Performance evaluation of the Trans-PET<sup>®</sup>BioCaliburn<sup>®</sup>LH system: a large FOV small-animal PET system

Wang, Luyao; Zhu, J.; Liang, Xiao; Niu, Muye; Wu, Xiaoke; Kao, Chien-Min; Kim, Heejong; Xie, Qingguo

doi:10.1088/0031-9155/60/1/137

Cited by 36 publications

(47 citation statements)

References 20 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After 60min of 18 F-FDG uptake, mice were anesthetized with isoflurane. Images were obtained after 10-15min scanning by a prototype-dedicated small-animal positron emission tomography (PET; Trans-PET BioCaliburn LH system) scanner developed at the Xie Laboratory, HUST 67 . More details can be found in the supplementary methods .…”

Section: Methodsmentioning

confidence: 99%

24-hour-restraint stress induces long-term depressive-like phenotypes in mice

Chu

Zhou

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subjected mice to 24-hour-restraint to simulate the trapping episode, and investigated the acute (2 days after the restraint) and long-term (35 days after the restraint) impacts. Surprisingly, we found that the mice displayed depression-like behaviors, decreased glucose uptake in brain and reduced adult hippocampal neurogenesis 35 days after the restraint. Differential expression profiling based on microarrays suggested that genes and pathways related to depression and other mental disorders were differentially expressed in both PFC and hippocampus. Furthermore, the depression-like phenotypes induced by 24-hour-restraint could be reversed by fluoxetine, a type of antidepressant drug. These findings demonstrated that a single severe stressful event could produce long-term depressive-like phenotypes. Moreover, the 24-hour-restraint stress mice could also be used for further studies on mood disorders.

show abstract

Section: Methodsmentioning

confidence: 99%

24-hour-restraint stress induces long-term depressive-like phenotypes in mice

Chu

Zhou

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…The scanner was calibrated using an 18 F planar source with a size of 120×90 mm, which collected data at three rotational positions with an angular interval of 60°. The total acquisition time was 90 min [25].…”

Section: Small-animal Pet Scanner Imagingmentioning

confidence: 99%

Imaging malignant melanoma with 18F-5-FPN

Feng

Xia

et al. 2015

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…A 14 × 14 tapered light-guide was designed to deliver the photons from 18 × 18 LYSO crystals into the PSPMT [9,10]. The top entrance size of the light-guide remains the same with the scintillator array crystal area (23.5 × 23.5 mm 2 ).…”

Section: Modular Construction Of the Pet Detectormentioning

confidence: 99%

Positron emission tomography detector performance with different crystal pitches

Tong

Fan

Dong

et al. 2017

Radiat Detect Technol Methods

View full text Add to dashboard Cite

Aims: In this work, we evaluated the performance of three pitches positron emission tomography (PET) detectors for building a high-resolution small-animal PET imaging experimental platform. Methods: The evaluation of PET detectors includes twodimensional crystal identification, energy resolution, and crystal look-up table. The nuclear instrumentation module and PXI data acquisition (DAQ) system were both used to obtain flood images. The energy spectrum of the Na-22 source was measured. PET detectors of 2.0 and 1.6 mm pitches used in our present experiment were composed of lutetium yttrium oxyorthosilicate (LYSO) crystals directly coupled to position-sensitive photomultiplier tubes (PSPMTs). The 1.3-mm pitch detector comprises a LYSO crystal, a tapered light-guide, and a PSPMT. The crystal sizes of the detectors were a 10 × 10 array of 2.0 × 2.0 × 10 mm 3 crystals, a 10 × 10 array of 1.6 × 1.6 × 10 mm 3 crystals, and an 18×18 array of 1.3×1.3×10 mm 3 crystals, respectively. Due to the lower sampling frequency of the DAQ system, a spline interpolation algorithm was introduced in the signal waveform to reconstruct the peak values. Results: The experimental results indicated that all three PET detector crystals could be clearly identified. A detailed analysis demonstrated that the key characteristic full width at half maximum (FWHM) values of the crystals profile could reach 0.46 ± 0.03, 0.32 ± 0.03, and 0.21 ± 0.02 mm, while the crystal average energy resolutions were 16.8% ± 1.76%, 20.1% ± 2.24%, and 31.5% ± 3.76%, which correspond to B YongZhi Yin yinyzh@lzu.edu.cn 1 School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China pitches of 2.0-, 1.6-, and 1.3-mm, respectively. Conclusions: The PET detector modules of LYSO crystal arrays could be potentially used in the small-animal PET imaging applications and are promising to achieve submillimeter PET images.

show abstract

Performance evaluation of the Trans-PET^®BioCaliburn^®LH system: a large FOV small-animal PET system

Abstract: the Trans-PET(®) BioCaliburn(®) LH system offers high spatial resolution, a large transaixal FOV and adequate sensitivity. It produces animal images of good quality and supports dynamic imaging. The system is an attractive imaging technology for preclinical research.

Cited by 36 publications

References 20 publications

24-hour-restraint stress induces long-term depressive-like phenotypes in mice

24-hour-restraint stress induces long-term depressive-like phenotypes in mice

Imaging malignant melanoma with 18F-5-FPN

Positron emission tomography detector performance with different crystal pitches

Contact Info

Product

Resources

About

Performance evaluation of the Trans-PET®BioCaliburn®LH system: a large FOV small-animal PET system

Abstract: the Trans-PET(®) BioCaliburn(®) LH system offers high spatial resolution, a large transaixal FOV and adequate sensitivity. It produces animal images of good quality and supports dynamic imaging. The system is an attractive imaging technology for preclinical research.

Cited by 36 publications

References 20 publications

24-hour-restraint stress induces long-term depressive-like phenotypes in mice

24-hour-restraint stress induces long-term depressive-like phenotypes in mice

Imaging malignant melanoma with 18F-5-FPN

Positron emission tomography detector performance with different crystal pitches

Contact Info

Product

Resources

About

Performance evaluation of the Trans-PET^®BioCaliburn^®LH system: a large FOV small-animal PET system