2006
DOI: 10.1373/clinchem.2005.057216
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Performance Evaluation and Subsequent Clinical Experience with the Abbott Automated Architect STAT Troponin-I Assay

Abstract: Background: Cardiac troponins are specific biochemical markers of myocardial injury used in the diagnosis of acute myocardial disease and cardiac risk stratification. To avoid misclassification of patients, troponin assays must demonstrate precision at the low end of the measuring range. We report our evaluation of the Architect STAT Troponin-I assay (Abbott Diagnostics), comparison of low-positive results with 2 other assays, and occurrence of heterophile antibody interference in the assay. Methods:We assesse… Show more

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Cited by 39 publications
(26 citation statements)
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“…Because 99th percentile values have been shown to vary by specimen type, it is important to clearly identify what specimen type was used in the methods section of a report (10,14,19,25 ). For example, Tate et al studied the 99th percentile in both plasma and serum among several cardiac troponin assays, finding concordant values for the 2 specimen types across the majority of assays.…”
Section: Serum Plasma or Whole Blood Cardiac Troponinmentioning
confidence: 99%
“…Because 99th percentile values have been shown to vary by specimen type, it is important to clearly identify what specimen type was used in the methods section of a report (10,14,19,25 ). For example, Tate et al studied the 99th percentile in both plasma and serum among several cardiac troponin assays, finding concordant values for the 2 specimen types across the majority of assays.…”
Section: Serum Plasma or Whole Blood Cardiac Troponinmentioning
confidence: 99%
“…4 However, only recently an assay (Roche troponin T hs assay) has become available that can consistently measure troponin T in about 50 -80% of the normal population. Furthermore, this assay provides increased precision at the 99th percentile.…”
mentioning
confidence: 99%
“…2 The first generation of troponin assays were already superior to the old creatine kinase MB assays 3 and the second-generation troponin assays improved diagnostic sensitivity compared with the first generation. 4 However, only recently an assay (Roche troponin T hs assay) has become available that can consistently measure troponin T in about 50 -80% of the normal population. Furthermore, this assay provides increased precision at the 99th percentile.…”
mentioning
confidence: 99%
“…At the time of the fourthgeneration assay use, the cutoff for cTnI was 0.03 g/L (30 ng/L) for both males and females. This roughly corresponded to our 99th percentile at the time of evaluation and introduction of the assay in 2004 (9 ). At the time of changeover to the high-sensitivity assay in July 2013 sexspecific 99th percentiles were adopted with cutoffs of 16 ng/L and 26 ng/L for females and males respectively.…”
Section: Methodsmentioning
confidence: 87%