Performance of diagnostic biomarkers in predicting liver fibrosis among hepatitis C virus-infected Egyptian children

Nassef, Yasser; Shady, Mones M. Abu; Galal, Essam M.; Hamed, Manal A.

doi:10.1590/0074-0276130139

Cited by 13 publications

(11 citation statements)

References 42 publications

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“…PIIINP levels were higher among chronic HCV patients than in healthy controls in a small adult sample (p=0.0004) and a small pediatric sample (p=0.04) (37). A similar trend was found in another small pediatric HCV population (p<0.01) (48) and in a chronic HBV sample (p<0.05) (60). PIIINP levels correlated with fibrosis stage, and could reliably exclude inflammation and fibrosis in chronic HBV patients.…”

Section: Other Biomarkers Of Liver Fibrosissupporting

confidence: 62%

“…Elevated TIMP-1 predicts advanced fibrosis (F≥3) in HIV/HCV co-infected patients (p=0.001) (63). TIMP-1 levels were higher compared to controls in small adult (p<0.0001) and pediatric (p<0.003) chronic HCV samples (37), pediatric HCV (p<0.0001) (48), and in patients with active untreated IgG4-RD (p<0.01) (122). TIMP-1 levels were not different between chronic HCV patients and controls in a small sample (43).…”

Section: Other Biomarkers Of Liver Fibrosismentioning

confidence: 96%

“…Mean matrix metalloproteinase-2 (p=0.008) but not matrix metalloproteinase-9 (p=0.24) levels were significantly higher in chronic HBV patients with F4 fibrosis compared to F≤3 (54). Mean TGF-β1 levels were found to be elevated in HCV patients compared to controls (37,48). Treatment with everolimus lowered TGF-β levels compared to calcineurin inhibitors in a small sample of HCV patients who underwent liver transplantation (113).…”

Section: Other Biomarkers Of Liver Fibrosismentioning

confidence: 99%

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Hyaluronic acid as a non-invasive biomarker of liver fibrosis

Neuman

Cohen

Nanau

2016

Clinical Biochemistry

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Section: Other Biomarkers Of Liver Fibrosissupporting

confidence: 62%

Section: Other Biomarkers Of Liver Fibrosismentioning

confidence: 96%

Section: Other Biomarkers Of Liver Fibrosismentioning

confidence: 99%

See 1 more Smart Citation

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

Neuman

Cohen

Nanau

2016

Clinical Biochemistry

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“…Loss of hepatic GH-STAT5 signaling causes defects in lipid and glucose metabolism leading to steatosis, hyperglycemia, and insulin resistance. TGF-β 1 is secreted from HSC and Kupffer cells, but with inflammation hepatocytes gradually become the major source of TGF-β 1 [8][9][10][11]; it is the most important cytokine that stimulates the production of extracellular matrix (ECM) by HSC [12] and can induce apoptosis in hepatocytes, leading to cirrhosis [13].…”

Section: Introductionmentioning

confidence: 99%

The Role of Signal Transducer and Activator of Transcription 5 and Transforming Growth Factor-β<sub>1</sub> in Hepatic Fibrosis Induced by Chronic Hepatitis C Virus Infection in Egyptian Patients

