Performance Comparison of Commercial and Home-Made Lipases for Synthesis of Poly(δ-valerolactone) Homopolymers

Abstract

Novozyme 435, which is the commercially available immobilized form of Candida antarctica lipase B, has been successfully conducted ring opening polymerization of lactones in organic solvents. In this paper, it was aimed to introduce an alternative biocatalyst for Novozyme 435. Candida antarctica lipase B immobilized onto rice husk ashes via physical adsorption (with a specific activity of 4.4 U/mg) was prepared in previous studies and used as a biocatalyst for poly(δ-valerolactone) synthesis in the present work. Polymerization reactions were proceeded at various reaction temperatures and periods via both two immobilized enzyme preparations. The resulting products were characterized spectroscopically and thermally. The highest molecular weight (Mn = 9010 g/mol) was obtained via Novozyme 435 catalysis at 40℃ and 24 hours. The performance of home-made lipase, which resulted in a molecular weight of 8040 g/mol, was close to commercial one.

Bis(dibenzoylmethanato)Zirconium(IV) Chloride Complex as a Potential Catalyst for the Ring Opening Polymerization of d-Valerolactone

“…Finally, the signal that appears at 3.6 ppm is the methylene proton at the end of the PVL chain (Ha'). The results of the 1 HNMR PVL analysis obtained are alike to those obtained by previous researchers [10] [20].…”

“…The resulting PVL melting point curve is also relatively sharp. Both the Tm value and the Tm curve obtained are alike to be the results obtained by previous researchers [20], [24]. On the other hand, the low value (Tm) of PVL is caused by its natural characteristics, such as structure, bonding, and molecular weight.…”

Poly(trimethylene carbonate-co-valerolactone) copolymers are materials with tailorable properties: from soft to thermoplastic elastomers

“…61 Overall, it was demonstrated that when utilizing TBD-based catalytic systems, it is possible to obtain P(TMC-co-VL) copolymers with dramatically different mechanical properties via onepot procedure by simply adjusting the comonomer ratio in the reaction feed. Considering their biocompatibility 51,67,68 and biodegradability, [69][70][71] these materials could be highly suitable for so tissue engineering, where the material's mechanical properties should match those of the tissue as much as possible, 72 or drug delivery. The C1 and PC1 copolymers exhibited properties comparable to previously reported biodegradable thermoplastic elastomers.…”