Performance of an X-ray imaging detector based on a structured scintillator

Svenonius, Olof; Sahlholm, Anna; Wiklund, P. E.; Linnros, Jan

doi:10.1016/j.nima.2009.03.146

Cited by 37 publications

(15 citation statements)

References 8 publications

(8 reference statements)

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“…For the detectors, high resolution can only be achieved with low detection efficiency, which gives unnecessarily high dose and exposure time. Fortunately, new sources (Hemberg et al 2003) and detector concepts (Svenonius et al 2009) are being developed, which show promise for improved exposure time, detection efficiency and resolution. Figure 4 shows that the dose required to detect a 100 μm diameter vessel at SNR 2 = 25 can theoretically be reduced 300× compared to the present system.…”

Section: Discussionmentioning

confidence: 99%

X-ray phase contrast for CO₂microangiography

et al. 2012

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We demonstrate a laboratory method for imaging small blood vessels using x-ray propagation-based phase-contrast imaging and carbon dioxide (CO(2)) gas as a contrast agent. The limited radiation dose in combination with CO(2) being clinically acceptable makes the method promising for small-diameter vascular visualization. We investigate the possibilities and limitations of the method for small-animal angiography and compare it with conventional absorption-based x-ray angiography. Photon noise in absorption-contrast imaging prevents visualization of blood vessels narrower than 50 µm at the highest radiation doses compatible with living animals, whereas our simulations and experiments indicate the possibility of visualizing 20 µm vessels at radiation doses as low as 100 mGy. Experimental computed tomography of excised rat kidney shows blood vessels of diameters down to 60 µm with improved image quality compared to absorption-based methods. With our present prototype x-ray source, the acquisition time for a tomographic dataset is approximately 1 h, which is long compared to the 1-20 min common for absorption-contrast micro-CT systems. Further development of the liquid-metal-jet microfocus x-ray sources used here and high-resolution x-ray detectors shows promise to reduce exposure times and make this high-resolution method practical for imaging of living animals.

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Section: Discussionmentioning

confidence: 99%

X-ray phase contrast for CO₂microangiography

et al. 2012

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“…However, their light‐guiding properties are not optimal compared with an ideal needle‐shaped structure; the luminescent light is scattered because of insufficient separation between needles as well as their sidewall roughness. Svenonius et al have reported a higher spatial resolution for a pixelated scintillator,6 where the scintillator was divided into pixels the same size as the photodetector pixels. However, the pixelated scintillator and the photodetector pixels must be aligned.…”

Section: Composition and Properties Of The Pss Systemsmentioning

confidence: 99%

Development of Phase‐Separated Scintillators with Light‐Guiding Properties

et al. 2012

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“…In order to improve the modulation transfer function characteristics of the phosphor-based indirect detectors, structured scintillators, such as the columnar growth CsI, are generally used. 26,28,29 Hence, the optical scattering at the top surface of the columnar CsI growth, 30,31 the grain boundaries, and the disorder structure 32 can cause spatial sensitivity variations. Therefore, the acquired images are affected by the fixed pattern noise due to the nonuniform gains.…”

Section: Introductionmentioning

confidence: 99%