Performance of an inductively coupled plasma source ion trap mass spectrometer

Rapid Commun. Mass Spectrom.

Koppenaal

1997

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A plasma source ion trap (PSIT) mass spectrometer has been modified to incorporate a radiofrequency octopole ion guide/collision cell between the ion source and the mass spectrometer. This modification allows ions sampled from the plasma to undergo reactions prior to mass spectrometric analysis. This capability can obviate the need for chemical or chromatographic separation of the sample, remove mass spectral intereferences and enable formation of analytically useful molecular ions. Distinct reaction chemistries can be utilized in the octopole and/or ion trap. Performance of the instrument is dramatically improved if hydrogen gas is introduced into the octopole; molecular hydrogen reacts with Ar + and certain other plasma ions, greatly reduces their intensities, and cools and focuses the ion beam prior to its injection into the ion trap.

mentioning

confidence: 65%

“…The linear dynamic range of the PSIT is nearly 10 6 . Abundance sensitivity can be enhanced by resonant ejection to at least 10 5 .…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 93%

See 1 more Smart Citation

Beneficial Ion/Molecule Reactions in Elemental Mass Spectrometry

Eiden

Rapid Commun. Mass Spectrom.

Koppenaal

1997

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“…Isotopic analysis was performed using the atomic ions for each of the elements except for U. As is well known from early work in ICP-MS on Paul-type traps [25,26], atomic metal ions are quite reactive towards residual atmospheric gases (particularly O 2 ) in the trapping cell. The extent of oxide formation is a function of the metal ion's native oxygen affinity.…”

Section: Methodsmentioning

confidence: 99%

Preliminary Figures of Merit for Isotope Ratio Measurements: The Liquid Sampling-Atmospheric Pressure Glow Discharge Microplasma Ionization Source Coupled to an Orbitrap Mass Analyzer

Hoegg

J. Am. Soc. Mass Spectrom.

Hager

et al. 2016

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Abstract. In order to meet a growing need for fieldable mass spectrometer systems for precise elemental and isotopic analyses, the liquid sampling-atmospheric pressure glow discharge (LS-APGD) has a number of very promising characteristics. One key set of attributes that await validation deals with the performance characteristics relative to isotope ratio precision and accuracy. Owing to its availability and prior experience with this research team, the initial evaluation of isotope ratio (IR) performance was performed on a Thermo Scientific Exactive Orbitrap instrument. While the mass accuracy and resolution performance for Orbitrap analyzers are well-documented, no detailed evaluations of the IR performance have been published. Efforts described here involve two variables: the inherent IR precision and accuracy delivered by the LS-APGD microplasma and the inherent IR measurement qualities of Orbitrap analyzers. Important to the IR performance, the various operating parameters of the Orbitrap sampling interface, high-energy collisional dissociation (HCD) stage, and ion injection/data acquisition have been evaluated. The IR performance for a range of other elements, including natural, depleted, and enriched uranium isotopes was determined. In all cases, the precision and accuracy are degraded when measuring low abundance (<0.1% isotope fractions). In the best case, IR precision on the order of 0.1% RSD can be achieved, with values of 1%-3% RSD observed for low-abundance species. The results suggest that the LS-APGD is a promising candidate for field deployable MS analysis and that the high resolving powers of the Orbitrap may be complemented with a here-to-fore unknown capacity to deliver high-precision IRs.

“…Work in our laboratory has focused on use of the traditional inductively coupled plasma mass spectrometry (ICP/MS) approach with an ion trap mass spectrometer added or substituted for the conventional linear quadrupole mass filter [15,16]. Our first attempt in this endeavor was to build a combined plasma-linear quadrupole ion trap instrument.…”

Section: Introductionmentioning

confidence: 99%

Analytical atomic spectroscopy using ion trap devices

Analytical and Bioanalytical Chemistry

Eiden

Alexander

et al. 1996

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Investigations using ion trap devices for analytical atomic spectroscopy purposes have focused on the use of an inductively coupled plasma (ICP) ion source with ion trap mass spectrometric (ITMS) detection. Initial studies were conducted with an instrument assembled by simply appending an ion trap as the detector to a fairly conventional ICP/MS instrument, i.e. leaving an intermediate linear quadrupole between the plasma source and the ion trap. The principal advantages found with this system include the destruction of nearly all problematic and typical ICP/MS polyatomic ions (e.g., ArH(+), ArO(+), ArCl(+), Ar(2)(+), etc) and a dramatic reduction of the primary plasma source ion, Ar(+). These results prompted the development of a second-generation plasma source ion trap instrument in which direct coupling of the ICP and ion trap has been effected (i.e. no intermediate linear quadrupole); the same performance benefits have been largely preserved. Initial operation of this instrument is described, characterized, and compared to the originally described ICP/ITMS and conventional ICP/MS systems. In addition, experiments aimed at improving ICP/ITMS sensitivity and selectivity using broadband resonance excitation techniques are described. Finally, the potential for laser optical detection of trapped ions for analytical purposes is speculated upon.