Performance evaluation of A-SPECT: a high resolution desktop pinhole SPECT system for imaging small animals

McElroy, D.P.; MacDonald, L.R.; Beekman, Freek J.; Wang, Yuchuan; Patt, Bradley E.; Iwanczyk, Jan S.; Tsui, B.M.W.; Hoffman, Edward J.

doi:10.1109/tns.2002.803801

Cited by 135 publications

(72 citation statements)

References 21 publications

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“…The spatial transformation matrix for the registration is predetermined by a phantom scanning. A hardware approach would be the most useful and convenient method for small-animal imaging.In the past several years, a large number of small-animal SPECT [4][5][6][7][8], PET [9][10][11][12], and CT systems have been developed and become commercially available.Moreover, efforts to develop trimodality preclinical systems integrated in a common have not yet been reported.It is known that SPECT using a pinhole collimator has high spatial resolution, while PET has high sensitivity. This feature plays an important role when deciding whether to use SPECT or PET.…”

mentioning

confidence: 99%

Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging

Magota

Kubo

Kuge

et al. 2010

Eur J Nucl Med Mol Imaging

104

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3Purpose: We analyzed the performance of the Inveon for an integrated small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and the PET components.Methods: For SPECT, energy resolution, tomographic spatial resolution, and system sensitivity were evaluated with 99m Tc solution using a single pinhole collimator. For PET, spatial resolution, absolute sensitivity, scatter fraction, and peak noise equivalent count (NEC) were evaluated. A micro-Derenzo phantom, cylindrical phantom, and National Electrical Manufacturers Association NU-4 image quality phantom were scanned to compare SPECT and PET image capabilities, and SPECT and PET bone imaging were performed on a normal rat in vivo.Results: SPECT spatial resolution was 0.84 mm full width at half maximum (FWHM) at a radius of rotation of 25 mm using the 0.5-mm pinhole aperture collimator, while PET spatial resolution was 1.63 mm FWHM at the center. SPECT system sensitivity at a radius of rotation of 25 mm was 35.3 cps/MBq (4 × 10 -3 %) using 0.5-mm pinhole aperture, while PET absolute sensitivity was 3.2% for 350-650 keV and 3.432 ns. Accordingly, the volume sensitivity of PET was three orders of magnitude 4 higher than that of SPECT.Conclusions: This integrated PET/SPECT/CT system provided high system performance with excellent spatial resolution for SPECT and sensitivity for PET.Based on tracer availability and system performance, SPECT and PET have complementary roles for multi-modality small-animal imaging.Key Words: integrated PET/SPECT/CT system; small-animal imaging; performance measurement; instrumentation; molecular imaging 5 INTRODUCTIONMolecular imaging of small laboratory animals using single photon emission tomography (SPECT), positron emission tomography (PET), and x-ray computed tomography (CT) has recently emerged as an important tool for the in vivo study of animal models of human disease. This imaging method enables longitudinal studies to be performed in the same animal, and animals can serve as their own control.SPECT and PET have been used in functional imaging, including brain, heart, gene expression, and oncology studies [1,2]. CT has also been used for anatomical imaging (e.g., bone imaging) because it provides high contrast between bone and soft tissue [3]. The use of SPECT, PET, and CT in combinations such as SPECT/CT, PET/CT, SPECT/PET, and SPECT/PET/CT-so-called "multi-modality imaging"-may enable the development of new and interesting protocols for investigating many biological phenomena more effectively than is possible using SPECT, PET, or CT modalities alone. Using these techniques, lesions visualized by functional imaging can be correlated with anatomic imaging. In general, CT is also used for attenuation and scatter correction of SPECT and PET images. However, in this 6 study, neither attenuation nor scatter correction was performed.Integration of SPECT, PET, and CT images can be achieved by a "software approach" that fuses the images acquired by separate scanners. These techniques, however, are hamper...

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mentioning

confidence: 99%

Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging

Magota

Kubo

Kuge

et al. 2010

Eur J Nucl Med Mol Imaging

104

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“…Representative planar dual-modality images acquired on one of the systems mentioned above obtained from a 250-g rat injected with 99m Tc-MDP are shown in Figure 12, demonstrating radiopharmaceutical uptake in the bone superimposed with an anatomical x-ray image of the rat. 133,142 Gamma Medica 2 Inc. (Northridge, CA) has developed and introduced a small animal SPECT/CT system 137,138 with two compact scintillation cameras 126,143,144 and a high-resolution CT subsystem 138 for dual-modality Figure 11. Top: schematic diagram of the experimental set-up.…”

Section: Small-animal Imaging Systemsmentioning

confidence: 99%

Dual-Modality Imaging: More Than the Sum of its Components

Hasegawa

Zaidi

2006

Quantitative Analysis in Nuclear Medicine Imaging

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“…It has been well-proven in obtaining high spatial resolution, good performance and reliability in breast and small-animal imagers [6][7][8][9][10][11][12] . However, the high price of the discrete crystal array as compared to the continuous crystal usually leads to expensive cost for multi-camera SPECT system.…”

Section: Introductionmentioning

confidence: 99%

Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method

et al. 2010

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. (2010). Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method. Chinese Physics C, 34 (8), 1148-1152. Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method AbstractThe objective of this study is to investigate a high performance and lower cost compact gamma camera module for a multi-head small animal SPECT system. A compact camera module was developed using a thin Lutetium Oxyorthosilicate (LSO) scintillation crystal slice coupled to a Hamamatsu H8500 position sensitive photomultiplier tube (PSPMT). A two-stage charge division readout board based on a novel sub-tractive resistive readout with a truncated center-of-gravity (TCOG) positioning method was developed for the camera. The performance of the camera was evaluated using a flood 99mTc source with a four-quadrant barmask phantom. The preliminary experimental results show that the image shrinkage problem associated with the conventional resistive readout can be effectively overcome by the novel subtractive resistive readout with an appropriate fraction subtraction factor. The response output area (ROA) of the camera shown in the flood image was improved up to 34%, and an intrinsic spatial resolution better than 2 mm of detector was achieved.In conclusion, the utilization of a continuous scintillation crystal and a flat-panel PSPMT equipped with a novel subtractive resistive readout is a feasible approach for developing a high performance and lower cost compact gamma camera. Abstract The objective of this study is to investigate high performance and lower cost compact gamma camera module for multi-head small animal SPECT system. A compact camera module was developed using a thin Lutetium Oxyorthosilicate (LSO) scintillation crystal slice coupled to a Hamamatsu H8500 position sensitive photomultiplier tube (PSPMT). A two-stage charge division readout board based on novel subtractive resistive readout with truncated center-of-gravity (TCOG) positioning method was developed for the camera. The performance of the camera was evaluated using a flood 99mTc source with four-quadrant bar-mask phantom. The preliminary experimental results show that the image shrinkage problem associated with the conventional resistive readout can be effectively overcome by the novel subtractive resistive readout with an appropriate fraction subtraction factor, the response output area (ROA) of camera shown in the flood image was improved up to 34%, and an intrinsic spatial resolution better than 2mm of detector was achieved. In conclusion, the utilization of continuous scintillation crystal and flat-panel PSPMT equipped with the novel subtractive resistive readout is a feasible approach for development of high performance and lower cost compact gamma camera.

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Performance evaluation of A-SPECT: a high resolution desktop pinhole SPECT system for imaging small animals

Cited by 135 publications

References 21 publications

Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging

Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging

Dual-Modality Imaging: More Than the Sum of its Components

Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method

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