Performance of influenza case definitions for influenza community surveillance: based on the French influenza surveillance network GROG, 2009-2014

Casalegno, Jean-Sébastien; Eibach, Daniel; Valette, Martine; Enouf, Vincent; Daviaud, Isabelle; Behillil, Sylvie; Vabret, Astrid; Soulary, J.-C.; Benchaïb, Mehdi; Cohen, Jean Marie; Werf, Sylvie van der; Mosnier, Anne; Lina, Bruno

doi:10.2807/1560-7917.es.2017.22.14.30504

Cited by 67 publications

(103 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cough was the most frequently reported symptom, associated with IV, RSV and HMPV detections, as expected [1,3,17]. Presence of dyspnoea was associated with RSV infection and absence of dyspnoea was related to IV detection, as previously reported [16]. This is consistent with the biology of these viruses: typically, IV infections predominantly involve the upper respiratory tract and trachea [18,19], as human strains of IV primarily target cells of the upper airway [20], unlike RSV infections, which are more commonly associated with lower respiratory tract infections such as bronchiolitis and pneumonia [21,22].…”

Section: Discussionsupporting

confidence: 83%

“…The clinical signs associated with detection of a virus among patients with S-ILI varied among age groups. However, differences in age-related clinical symptoms should be interpreted cautiously, as the frequency of the four isolated viruses differed markedly among children and adults [4,16]. Consequently, the limited number of individuals for some age-subgroup analyses could explain in part the age-related differences in clinical signs highlighted.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Souty

Masse

Valette

et al. 2019

Clinical Microbiology and Infection

View full text Add to dashboard Cite

a b s t r a c tObjectives: We aimed to identify patients' clinical characteristics associated with respiratory viruses identified among patients presenting with influenza-like illness (ILI). Methods: A sample of patients of all ages presenting with ILI was included by physicians of the French Sentinelles network during two seasons (2015/16 and 2016/17). Nasopharyngeal samples were tested for the presence of influenza virus (IV), respiratory syncytial virus (RSV), human rhinovirus (HRV) and human metapneumovirus (HMPV). Patients' characteristics associated with each of the four virus classes were studied using multivariate logistic regressions. Results: A total of 5859 individuals were included in the study: 48.0% tested positive for IV, 7.9% for HRV, 7.5% for RSV and 4.1% for HMPV. Cough was associated with IV (OR 2.14, 95% CI 1.81e2.52) RSV (OR 2.52, 95% CI 1.75e3.74) and HMPV detection (OR 2.15, 95% CI 1.40e3.45). Rhinorrhoea was associated mainly with HRV detection (OR 1.75, 95% CI 1.34e2.32). Headache was associated with IV detection (OR 1.75, 95% CI 1.34e2.32), whereas absence of headache was associated with RSV and HMPV detection. Dyspnoea was associated with RSV detection (OR 2.33, 95% CI 1.73e3.12) and absence of dyspnoea with IV detection. Conjunctivitis was associated with IV detection (OR 1.27, 95% CI 1.08e1.50). Some associations were observed only in children: dyspnoea and cough with RSV detection (age <5 years), conjunctivitis with IV detection (age <15 years). Period of onset of symptoms differed among aetiological diagnoses. Seasonal influenza vaccination decreased the risk of IV detection (OR, 0.67, 95% CI 0.51e0.86).Conclusions: This study allowed the identification of symptoms associated with several viral aetiologies in patients with ILI. A proper knowledge and understanding of these clinical signs may improve the medical management of patients. C. Souty, Clin Microbiol Infect 2019;25:1147

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Souty

Masse

Valette

et al. 2019

Clinical Microbiology and Infection

View full text Add to dashboard Cite

show abstract

“…Although the SARI case definition showed a good association with influenza in this study, it is noteworthy that influenza was still identified in 3% of non‐SARI cases. It has been shown before that influenza case definitions are highly age‐dependant and performances vary due to the unspecific clinical picture of influenza . Hence, laboratory‐based surveillance systems using a SARI definition will probably underestimate the true burden of influenza infections.…”

