Performance Comparison of two Novel Combinative Particle-Size-Reduction Technologies

Glibenclamide Nanocrystals in a Biodegradable Chitosan Patch for Transdermal Delivery: Engineering, Formulation, and Evaluation

“…In addition, the fast precipitation process induces particle friability, drug crystal defects, and dendritic morphology facilitating the particle size reduction of the homogenization stage. 24,25 Assessment of Drug Crystallinity DSC thermogram of the unprocessed micronized GBD displayed a sharp endothermic melting peak at 177 C (Fig. 2), whereas DSC thermograms of the precipitated and homogenized GBD showed minor changes in the melting peak of GBD (171 C and 174 C for the precipitated and homogenized GBD, respectively).…”

Preparation, characterizations and anti-pollutant activity of 7,3′,4′-trihydroxyisoflavone nanoparticles in particulate matter-induced HaCaT keratinocytes

“…Salazar et al indicated that reduction of particle size into the nanometer range can increase the surface area of drugs to improve their aqueous solubility and bioavailability. 29 Our results demonstrated that 734THI co-grinded with PVP K30 can reduce the particle size about 12-fold, and increase the aqueous solubility about 39-fold, when compared to raw 73THI. These results indicated that 734THI complexed with PVP K30 after planetary ball mill preparation has smaller particle size and more uniform particle size distribution, when compared to raw 734THI.…”

Production of pure drug nanocrystals and nano co-crystals by confinement methods

“…The combination of different particle size reduction technologies can also be employed to improve the particles size reduction, combining the effectiveness of the standard top-down and bottom-up techniques [52,53]. Generally, the first step consists of a precipitation approach (e.g., free-drying or spray drying) that modifies the drug structure to obtain a brittle and friable starting material for the subsequent homogenization process [52,53]. The main combination technologies that have been used are discussed in detail in section 3.…”