC were of colorectal origin, possibly associated with various FDG uptake. The PET/CT method for CRC has been evaluated in larger series [19][20][21][22][23][24][25] but without a focus on PC. The prevalence of PC in our centre which is a regional reference centre for relapse cancer was 24% (35/146 patients).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of (18) F-FDG PET/CT for the detection of peritoneal carcinomatosis of colorectal origins

Bullier¹,

Descat²,

Bonichon³

et al. 2013

J Cancer Res Ther

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Purpose: to evaluate the diagnostic accuracy of (18)F-FDG positron emission tomography/ computerized tomography (PET/CT) for the detection of peritoneal carcinomatosis (PC) of colorectal cancer (CRC). Methods: one hundred and forty six eligible patients referred for a PET/CT to evaluate CRC at a single institution were included consecutively and retrospectively. After joint training on 20 similar patient files, two nuclear physicians reviewed the PET/CT scans blindly and independently using a method specifically designed for PC detection. The gold standard was either histological results from surgical exploration for resected patients (n=65) or clinical follow up defined as the 3-month CT follow up supplemented by one year of clinical information and CT monitoring for non-resected patients (n=81). As secondary objectives we evaluated the interobserver reliability between the two PET/CT readings and the diagnostic accuracy of a contemporary ceCT (n=69) or CT component of the PET/CT (n=77) reviewed by an independent radiologist . The extent of PC according to a simplified Sugarbaker index (PCI) was examined for the operated subgroup, when PCI was available from the surgeon and PET/CT (n=12). Results: according to the gold standard, 35/146 patients had PC (including 19 of 65 patients with histological gold standard and 16 of 81 patients with clinical follow up gold standard). Sensitivity and specificity of PET/ CT were 88% and 96% respectively and positive and negative predictive values and accuracy, 88%, 96% and 94% respectively. For CT alone, the corresponding values were: 68%, 92%, 72%, 90% and 86%. The interobserver agreement for the detection of peritoneal carcinomatosis in PET/CT showed high agreement at 0.91 (Kappa). Median PCI was 3 [range: 1-13] when assessed by surgeons and 4 [range: 1-10] on PET/CT. Focal uptake was the most frequently observed sign on PET. Conclusions: PET/CT appears to be an accurate and reproducible test for PC diagnosis in colorectal cancer using an interpretation method specifically designed for PC detection. To confirm these results and to evaluate peritoneal carcinomatosis extension accurately, a prospective observational study using iodine contrast-enhanced PET/CT as a first imaging technique for pre-operative staging and potentially involving further independent reviewers remains to be undertaken.

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Performance of integrated FDG PET/contrast-enhanced CT in the diagnosis of recurrent colorectal cancer: Comparison with integrated FDG PET/non-contrast-enhanced CT and enhanced CT

Abstract: Integrated PET/contrast-enhanced CT is an accurate modality for assessing colorectal cancer recurrence and led to changes in the subsequent appropriate therapy.

Cited by 56 publications

References 26 publications

Hybrid versus fusion imaging: are we moving forward judiciously?

Hybrid versus fusion imaging: are we moving forward judiciously?

Diagnostic performance of fluorodeoxyglucose-positron emission tomography/computed tomography of breast cancer in detecting axillary lymph node metastasis: comparison with ultrasonography and contrast-enhanced CT

Diagnostic accuracy of (18) F-FDG PET/CT for the detection of peritoneal carcinomatosis of colorectal origins

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