Performance evaluation of the new hematology analyzer Sysmex XN‐series

Abstract

The XN provided reliable results on low cell counts, as well as reduced manual blood film reviews, while maintaining a proper level of diagnostic sensitivity.

The value of the white precursor cell channel (WPC) on the Sysmex XN-1000 analyser in a specialist paediatric hospital

“…There was no appreciable increase in false positives for the atypical lymphocyte flag from WDF and overall efficiency of the flag was the same for both instruments. Our findings for this flag are remarkably consistent with those previously published,1 2 although both studies involved used the XE-2100 for comparison and had fewer true positives than this study.…”

“…Our evidence of greater specificity of the WPC blast flag concurs with results from other, mainly adult, studies 1 2…”

“…Automatic reflex analysis by WPC correctly removed the initial WDF ‘ Blasts/Abn lympho? ’ flag on 46% of samples, a reduction in false positives identical to results from an XN workflow study by Seo et al 2…”

“…With an instrument workload average of 300 samples per day in our department it can be assumed that the proportion of film reviews in laboratories with a much higher workload would be further reduced. This has been demonstrated in two previous large-scale studies which showed use of XN WPC reduced blood film reviews by approximately 50% compared to the Sysmex XE-2100 1 2…”

“…An initial evaluation of the XN haematology analyser was performed in 20121 and this has been followed by other publications 2 3. Briggs et al 1 showed that, on samples from adults, XN WPC produces fewer false positive abnormal WBC flags compared to the Sysmex XE-2100, without a loss of sensitivity.…”