Performance of a coincidence based blood activity monitor

Moses, W.W.

doi:10.1109/23.106680

“…6c). We believe this is due to activation of 68 Ge in the BGO crystals from cosmic rays, since BGO crystals are contaminated by small amounts of 68 Ge [9].…”

Section: Resultsmentioning

confidence: 97%

Development of a High-Sensitivity Radiation Detector for Chromatography

Huber

¹

,

Hanrahan

²

,

Moses

³

et al. 2011

IEEE Trans. Nucl. Sci.

View full text Add to dashboard Cite

Radionuclide techniques will be increasingly important for the development of biofuels, since they can both uniquely characterize metabolic pathways and image large model systems. We are investigating the application of nuclear medical imaging tools and techniques to biofuel development, using highsensitivity chromatographic radiation detectors and compounds radiolabeled with short-lived, cyclotron-produced, positronemitting isotopes (e.g., 11 C). The application of high-sensitivity radiation detectors to standard chromatographic techniques should allow for the measurement of numerous pathway constituents whose levels normally fall below detection limits of conventional instrumentation. In this paper, we describe a proposed parallel-plane PET camera designed for HPLC (high performance liquid chromatography) with over 40 times greater sensitivity than a conventional HPLC radiation detector; this PET camera could be used to image radioactivity in the HPLC exit tube or column. We also present results using a highsensitivity HPLC radiation detector comprised of 8 HR+ PET detector modules arranged into a parallel plane and read out with HRRT electronics. This high-sensitivity radiation detector was placed in line after a conventional HPLC radiation detector (a small CsI:Tl scintillator crystal coupled to a PIN photodiode). If we inject 9.3 μCi of [ 18 F]FDG into the HPLC system, we see similarly shaped peaks with an excellent signal-to-noise ratio from both radiation detectors. If we inject only 4.1 nCi of [ 18 F]FDG, we measure a signal-to-noise ratio of 27:1 with the high-sensitivity radiation detector and about 3:1 for the conventional radiation detector. We have therefore demonstrated that a high-sensitivity radiation detector, using a parallel-plane PET camera, could become an important tool for fundamental biofuel research.

show abstract

“…6c). We believe this is due to activation of 68 Ge in the BGO crystals from cosmic rays, since BGO crystals are contaminated by small amounts of 68 Ge [9]. SNR 27:1 Figure 6.…”

Section: Resultsmentioning

confidence: 99%

Development of a high-sensitivity radiation detector for chromatography

Huber

¹

,

Hanrahan

²

,

Moses

³

et al. 2009

2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)

Self Cite

2

0

View full text Add to dashboard Cite

Radionuclide techniques will be increasingly important for the development of biofuels, since they can both uniquely characterize metabolic pathways and image large model systems. We are investigating the application of nuclear medical imaging tools and techniques to biofuel development, using highsensitivity chromatographic radiation detectors and compounds radiolabeled with short-lived, cyclotron-produced, positronemitting isotopes (e.g., 11 C). The application of high-sensitivity radiation detectors to standard chromatographic techniques should allow for the measurement of numerous pathway constituents whose levels normally fall below detection limits of conventional instrumentation. In this paper, we describe a proposed parallel-plane PET camera designed for HPLC (high performance liquid chromatography) with over 40 times greater sensitivity than a conventional HPLC radiation detector; this PET camera could be used to image radioactivity in the HPLC exit tube or column. We also present results using a highsensitivity HPLC radiation detector comprised of 8 HR+ PET detector modules arranged into a parallel plane and read out with HRRT electronics. This high-sensitivity radiation detector was placed in line after a conventional HPLC radiation detector (a small CsI:Tl scintillator crystal coupled to a PIN photodiode). If we inject 9.3 μCi of [ 18 F]FDG into the HPLC system, we see similarly shaped peaks with an excellent signal-to-noise ratio from both radiation detectors. If we inject only 4.1 nCi of [ 18 F]FDG, we measure a signal-to-noise ratio of 27:1 with the high-sensitivity radiation detector and about 3:1 for the conventional radiation detector. We have therefore demonstrated that a high-sensitivity radiation detector, using a parallel-plane PET camera, could become an important tool for fundamental biofuel research.

show abstract

“…In cases in which we report sensitivities and efficiencies, the values correspond to the low-count-rate limit of zero dead time. Moses (1990) describes a BGO coincidence system similar to that reported here. An important difference is that the system of Moses (1990) was constructed with cubic detectors with 5 cm sides.…”

Section: Discussionmentioning

confidence: 97%

“…Moses (1990) describes a BGO coincidence system similar to that reported here. An important difference is that the system of Moses (1990) was constructed with cubic detectors with 5 cm sides. Thus each detector contains ten times the volume of scintillator as the current system and consequently the reported coincidence efficiency of 37.5% is higher than the 19% of the Posi-RAM.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Evaluation of a commercial radiochromatography module as an arterial blood activity monitor

Laymon¹,

Sashin²,

Carney³

et al. 2007

Phys. Med. Biol.

2

0

View full text Add to dashboard Cite

Input functions required for positron emission tomography (PET) tracer kinetic modeling are often obtained from arterial blood. In some situations, using short-lived radiotracers, e.g. [(15)O]water, rapid sample handling is required. A method used at several facilities is to pump blood through a detector system at a constant rate. We investigate the suitability of a commercial radiochromatography module (IN/US Posi-RAM) for this new use. The Posi-RAM consists of two 2.5 cm (length) x 2.5 cm (diameter) cylindrical bismuth germanate (BGO) detectors that can operate in coincidence mode. Arterial blood is transported through the system via a length of tubing with flow rate controlled by a peristalsis pump. A custom-counting loop and support frame were designed for the Posi-RAM for PET studies. System sensitivity was determined to be 1.1 x 10(4) cps/(MBq ml(-1)). Dead time as a function of count-rate was found to be less than 1% for concentrations below 3.5 MBq ml(-1), a range encompassing all human-study values. In a human study, the performance of the device was found to be similar to that of the facility's current blood monitor (Siemens Fluid Monitor). We conclude that the Posi-RAM has the necessary sensitivity and count-rate capabilities to be used as a real-time blood activity monitor.

show abstract

Performance of a coincidence based blood activity monitor

Cited by 6 publications

References 8 publications

Development of a High-Sensitivity Radiation Detector for Chromatography

Development of a High-Sensitivity Radiation Detector for Chromatography

Development of a high-sensitivity radiation detector for chromatography

Evaluation of a commercial radiochromatography module as an arterial blood activity monitor

Contact Info

Product

Resources

About