Performance of 18F-FDG PET/contrast-enhanced CT in the staging of squamous cell carcinoma of the oral cavity and oropharynx

Krabbe, Christiaan A.; Balink, Hans; Roodenburg, Jan; Dol, Johan A.; Visscher, Jan G.A.M. de

doi:10.1016/j.ijom.2011.06.023

Cited by 46 publications

(32 citation statements)

References 40 publications

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“…Occult lymph nodes in the clinically negative neck (clinical N0 disease) represent a diagnostic challenge for PET/CT and MRI, as both techniques are not sensitive enough to reliably detect subcentimetre metastatic nodes. 15,26,30,31 In skilled hands, ultrasonography has been shown to be superior to CT and MRI because of its high spatial resolution and the ability to routinely perform power Doppler and ultrasonography FNAC. 3 The superiority of ultrasonography FNAC over CT and MRI is indisputable when dealing with small metastatic neck nodes, 32 and ultrasonography FNAC performs significantly better than any other imaging technique in the N0 neck.…”

Section: Current Evidence About Positron Emission Tomography/ct In Hnsccmentioning

confidence: 99%

Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI

Becker

Zaidi²

2014

BJR

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In head and neck oncology, the information provided by positron emission tomography (PET)/CT and MRI is often complementary because both the methods are based on different biophysical foundations. Therefore, combining diagnostic information from both modalities can provide additional diagnostic gain. Debates about integrated PET/MRI systems have become fashionable during the past few years, since the introduction and wide adoption of software-based multimodality image registration and fusion and the hardware implementation of integrated hybrid PET/MRI systems in pre-clinical and clinical settings. However, combining PET with MRI has proven to be technically and clinically more challenging than initially expected and, as such, research into the potential clinical role of PET/MRI in comparison with PET/CT, diffusion-weighted MRI (DW MRI) or the combination thereof is still ongoing. This review focuses on the clinical applications of PET/MRI in head and neck squamous cell carcinoma (HNSCC). We first discuss current evidence about the use of combined PET/CT and DW MRI, and, then, we explain the rationale and principles of PET/MR image fusion before summarizing the state-of-the-art knowledge regarding the diagnostic performance of PET/MRI in HNSCC. Feasibility and quantification issues, diagnostic pitfalls and challenges in clinical settings as well as ongoing research and potential future applications are also discussed.

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Section: Current Evidence About Positron Emission Tomography/ct In Hnsccmentioning

confidence: 99%

Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI

Becker

Zaidi²

2014

BJR

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“…When enhanced CT and PET are combined as a single study, the study provides more accurate anatomic details along with the biologic functional information about the primary tumor (36). Krabbe et al (37) conducted a retrospective study of whole-body 18 F-FDG PET/enhanced CT as a 1-step examination in the initial staging of unselected oral SCC and OPSCC. Seventy-three patients were included in the study, with 20 patients having OPSCC.…”

Section: Evaluation Of the Primary Sitementioning

confidence: 99%

PET/CT Imaging and Human Papilloma Virus–Positive Oropharyngeal Squamous Cell Cancer: Evolving Clinical Imaging Paradigm

et al. 2014

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“…(12) CT and MR remain the methods of choice for evaluation of the primary tumor in patients with head and neck cancer because of their better anatomic resolution. (13) However, it is often difficult to differentiate metastatic from nonmetastatic reactive nodes from CT and MR imaging, because the diagnosis of metastatic nodes is mainly based on measurement of nodal size. There have been many different size criteria for metastatic nodes with CT and MR imaging.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of CT Scan and MRI in The Assessment of Squamous Cell Carcinoma of The Oral Cavity and Its Cervical Lymph Node Metastasis

Koopaie

Karimi

2014

3dj

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Introduction: Squamous Cell Carcinoma (SCC) is the most common head and neck malignancy. To decrease the side effects of treatment and mortality from disease relapse, careful staging for the proper treatment plan is necessary. The main purpose of this prospective study is to compare the diagnostic value of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) in oral SCC and its lymph node metastasis in order to represent the proper treatment plan. Materials and Methods: 30 patients (19 men and 11 women) with oral SCC underwent CT and MRI before surgery. Imaging modalities of each study were evaluated individually for tumor size, bone invasion, muscle infiltration. These evaluations were done by two radiologists and an oral-maxillofacial surgeon and verified with histopathology findings as gold standard. The results of the radiological assessment were correlated with the intraoperative and histopathological findings in all patients. Results: CT and MRI have equal potential for detecting the tumor size, perineural invasion and nodal metastasis. The sensitivity and specificity were 50%, 90% for CT in the detection of bone invasion and 90%, 85% for MRI. The sensitivity and specificity were 66.66%, 90.47% for CT in detection of muscle infiltration and 55.55%, 90.47% for MRI. Conclusion:The comparison of these modalities showed no statistically significant difference between CT and MRI. Regarding bone infiltration the sensitivity of CT scan was higher than of MRI, but regarding muscle invasion the specificity of MRI was higher than of CT scan.

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Performance of 18F-FDG PET/contrast-enhanced CT in the staging of squamous cell carcinoma of the oral cavity and oropharynx

Cited by 46 publications

References 40 publications

Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI

Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI

PET/CT Imaging and Human Papilloma Virus–Positive Oropharyngeal Squamous Cell Cancer: Evolving Clinical Imaging Paradigm

A Comparative Study of CT Scan and MRI in The Assessment of Squamous Cell Carcinoma of The Oral Cavity and Its Cervical Lymph Node Metastasis

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