Sustainable synthetic carbon-based fuels can play a crucial role in the sectors of transportation, heating, and power, which can be challenging to electrify. Many of these synthetic fuels are based on green hydrogen produced by electrolysis. Due to difficulties in the handling and storage of hydrogen, an interesting solution is to convert it into hydrocarbons such as methane, with the advantage of using a well-established infrastructure and having the drop-in capability to substitute fossil natural gas. In the presented study, the partial load and the transient behavior of a sorption-enhanced catalytic reactor for methane synthesis is analyzed. This kind of reactor can achieve high conversion through adsorption of product water. Its performance is defined and compared to that of a simulated conventional fixed-bed catalytic reactor without sorption-enhancement. In particular, the focus is on investigating the response to partial loads and load transients. These operating conditions are typically met when the hydrogen production system is directly coupled with fluctuating renewable electricity production, and storage is minimized. The results show an excellent partial load behavior, and, unlike traditional reactors, sorption-enhanced catalysis did not show ignition problems. This article points out the strength of sorption-enhanced catalysis applied to the process of carbon dioxide methanation in transient and partial load operations both from the point of view of synthesized fuel quality and operation stability.