Section: Discussionmentioning

confidence: 99%

Burden of influenza among hospitalized febrile children in Ghana

Hogan

Ammer

Zimmermann

et al. 2017

Influenza Resp Viruses

Self Cite

View full text Add to dashboard Cite

BackgroundInfluenza surveillance data from Africa indicate a substantial disease burden with high mortality. However, local influenza data from district hospitals with limited laboratory facilities are still scarce.ObjectivesTo identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.MethodsBetween January 2014 and April 2015, all children with a temperature of ≥38°C admitted to a district hospital in Ghana were screened for influenza A and B by RT‐PCR and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.ResultsA total of 1063 children with a median age of 2 years (IQR: 1‐4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (SARI) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09, and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3‐5 years and was more frequently detected in the major rainy season (OR = 2.9; 95% CI: 1.47‐6.19) during the first half of the year. Two (4%) and seven (15%) influenza‐positive children were co‐diagnosed with an invasive bloodstream infection or malaria, respectively.ConclusionInfluenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half‐year.

show abstract

“…As demonstrated in previous research, ILI represents a good proxy for influenza estimates [3, 24]. As no influenza virological confirmation was available, we took only into account ILI occurring during the influenza epidemic period identified by the Sentinelles network.…”

Section: Methodsmentioning

confidence: 99%

“…Clinical manifestations occur through influenza-like-illness (ILI) with sudden onset of fever, myalgia and respiratory signs [3]. …”

Section: Introductionmentioning

confidence: 99%

Factors associated with influenza-like-illness: a crowdsourced cohort study from 2012/13 to 2017/18

et al. 2019

View full text Add to dashboard Cite

Background Influenza generates a significant societal impact on morbidity, mortality, and associated costs. The study objective was to identify factors associated with influenza-like-illness (ILI) episodes during seasonal influenza epidemics among the general population. Methods A prospective study was conducted with the GrippeNet.fr crowdsourced cohort between 2012/13 and 2017/18. After having completed a yearly profile survey detailing socio-demographic, lifestyle and health characteristics, participants reported weekly data on symptoms. Factors associated with at least one ILI episode per influenza epidemic, using the European Centre for Disease Prevention and Control case definition, were analyzed through a conditional logistic regression model. Results From 2012/13 to 2017/18, 6992 individuals participated at least once, and 61% of them were women ( n = 4258). From 11% ( n = 469/4140 in 2013/14) to 29% ( n = 866/2943 in 2012/13) of individuals experienced at least one ILI during an influenza epidemic. Factors associated with higher risk for ILI were: gender female (OR = 1.29, 95%CI [1.20; 1.40]), young age (< 5 years old: 3.12 [2.05; 4.68]); from 5 to 14 years old: 1.53 [1.17; 2.00]), respiratory allergies (1.27 [1.18; 1.37]), receiving a treatment for chronic disease (1.20 [1.09; 1.32]), being overweight (1.18 [1.08; 1.29]) or obese (1.28 [1.14; 1.44]), using public transport (1.17 [1.07; 1.29]) and having contact with pets (1.18 [1.09; 1.27]). Older age (≥ 75 years old: 0.70 [0.56; 0.87]) and being vaccinated against influenza (0.91 [0.84; 0.99]) were found to be protective factors for ILI. Conclusions This ILI risk factors analysis confirms and further completes the list of factors observed through traditional surveillance systems. It indicates that crowdsourced cohorts are effective to study ILI determinants at the population level. These findings could be used to adapt influenza prevention messages at the population level to reduce the spread of the disease. Electronic supplementary material The online version of this article (10.1186/s12889-019-7174-6) contains supplementary material, which is available to authorized users.

show abstract

Performance of influenza case definitions for influenza community surveillance: based on the French influenza surveillance network GROG, 2009-2014

Cited by 67 publications

References 21 publications

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Burden of influenza among hospitalized febrile children in Ghana

Factors associated with influenza-like-illness: a crowdsourced cohort study from 2012/13 to 2017/18

Contact Info

Product

Resources

About