Performance of cervical cytology and HPV testing for primary cervical cancer screening in Latin America: an analysis within the ESTAMPA study

Ramírez, Arianis Tatiana; Valls, Joan; Baena, Armando; Rojas, Freddy David; Ramírez, Katherine; Álvarez, Rodrigo; Cristaldo, Carmen; Henríquez, Odessa; Moreno, Adrián; Reynaga, Daysi Colque; Palma, Hans González; Robinson, Isabel; Hernández, Diana Carolina; Bardales, Rosa; Cardinal, Lucia; Salgado, Yuly; Martínez, Sandra; González, Emmanuel; Guillén, Diego; Fleider, Laura; Tatti, Silvio; Villagra, Verónica; Venegas, Gino; Cruz-Valdez, Aurelio; Valencia, Marleny; Rodríguez, Guillermo; Terán, Carolina; Picconi, María Alejandra; Ferrera, Annabelle; Kasamatsu, Elena; Mendoza, Laura; Calderon, Alejandro; Luciani, Silvana; Broutet, Nathalie; Darragh, Teresa; Almonte, Maribel; Herrero, Rolando; Rol, Mary Luz; Lucas, Eric; Hernández, María de la Luz; Sánchez, Gloria Inés; Murillo, Raul; Jerónimo, Jose; Ferreccio, Catterina; Rodríguez, María Isabel; Cabrera, Yessy; Salgado, Brenda; Colucci, María Celeste; Saino, Maria Agustina; Rodríguez de la Peña, Margarita; Fernández, Daniel Llanos; García, Laura; Caserta, Benedicta; Doimi, Franco; Lazcano-Ponce, Eduardo

doi:10.1016/j.lana.2023.100593

Cited by 9 publications

(3 citation statements)

References 27 publications

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“…The ESTAMPA subcohort found that HPV infection prevalence increased with cytology severity, indicating that the percentage of HPV-positive samples is higher in CC than CIN3, CIN2, and CIN1 [ 91 ]; they also found a phenomenon whereby HPV prevalence decreases with age, and HPV-positive samples are most commonly found in young women [ 91 , 92 ].…”

Section: Hpv and Cervical Cancer In Latin Americamentioning

confidence: 99%

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

Hernández-Silva,

Ramírez de Arellano,

Pereira-Suárez

et al. 2024

Viruses

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Cervical cancer is primarily caused by Human Papillomavirus (HPV) infection and remains a significant public health concern, particularly in Latin American regions. This comprehensive narrative review addresses the relationship between Human Papillomavirus (HPV) and cervical cancer, focusing on Latin American women. It explores molecular and immunological aspects of HPV infection, its role in cervical cancer development, and the epidemiology in this region, highlighting the prevalence and diversity of HPV genotypes. The impact of vaccination initiatives on cervical cancer rates in Latin America is critically evaluated. The advent of HPV vaccines has presented a significant tool in combating the burden of this malignancy, with notable successes observed in various countries, the latter due to their impact on immune responses. The review synthesizes current knowledge, emphasizes the importance of continued research and strategies for cervical cancer prevention, and underscores the need for ongoing efforts in this field.

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Section: Hpv and Cervical Cancer In Latin Americamentioning

confidence: 99%

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

Hernández-Silva,

Ramírez de Arellano,

Pereira-Suárez

et al. 2024

Viruses

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“…Cervical cancer screening strategies are currently mainly based on the HPV test as the primary screening test because of its greater sensitivity for cervical (pre)cancerous lesions compared with the Papanicolaou (Pap) test. 3 However, in the populations at increased risk for anal cancer, HPV prevalence is too high to use the HPV test as a primary screening tool. High-resolution anoscopy (HRA), with targeted biopsy, represents the gold standard for detecting and diagnosing anal precancerous lesions.…”

Section: Researchmentioning

confidence: 99%

Interobserver agreement in the interpretation of anal cytology

Benevolo,

Rollo,

Latini

et al. 2024

Cancer Cytopathology

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BackgroundAnal cytology represents a tool for anal cancer screening in high‐risk populations. In addition to accuracy, the reproducibility of the interpretation is of key importance. The authors evaluated the agreement of anal cytologic interpretation between two cytopathologists.MethodsLiquid‐based cytologic slides from human immunodeficiency virus (HIV)‐negative men who have sex with men (MSM) were evaluated by two readers with at least 10 years of expertise in cervical cytology. Cases with a discordant interpretation were reviewed, and a consensus was reached. Human papillomavirus (HPV) genotyping was performed using a proprietary HPV genotyping test. Unweighted and weighted Cohen kappa and 95% confidence interval (CI) values were calculated.ResultsOverall, 713 slides that were adequate for interpretation were evaluated (MSM: median age, 33 years). An HPV test was performed on 620 samples (87.0%). Considering a dichotomous interpretation (negative for intraepithelial lesion or malignancy vs. atypical squamous cells of undetermined significance or worse), the crude agreement between the two readers was 93.3% (kappa = 0.82; 95% CI, 0.77–0.87). Once a consensus for discordant cases was reached, the best agreement was found for the negative for intraepithelial lesion or malignancy category (511 of 528 samples; 96.8%), whereas the atypical squamous cells of undetermined significance category showed the lowest agreement (90 of 117 samples, 76.9%). Considering the individual cytologic categories, overall agreement was 92.1% (kappa = 0.85; 95% CI, 0.81–0.89). The discordant interpretations were not associated with high‐risk HPV infection, HPV16 infection, or MSM age.ConclusionsThe results indicating excellent interobserver agreement in this study substantiate the use of anal cytology in the setting of human immunodeficiency virus‐negative MSM.

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“…Cytology shows limited and highly variable sensitivity 13 that has been observed to decrease over time 14 . It requires equipment and expertise that differs from HPV testing, without being applicable for self-samples.…”

mentioning

confidence: 99%

Cervical cancer screening using DNA methylation triage in a real-world population

Schreiberhuber,

Barrett,

Wang

et al. 2024

Nat Med

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Cervical cancer (CC) screening in women comprises human papillomavirus (HPV) testing followed by cytology triage of positive cases. Drawbacks, including cytology’s low reproducibility and requirement for short screening intervals, raise the need for alternative triage methods. Here we used an innovative triage technique, the WID-qCIN test, to assess the DNA methylation of human genes DPP6, RALYL and GSX1 in a real-life cohort of 28,017 women aged ≥30 years who attended CC screening in Stockholm between January and March 2017. In the analysis of all 2,377 HPV-positive samples, a combination of WID-qCIN (with a predefined threshold) and HPV16 and/or HPV18 (HPV16/18) detected 93.4% of cervical intraepithelial neoplasia grade 3 and 100% of invasive CCs. The WID-qCIN/HPV16/18 combination predicted 69.4% of incident cervical intraepithelial neoplasia grade 2 or worse compared with 18.2% predicted by cytology. Cytology or WID-qCIN/HPV16/18 triage would require 4.1 and 2.4 colposcopy referrals to detect one cervical intraepithelial neoplasia grade 2 or worse, respectively, during the 6 year period. These findings support the use of WID-qCIN/HPV16/18 as an improved triage strategy for HPV-positive women.

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Performance of cervical cytology and HPV testing for primary cervical cancer screening in Latin America: an analysis within the ESTAMPA study

Cited by 9 publications

References 27 publications

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

Interobserver agreement in the interpretation of anal cytology

Cervical cancer screening using DNA methylation triage in a real-world population

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