Performance evaluation of the high sensitive troponin I assay on the Atellica IM analyser

Soto, Antonio Buño; Peoc’h, Katell; Fasano, Tommaso; Díaz-Garzón, Jorge; Presa, Bernardino González de la; Chicha-Cattoir, Valérie; Canovi, Simone; Pedro, Maria Sanz de; Rico, Nayra; Robert, Tiphaine; Bonelli, Efrem; Calle, Pilar Fernández; Mira, Áurea; Lefèvre, Guillaume; Vecchia, Luigi La; Bedini, José Luis

doi:10.11613/bm.2022.020709

Cited by 3 publications

(1 citation statement)

References 24 publications

(50 reference statements)

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“…Although supplementation with this water-soluble vitamin is highly unlikely to be associated with significant adverse effects, it is important to note that high-dose biotin supplementation can falsely alter the results of certain laboratory tests, namely troponin, thyroid hormone, or prolactin levels as well as at-home urine and pregnancy tests, especially when performed with traditional laboratory assays [2, 6]. Newer assays have shown less interference with biotin [7, 8].…”

Section: Nail Brittlenessmentioning

confidence: 99%

Natural Treatment Options for Nail Disorders

Baboun,

Yaghi,

Keri

et al. 2023

Skin Appendage Disord

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The growing demand for natural treatments has raised concerns among clinicians due to limited scientific evidence supporting their use. This review article addresses the issue by assisting dermatologists and general practitioners in recommending natural treatments for the following common nail disorders: nail brittleness, onychomycosis, periungual verrucae, paronychia, chloronychia, nail psoriasis, nail lichen planus, onychocryptosis, onycholysis, and congenital malalignment of the great toenail. One limitation is the scarcity of existing reviews on natural treatment options for nail disorders in the literature. Through a comprehensive review of existing literature, this article consolidates the available evidence on natural treatment options for these conditions. Although some natural treatments for nail disorders are supported by scientific evidence, the indiscriminate use of such remedies may lead to severe poisoning and health problems. Given the widespread and increasing use of natural treatments, clinicians play a pivotal role in educating patients about evidence-based remedies and debunking misleading claims. By doing so, clinicians can enhance patient safety and improve treatment outcomes. It is essential for healthcare professionals to be well-informed and equipped with the knowledge to differentiate between effective natural treatments and unverified claims, ensuring that patients receive appropriate care.

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Section: Nail Brittlenessmentioning

confidence: 99%

Natural Treatment Options for Nail Disorders

Baboun,

Yaghi,

Keri

et al. 2023

Skin Appendage Disord

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Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays

Xiong-Hang

Schulz

Sandoval

et al. 2023

Clinical Biochemistry

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Reference intervals for high sensitivity cardiac troponin I and N-terminal pro-B-type natriuretic peptide in children and adolescents on the Siemens Atellica

Ameh,

Brady

2024

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives The cardiac biomarkers high sensitivity cardiac troponin I (hs-cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are utilised in paediatric healthcare for the diagnosis and prognostic assessment of many conditions including myocarditis, congenital heart disease, multisystem inflammatory syndrome in children (MIS-C) and heart failure. However, the standardised age-related reference intervals, 99th percentile cut-offs and clinical guidelines are not available, making the interpretation of these biomarkers challenging. This study aimed to generate normative data in a paediatric cohort for the Siemens Atellica® IM 1300 analyser. Methods Residual plasma samples were collected from children aged up to 17 years attending primary care and out-patient settings and with no apparent evidence of cardiac dysfunction, renal dysfunction or other confounders. Reference intervals were generated using the 2.5th–97.5th percentiles, and 99th percentile cut-offs determined according to CLSI EP28-A3c. Results Statistical analysis revealed that partitioning was not required for gender for either biomarker. The reference interval for hs-cTnI for children aged one month to 16 years (n=292, 146 females and 146 males) was <14 ng/L with a 99th percentile cut-off of 19 ng/L. The reference interval for NT-proBNP for children aged one month up to one year was <714 ng/L (n=14) and for children aged 1–16 years (n=339) was <295 ng/L. Conclusions This is the first paediatric reference interval data generated on the Siemens Atellica® solution. These reference intervals and 99th percentiles will inform clinical decisions in the paediatric cardiology setting.

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Performance evaluation of the high sensitive troponin I assay on the Atellica IM analyser

Cited by 3 publications

References 24 publications

Natural Treatment Options for Nail Disorders

Natural Treatment Options for Nail Disorders

Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays

Reference intervals for high sensitivity cardiac troponin I and N-terminal pro-B-type natriuretic peptide in children and adolescents on the Siemens Atellica

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