Performance Evaluation of Maize Starch as a Multifunctional Excipient in Metronidazole Tablet Formulation

Apeji, Yonni Eshovo; Ali, Abdulhakim; Anyebe, Sophie Nock; Orugun, Oluwaseun Adenike; Olowosulu, Adeniji Kehinde; Oyi, Avosuahi Rukayat

doi:10.30827/ars.v60i3.9289

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the angle of repose for crystallo-co-agglomerates is 29.33°±0.96, Pure metronidazole has a significantly higher value of 41.93°±1.05, indicating that the pure crystals are cohesive and irregular in shape. Small angles of repose (≤ 30º) correspond to a faster flow rate of the material, an index of flowability of a powdered or granular substance [15]. A statistically significant difference was observed in the mean particle size (P value < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Improved flowability, mechanical and dissolution properties of metronidazole obtained from crystallo coagglomeration technique for direct tableting

Khalid ABDULLAHI,

OLOWOSULU,

ALLAGH

2024

jrp

View full text Add to dashboard Cite

There has recently been growing interest in exploring the potential of direct compression (DC) method of tableting as an alternative to the conventional granulation technique. This approach involves straightforward powder mixing and compression, resulting in time and cost savings, and has successfully been applied to various drugs. However, drugs require good micromeritic qualities, such as flowability, good reproducible compression behaviour to be directly compressed because it affects its in-vitro and in-vivo performance. Since many active pharmaceutical ingredients lack these qualities, the crystallo co-agglomeration technique hasemergedas a potential area of research for particle design,utilised in the development of active ingredients best suited for direct compression of tablet dosage forms. Pure metronidazole exhibited significantly higher Carr's index, Hausner's ratio, and angle of repose of 41.93°±1.05, indicating cohesiveness and irregular shape of the crystals.Whereas the crystallo-co-agglomerates were found to have an angle of repose of 29.33°±0.96, denoting an improvement in the flowability of the agglomerated crystals. Improvements in mechanical handling parameters was revealed in metronidazole co-agglomerate tablets produced with DC excipients (F1, F2). These tablets were found to be more robust and of higher quality compared to those formulated using pure metronidazole (F4, F5, F6), which were of no significant difference with metronidazole formulated via wet granulation method (F7, F8, F10, F11).In-vitro dissolution studies of metronidazole co-agglomerates tablets showed no significant difference in the percentage drug release profilebetween tablets produced via direct compression and wet granulation method. Thus, the crystallo co-agglomeration technique can be effectively used in the formulation of metronidazole tablets by direct compression using Avicel ® and Prosolv ® , presenting an efficient and streamlined approach to tablet manufacturing.

show abstract

Section: Discussionmentioning

confidence: 99%

Improved flowability, mechanical and dissolution properties of metronidazole obtained from crystallo coagglomeration technique for direct tableting

Khalid ABDULLAHI,

OLOWOSULU,

ALLAGH

2024

jrp

View full text Add to dashboard Cite

show abstract

Colocasia Esculenta Starch: Novel Alternative Disintegrant for Pharmaceutical Application

Kandekar¹,

Tapkir²,

Bhalerao³

et al. 2021

IND. DRU.

View full text Add to dashboard Cite

Oral drug delivery system has always been the most prevalent route of administration and continuous efforts are made to improve the drug delivery by this route. Tablets are one of the most extensively used dosage forms and various excipients have been developed for their formulation. The purpose of the current research work was to isolate and study the physicochemical properties of the Colocasia esculenta starch and further compare its disintegration ability with maize starch. Starch was isolated from C. esculenta corms by aqueous extraction method and possesses characteristics that are typical of starches. It was further evaluated for the presence of other foreign matter and phytoconstituents. Results showed that the isolated sample was free from foreign organic matter and the total ash value was found to be 0.4%. Tablets were prepared by the wet granulation method by varying concentrations in the range of 2.5 to 10% w/w for both the starches. Pre and post-compression parameters were studied and were found to be within the pharmacopoeial limits. Disintegration tests showed that disintegration time decreases with increasing concentration of both the starches. At 10% w/w concentration, disintegration time was found to be lowest, hence it was selected as an optimized formulation Stability studies were performed on F4 batch and it was found to be stable. The determination of disintegration efficiency indicates that C. esculenta starch exhibits disintegrating potential.

show abstract

Performance Evaluation of Maize Starch as a Multifunctional Excipient in Metronidazole Tablet Formulation

Cited by 2 publications

References 6 publications

Improved flowability, mechanical and dissolution properties of metronidazole obtained from crystallo coagglomeration technique for direct tableting

Improved flowability, mechanical and dissolution properties of metronidazole obtained from crystallo coagglomeration technique for direct tableting

Colocasia Esculenta Starch: Novel Alternative Disintegrant for Pharmaceutical Application

Contact Info

Product

Resources

About