Performance of an immunochromatography test for vivax malaria in the Amazon region, Brazil

Filho, Alberto Ferreira Figueiredo; Figueredo, Maria Cristina; Nascimento, José Maria; Calvosa, Vanja Suely Pachiano; Póvoa, Marinete Marins; Machado, Ricardo Luiz Dantas

doi:10.1590/s0034-89102003000300021

Rev. Saúde Pública

2003

DOI: 10.1590/s0034-89102003000300021

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Performance of an immunochromatography test for vivax malaria in the Amazon region, Brazil

Alberto Ferreira Figueiredo Filho

Maria Cristina Figueredo

José Maria Nascimento

et al.

Abstract: The study was carried out to evaluate the diagnostic performance of the ICT malaria Pf/Pv TM test for vivax malaria diagnosis in Belém, Amazon region, Brazil. The results of blood malaria parasites examination using an immunochromatography test were compared with thick blood film (TBF) examination. It was also evaluated the performance of this test storaged at three different temperatures (25°C, 30°C, and 37°C) for 24 hours before use. Overall sensitivity of ICT Pf/Pv TM was 61.8% with a specificity of 100%, p… Show more

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Cited by 9 publications

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“…The RDTs are known to produce false positive and negative results due to cross reaction with auto anti bodies. Though these tests are more simple and sensitive(Figueiredo Filhoa et al, 2003) than blood smear tests, they are more expensive and are best suited to assessing P vivax parasites and need improvements in performance. Polymerase Chain Reaction: Using the nonisotopically labeled probe following PCR amplification, it is possible to detect malaria parasites.…”

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confidence: 99%

Malaria Parasite Detection

Koppar

Sridhar²

2011

International Journal of E-Health and Medical Communications

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Healthcare Delivery Systems are becoming overloaded in developing countries like India and China. It is imperative that more efficient and cost effective processes are employed. One such requirement is the automatic detection of malaria parasites in stained blood smears. Malaria is a mosquito-borne infectious disease. Each year Malaria kills between one and three million people. The most conventional and gold standard test for the confirmation of the Malarial diagnosis is the peripheral blood smear examination. The paper investigates and develops an automated malaria diagnostic system based on the color image processing using Hue, Saturation & Intensity (HSI) model. The algorithm is designed to identify only parasites inside red blood cells (erythrocytes) to avoid false positive results. The work-flow process has enabled practical tele-pathology by allowing e-collaboration between lesser skilled technicians in rural areas and experts in urban areas, cutting down the total turnaround time for diagnosing malaria from days to minutes.

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confidence: 99%

Malaria Parasite Detection

Koppar

Sridhar²

2011

International Journal of E-Health and Medical Communications

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Rapid diagnostic tests for diagnosing uncomplicatedP. falciparummalaria in endemic countries

Abba

Deeks

Olliaro

et al. 2011

Cochrane Database of Systematic Reviews

187

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BackgroundRapid diagnostic tests (RDTs) for Plasmodium falciparum malaria use antibodies to detect either HRP-2 antigen or pLDH antigen, and can improve access to diagnostics in developing countries. ObjectivesTo assess the diagnostic accuracy of RDTs for detecting P. falciparum parasitaemia in persons living in endemic areas who present to ambulatory healthcare facilities with symptoms suggestive of malaria by type and brand.

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Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries

Abba

Kirkham

Olliaro

et al. 2014

Cochrane Database of Systematic Reviews

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BackgroundIn settings where both Plasmodium vivax and Plasmodium falciparum infection cause malaria, rapid diagnostic tests (RDTs) need to distinguish which species is causing the patients' symptoms, as different treatments are required. Older RDTs incorporated two test lines to distinguish malaria due to P. falciparum, from malaria due to any other Plasmodium species (non-falciparum). These RDTs can be classified according to which antibodies they use: Type 2 RDTs use HRP-2 (for P. falciparum) and aldolase (all species); Type 3 RDTs use HRP-2 (for P. falciparum) and pLDH (all species); Type 4 use pLDH (fromP. falciparum) and pLDH (all species).More recently, RDTs have been developed to distinguish P. vivax parasitaemia by utilizing a pLDH antibody specific to P. vivax.ObjectivesTo assess the diagnostic accuracy of RDTs for detecting non-falciparum or P. vivax parasitaemia in people living in malaria-endemic areas who present to ambulatory healthcare facilities with symptoms suggestive of malaria, and to identify which types and brands of commercial test best detect non-falciparum and P. vivax malaria.Search methodsWe undertook a comprehensive search of the following databases up to 31 December 2013: Cochrane Infectious Diseases Group Specialized Register; MEDLINE; EMBASE; MEDION; Science Citation Index; Web of Knowledge; African Index Medicus; LILACS; and IndMED.Selection criteriaStudies comparing RDTs with a reference standard (microscopy or polymerase chain reaction) in blood samples from a random or consecutive series of patients attending ambulatory health facilities with symptoms suggestive of malaria in non-falciparum endemic areas.Data collection and analysisFor each study, two review authors independently extracted a standard set of data using a tailored data extraction form. We grouped comparisons by type of RDT (defined by the combinations of antibodies used), and combined in meta-analysis where appropriate. Average sensitivities and specificities are presented alongside 95% confidence intervals (95% CI).Main resultsWe included 47 studies enrolling 22,862 participants. Patient characteristics, sampling methods and reference standard methods were poorly reported in most studies.RDTs detecting 'non-falciparum' parasitaemiaEleven studies evaluated Type 2 tests compared with microscopy, 25 evaluated Type 3 tests, and 11 evaluated Type 4 tests. In meta-analyses, average sensitivities and specificities were 78% (95% CI 73% to 82%) and 99% (95% CI 97% to 99%) for Type 2 tests, 78% (95% CI 69% to 84%) and 99% (95% CI 98% to 99%) for Type 3 tests, and 89% (95% CI 79% to 95%) and 98% (95% CI 97% to 99%) for Type 4 tests, respectively. Type 4 tests were more sensitive than both Type 2 (P = 0.01) and Type 3 tests (P = 0.03).Five studies compared Type 3 tests with PCR; in meta-analysis, the average sensitivity and specificity were 81% (95% CI 72% to 88%) and 99% (95% CI 97% to 99%) respectively.RDTs detecting P.vivax parasitaemiaEight studies compared pLDH tests to microscopy; the average sensitivity and specificit...

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Performance of an immunochromatography test for vivax malaria in the Amazon region, Brazil

Cited by 9 publications

References 4 publications

Malaria Parasite Detection

Malaria Parasite Detection

Rapid diagnostic tests for diagnosing uncomplicatedP. falciparummalaria in endemic countries

Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries

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