2018

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Objective: To investigate the possible role of signal transducer and activator of transcription 5 (STAT5) in the pathogenesis of liver fibrosis in Egyptian patients with chronic hepatitis C (CHC) virus infection and its relation to hepatic stellate cells (HSC). Subjects and Methods: Sixty-five patients (46 males and 19 females) were divided into 4 groups based on the severity of fibrosis as detected by Fibroscan as follows: F1, n = 15; F2, n = 21; F3, n = 13; and F4, n = 16. Twenty age- and gender-matched healthy persons volunteered as controls. The serum levels of STAT5, TGF-β1, α-smooth muscle actin (α-SMA), fasting blood sugar, and fasting insulin, as well as homeostasis model assessment of insulin resistance (HOMA-IR), were determined and compared for all groups. The usefulness of the studied serum biomarkers for predicting liver fibrosis was evaluated using a receiver operating characteristic curve. Results: Serum levels of STAT5 were significantly lower in patients compared to controls (9.69 ± 5.62 vs. 14.73 ± 6.52, p ≤ 0.001); on the contrary, TGF-β1, α-SMA, and HOMA-IR were significantly higher in patients compared to controls (mean: 1,796.04 vs. 1,636.94; 14.94 vs. 8.1; and 7.91 vs. 4.18; p ≤ 0.01 and 0.001, respectively). TGF-β1 and α-SMA showed a progressive increase with advancing severity of hepatic fibrosis (mean TGF-β1: 2,058.4 in F1-F2 and 1,583.8 in F3-F4, p ≤ 0.04; mean α-SMA: 13.59 in F1-F2 and 16.62 in F3-F4, p ≤ 0.05). STAT5 had a significant negative correlation with TGF-β1 (p ≤ 0.001), while no correlation was detected with α-SMA (p ≤ 0.8). Conclusions: STAT5 may play a significant role in hepatic fibrogenesis through the induction of TGF-β1 but not through the activation of hepatic stellate cells.

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“…Aminotransferases are sensitive indicator of hepatocyte injury. The pattern of aminotransferase elevation, increasing AST/ALT ratio can be helpfull to diagnose in patients with chronic hepatitis [6], [7]. The ratio of serum AST/ALT was describe by De Ritis and known as De Ritis ratio.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Aspartate Aminotransferase/ Alanine Transferase Ratio (AST/ALT Ratio) and Stage of Liver Fibrosis in Patients with Chronic Hepatitis

Lumongga¹,

Anggraeni²

2017

Proceedings of the 1st Public Health International Conference (PHICo 2016)

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Abstract-Fibrosis is hallmark histologic event of chronic liver disease. Liver biopsy remains the gold standard for diagnosis and assessment of liver fibrosis in patients with chronic hepatitis. However, its invasive procedure and can have complication, not suitable for continous observation of liver fibrosis.The aspartate aminotransferase-alanin transferase ratio (AST/ALT ratio) has been used to evaluate prognosis of liver fibrosis and non-invasive proseduce for chronic hepatitis patients. To evaluate correlation betwen AST/ALT ratio and the stage of histologic liver fibrosis in chronic hepatitis patients.The study was restrospective design, where liver biopsy specimen has been collected from fourty chronic hepatitis patients during period Januari 2012 to December 2015. All histological slides were reviewed by two pathologists for evaluating histologic liver fibrosis by using Metavire score system. Patients characteristic were descriptifly analized, AST/ALT ratio and the stage of fibrosis were analized by using Spearman's correlation. The 40 patients were identified. The mean of age was 41 years, 70% patients were male. The number of patients with stage F1, F2, F3 and F4 of fibrosis respectively were 2 (5%), 16 (40%), 11 (27,5%), and 11(27,5%). The mean of AST/ALT ratio was 1,45 ± (SE mean 0,14) .We found that there was statistically significant positive correlation between AST/ALT ratio with the stage of fibrosis (r = 0,843 ; p value< 0,01). AST/ALT ratio was correlated with the stage of fibrosis. It is recomended to used the ratio as prediction of pogressive liver functional impairment.

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Performance of diagnostic biomarkers in predicting liver fibrosis among hepatitis C virus-infected Egyptian children

Cited by 13 publications

References 42 publications

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

The Role of Signal Transducer and Activator of Transcription 5 and Transforming Growth Factor-β<sub>1</sub> in Hepatic Fibrosis Induced by Chronic Hepatitis C Virus Infection in Egyptian Patients

Correlation Between Aspartate Aminotransferase/ Alanine Transferase Ratio (AST/ALT Ratio) and Stage of Liver Fibrosis in Patients with Chronic Hepatitis

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