Performance enhancing, immunomodulatory, anti-hyperlipidaemic, and antimicrobial properties of bael (Aegle marmelos) leaf powder in broiler chicken

Sharma, Dinesh K.; Mir, Nasir Akbar; Biswas, Avishek; Deo, Chandra

doi:10.1007/s11250-022-03054-5

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…This lower serum TC and TGs may suppress the fatty acid transport from the liver to adipose tissue, resulting in lower abdominal fat content as well as higher DY in the birds fed herbal rations [ 29 ], which is similar to the previous findings [ 20 , 22 ]. Birds served herbal rations showed a tendency toward higher liver percent due to lower dietary fat absorption [ 30 ], lipase activity [ 31 ], and/or hepatic lipogenesis [ 32 ] in broilers. Moreover, bioactive component-enriched herbs given to the bird revealed lower liver enzymatic activity, indicating less hepatic damage and a better percentage.…”

Section: Discussionmentioning

confidence: 99%

Combined impact of lemongrass and spearmint herbs on performance, serum metabolites, liver enzymes, and meat quality of broiler

Rahman¹,

Sultana²,

Redoy³

et al. 2022

J Adv Vet Anim Res

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Objectives: This study aimed to assess the influence of feeding fresh lemongrass (Cymbopogon citratus) or spearmint (Mentha spicata) and their combination on performance, serum metabo¬lites, liver enzymes, and meat quality in broilers. Materials and Methods: A total of 168 day-old Indian River chicks were arbitrarily offered four experimental rations: (i) control ration (CT-R): corn-soya-based ration, (ii) lemongrass ration (LG-R): CT-R + 1.0% DM of lemongrass; (iii) spearmint ration (SM-R): CT-R + 1.0% DM of spearmint; and (iv) lemongrass-spearmint ration (LS-R): CT-R + 0.5% DM from both lemongrass and spear¬mint. Each ration was given to 42 birds for a duration of 35 days, with 3 replications and 14 birds each. Results: Elevated body weight gain was observed in LG-R (1,502 gm), LS-R (1,492 gm), and SM-R (1,474 gm) compared to CT-R (1,451 gm) (p = 0.078). Herbal rations successfully reduced almost 3%–5% of serum and meat total cholesterol concentrations compared to CT-R. Compared to CT-R, the highest zinc and iron concentrations of serum and meat were measured in LG-R and SM-R, respectively, while both minerals of serum and meat were observed to be better in LS-R (p < 0.05). Herbal rations significantly improved serum liver enzyme activity and ameliorated the red color of breast and thigh meat but failed to improve the lightness and yellowness of both types of meat compared to CT-R. Conclusions: LG-R, SM-R, and LS-R improved bird performance, liver health, and meat color, and lowered serum and meat cholesterol levels. But among them, LS-R efficaciously increased the serum and meat zinc and iron concentrations.

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Section: Discussionmentioning

confidence: 99%

Combined impact of lemongrass and spearmint herbs on performance, serum metabolites, liver enzymes, and meat quality of broiler

Rahman¹,

Sultana²,

Redoy³

et al. 2022

J Adv Vet Anim Res

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GLP-1 Targeted Novel 3-phenyl-7-hydroxy Substituted Coumarins Mitigate STZ-induced Pancreatic Damage and Improve Glucose Homeostasis in OGTT Method

Gupta¹,

Srivastava²,

Kumar

et al. 2022

PPL

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Aim: To design, synthesize and evaluate the hypoglycemic activity of a new class of 7-hydroxy Coumarin derivatives. Background: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Recent studies support the search for coumarins or related compounds with potential blood glucose-lowering properties. Objective: To explore and establish the in-silico-driven pharmacological role of a new class of 7-hydroxy Coumarin derivatives as the therapeutic strategies against type 2 diabetes mellitus. Material and methods: A new class of 7-hydroxy Coumarin derivatives was designed by assessment of their physicochemical properties and molecular docking against the Glucagon-like peptide-1 (GLP-1) receptor. Two novel series of 30 compounds were synthesized. The chemical structures of all the synthesized analogues have been elucidated by spectral studies of IR, 1H-NMR, and mass spectroscopy. After considering the molecular docking score and their physicochemical properties, the compounds were screened out for the evaluation of their hypoglycemic potential. The compounds were investigated for their hypoglycemic activity using a streptozotocin (STZ) induced diabetic model and an oral glucose tolerance test (OGTT) method at different dose levels. Result: The molecular docking studies of synthesized derivatives reveal significant molecular interaction with the various amino acid residues of GLP-1 receptor. IR spectral analysis revealed a strong band of -NH stretching in the range of 3406.7-3201.61 cm-1 and one strong band for the lactone carbonyl group of the coumarin ring in the range of 1722.0-1703.5 cm-1, confirming the chemical structure of all produced compounds. The synthesized coumarin analogues with the best docking score exhibited remarkable hypoglycemic potential as assessed by STZ model and the OGTT method. Conclusion: good structure-activity relationship (SAR) and produced significant hypoglycemic potential.

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Performance enhancing, immunomodulatory, anti-hyperlipidaemic, and antimicrobial properties of bael (Aegle marmelos) leaf powder in broiler chicken

Cited by 2 publications

References 30 publications

Combined impact of lemongrass and spearmint herbs on performance, serum metabolites, liver enzymes, and meat quality of broiler

Combined impact of lemongrass and spearmint herbs on performance, serum metabolites, liver enzymes, and meat quality of broiler

GLP-1 Targeted Novel 3-phenyl-7-hydroxy Substituted Coumarins Mitigate STZ-induced Pancreatic Damage and Improve Glucose Homeostasis in OGTT Method

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