Performance Evaluation of Platelet Counting by Novel Fluorescent Dye Staining in the XN-Series Automated Hematology Analyzers

Abstract

The platelet counting performance of the PLT-F channel of the XN Series had improved accuracy and precision in the low range and in abnormal samples, avoiding the interference by nonplatelet particles.

Assessment of blood sample stability for complete blood count using the Sysmex XN-9000 and Mindray BC-6800 analyzers

“…Tanaka et al published data on the stability of the PLT count, 22 which are overall similar to the results observed in this study (PLT seem to be stable for up to 48 h in blood samples stored at both RT and at 4 °C). Discrepant data were instead found comparing our results with those obtained by Daves et al 23 and by Imeri et al 2 using the Sysmex XN-series.…”

Performance evaluation of the Sysmex®XP‐300 in an oncology setting: evaluation and comparison of hematological parameters with the Sysmex®XN‐3000

“…Tanaka et al . and Schoorl et al . demonstrated improved accuracy and imprecision of fluorescence platelets in the low range.…”

“…When fluorescence platelets (Plt-F) are available, as is the case in our laboratory, verification of a severe thrombocytopenia could aid in decision-making. Tanaka et al [10] and Schoorl et al [11] demonstrated improved accuracy and imprecision of fluorescence platelets in the low range. Briggs et al [12] reported a CV of 4%, Plt-F, for low platelet counts (<39 9 10 9 /L).…”

Clinical significance of IPF% measurement in diagnosing thrombocytopenic disorders: distinguishing primary immune thrombocytopenia from other disorders

“…Sakuragi et al [12] suggested in their study that IPF% was comparable to reticulated platelets measured by flow cytometry; it was considered as a supportive diagnostic test discriminating disorders such as ITP and aplastic anemia.…”

“…A high %-IPF indicates either consumptive or recovering thrombocytopenic disorders, such as immune thrombocytopenic purpura, while low %-IPF is characteristic of bone marrow suppression states [10,12].…”