Current Python programming environment does not have any reliable and efficient multiple precision floating-point (MPF) arithmetic except "mpmath" and "gmpy2" packages based on GNU MP(GMP) and MPFR libraries. Although it is well known that multi-componenttype MPF library can be utilized for middle length precision arithmetic under 200 bits, they are not widely used on Python environment. In this paper, we describe our accelerated MPF direct method with AVX2 techniques and its application to mixed precision iterative refinement combined with mpmath, and demonstrate their efficiency on x86 64 computational environments.