Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance

Weed, Michael R.; Taffe, Michael A.; Polis, Ilham; Roberts, Angela; Robbins, Trevor W.; Koob, George F.; Bloom, Floyd E.; Gold, Lisa

doi:10.1016/s0926-6410(99)00020-8

Cited by 153 publications

(158 citation statements)

References 61 publications

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“…DNMS choice accuracy was consistently less than perfect in the simultaneous condition, an observation that is consistent with all groups of animals trained in the lab on this task (e.g. Taffe et al (1999); Weed et al (1999)), as well as the delayed matching to sample variant (unpublished observations). Similarly, there was no significant effect of retention interval on choice accu- Mean performance of the MDMA-treated (N ϭ 3) and the vehicle-treated (N ϭ 3) groups on each of the behavioral tasks is summarized.…”

Section: Behaviorsupporting

confidence: 75%

“…A third test of the battery was designed to evaluate alterations of vigilance and reaction time (RT) and tests of fine motor coordination (Bimanual motor) and reinforcer efficacy (progressive ratio; PR) were included as well. Monkeys were trained to perform all tasks concurrently at a stable level of performance (see Weed et al (1999) for background) to provide a baseline against which to observe treatment effects. In addition to the behavioral tests, non-operant measures of brain function were also included.…”

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confidence: 99%

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Functional Consequences of Repeated (±)3,4-Methylenedioxymethamphetamine (MDMA) Treatment in Rhesus Monkeys

Taffe

Weed

Davis

et al. 2001

Neuropsychopharmacology

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Six rhesus monkeys were trained to stable performance on neuropsychological tests of memory, reinforcer efficacy, reaction time and bimanual motor coordination. Three monkeys were then exposed to a high-dose, short course regimen of ( Ϯ )3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") (4 days, 10 mg/kg i.m., b.i.d.) Recreational use of the psychoactive drug ( Ϯ )3,4,-methylenedioxymethamphetamine (MDMA) has become increasingly popular over the past two decades (Peroutka 1987;Schuster et al. 1998). Although early studies focused on adverse physiological (e.g., hypertension, hyperthermia, hyponatraemia) or psychiatric (mood disorder, aggression) symptoms associated with acute and/or chronic MDMA exposure, recent evidence suggests that chronic MDMA use may also result in lasting disruption of cognitive function. A number of studies have shown that experienced, abstinent MDMA users are impaired on various tests of memory function (Bolla et al. 1998;Curran and Travill 1997;Krystal et al. 1992;Morgan 1999;, even when compared with users of other recreational drugs. The lasting functional effects of MDMA use may be relatively specific to mnemonic processing, since a number of studies have reported that MDMA users who are impaired on memory tasks exhibit normal performance on tests of reaction time, vigilance or selective attention (Krystal et al. 1992;Vollenweider et al. 1998). Additional evidence suggests that the degree of memory impairment in the MDMA user is positively correlated with the number of cumulative exposures to MDMA (Bolla et al. 1998;Parrott and Lasky 1998). Finally, recent studies have demonstrated that electroencephalographic and metabolic (PET) measures of brain function are altered in MDMA users (Dafters et al. 1999;

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Section: Behaviorsupporting

confidence: 75%

mentioning

confidence: 99%

Functional Consequences of Repeated (±)3,4-Methylenedioxymethamphetamine (MDMA) Treatment in Rhesus Monkeys

Taffe

Weed

Davis

et al. 2001

Neuropsychopharmacology

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“…Monkeys were also tested on a PR task, a measure of the the monkeys' willingness to work for food rewards in the face of increasing response requirements. Test procedures were based on those used by Weed et al (1999), and the method was the same as that used by Baxter et al (2000). Testing was performed in an automated apparatus.…”

Section: Behavioral Testing Proceduresmentioning

confidence: 99%

Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency

Izquierdo¹,

Suda²,

Murray³

2004

J. Neurosci.

542

574

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The orbital prefrontal cortex (PFo) operates as part of a network involved in reward-based learning and goal-directed behavior. To test whether the PFo is necessary for guiding behavior based on the value of expected reward outcomes, we compared four rhesus monkeys with two-stage bilateral PFo removals and six unoperated controls for their responses to reinforcer devaluation, a task that assesses the monkeys' abilities to alter choices of objects when the value of the underlying food has changed. For comparison, the same monkeys were tested on a standard test of flexible stimulus-reward learning, namely object reversal learning. Relative to controls, monkeys with bilateral PFo removals showed a significant attenuation of reinforcer devaluation effects on each of two separate assessments, one performed shortly after surgery and the other ϳ19 months after surgery; the operated monkeys were also impaired on object reversal learning. The same monkeys, however, were unimpaired in acquisition of object discrimination learning problems and responded like controls when allowed to choose foods alone, either on a food preference test among six different foods or after selective satiation. Thus, satiety mechanisms and the ability to assign value to familiar foods appear to be intact in monkeys with PFo lesions. The pattern of results suggests that the PFo is critical for response selection based on predicted reward outcomes, regardless of whether the value of the outcome is predicted by affective signals (reinforcer devaluation) or by visual signals conveying reward contingency (object reversal learning).

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“…The monkeys were 5-7 years of age and weighed 5.0-8.5 kg. Monkeys were typically pair-housed and fed standard monkey chow (Harlan Teklad Global 20% protein Primate Diet 2050) in sufficient quantities to ensure normal growth while maintaining motivation to perform the tasks (Weed et al, 1999).…”

Section: Subjectsmentioning

confidence: 99%

Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains

Weed

Bookbinder

Polino

et al. 2015

Neuropsychopharmacol

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Antidepressant activity of N-methyl-D-aspartate (NMDA) receptor antagonists and negative allosteric modulators (NAMs) has led to increased investigation of their behavioral pharmacology. NMDA antagonists, such as ketamine, impair cognition in multiple species and in multiple cognitive domains. However, studies with NR2B subtype-selective NAMs have reported mixed results in rodents including increased impulsivity, no effect on cognition, impairment or even improvement of some cognitive tasks. To date, the effects of NR2B-selective NAMs on cognitive tests have not been reported in nonhuman primates. The current study evaluated two selective NR2B NAMs, CP101,606 and BMT-108908, along with the nonselective NMDA antagonists, ketamine and AZD6765, in the nonhuman primate Cambridge Neuropsychological Test Automated Battery (CANTAB) list-based delayed match to sample (list-DMS) task. Ketamine and the two NMDA NR2B NAMs produced selective impairments in memory in the list-DMS task. AZD6765 impaired performance in a nonspecific manner. In a separate cohort, CP101,606 impaired performance of the nonhuman primate CANTAB visuo-spatial Paired Associates Learning (vsPAL) task with a selective impairment at more difficult conditions. The results of these studies clearly show that systemic administration of a selective NR2B NAM can cause transient cognitive impairment in multiple cognitive domains.

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Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance

Cited by 153 publications

References 61 publications

Functional Consequences of Repeated (±)3,4-Methylenedioxymethamphetamine (MDMA) Treatment in Rhesus Monkeys

Functional Consequences of Repeated (±)3,4-Methylenedioxymethamphetamine (MDMA) Treatment in Rhesus Monkeys

Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency

Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains

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