Performance comparison of a current LSO PET scanner versus the same scanner with upgraded electronics

Puterbaugh, Kenneth; Breeding, J. Ernest; Musrock, M.S.; Seaver, C.; Casey, Michael; Young, John W.

doi:10.1109/nssmic.2003.1352257

Cited by 10 publications

(8 citation statements)

References 4 publications

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“…This is triple the radioactivity recommended by NEMA (14) for a"standardized imaging situation thats imulatesac linical imaging situation". Howeverthese radioactivity concentrationsm ay be found in PET-measurements with short-livedr adiotracers( 11 C, 13 N, 15. O).…”

Section: Discussionmentioning

confidence: 99%

“…Cameras equipped with LSOcrystals are superior to those using BGOathigher radioactivity concentrations. This mayb ei mportant when acquiring dynamicstudies during bolus injection or when using higherd oses (6), e.g.toshortenthe acquisition time with the aim of less movement artifacts,a nd/or higherp atientt hroughput.Whereas,t he application of more 18 F-labelled radiotracer maybelimited by radiation protection issues, this problemislessrelevant for studieswith the fast decaying positron emitters 11 C, 13 N, or 15 O, which gain fromthe useoffastdetectors with improved count rate performance.…”

Section: Impact Of Energy Threshold On Lsopetmentioning

confidence: 99%

See 1 more Smart Citation

Impact of the lower energy threshold on the NEMA NU2-2001 count-rate performance of a LSO based PET-CT scanner

Eckardt

Herzog²,

Schäfers³

et al. 2008

Nuklearmedizin

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Section: Discussionmentioning

confidence: 99%

Section: Impact Of Energy Threshold On Lsopetmentioning

confidence: 99%

Impact of the lower energy threshold on the NEMA NU2-2001 count-rate performance of a LSO based PET-CT scanner

Eckardt

Herzog²,

Schäfers³

et al. 2008

Nuklearmedizin

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“…In the conventional (non-TOF) SSS algorithm, the expected single-scatter coincidence rate in the detector pair due to scatter in the object, is estimated as the volume integral of a scattering kernel over the scattering medium according to [6]: (1) where, Referring to Fig. 1, is the total scatter volume (that is, the entire volume of finite density), S is the scatter point, is an incremental volume element at S, s is the distance from the scatter point along a ray such as AS, is the geometrical cross section of detector A for -rays incident along AS, is the distance from S to A, is the efficiency of detector A for -rays incident along AS, is the linear attenuation coefficient, is the emitter density in the object, is the total Compton interaction cross section, and is the scattering solid angle.…”

Section: Methodsmentioning

confidence: 99%

“…T HE introduction of fast, efficient, scintillator detectors and improved digital front-end electronics has spurred recent developments aimed at providing differential time-of-flight (TOF) measurement capabilities for clinical positron emission tomography (PET) [1]- [5]. TOF measurements discriminate the differential arrival time of the two nominally coincident annihilation photons.…”

Section: Introductionmentioning

confidence: 99%

Extension of Single Scatter Simulation to Scatter Correction of Time-of-Flight PET

Watson¹

2007

IEEE Trans. Nucl. Sci.

124

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We extend the single scatter simulation (SSS) algorithm for scatter correction of three dimensional positron emission tomography to include the case in which the scattered annihilation radiation is discriminated according to its differential time-offlight (TOF). Good agreement between computed and measured TOF dependent scatter is observed in phantom and human data. Significant differences between TOF dependent and non-TOF dependent scatter are found. Because TOF scoring removes the degeneracy in ray sum calculations, TOF SSS takes about seven times longer than non-TOF SSS to compute the scatter sinogram itself. However, when the overhead due to image computation and iteration is factored in, the clinical performance is only a factor of three slower.

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“…High-speed electronics offer precise data acquisition with considerably reduced random events. Consequently, the accuracy and signal-to-noise ratio are greatly improved [14], allowing theoretical model-based scatter compensation [15–20] to be accurately applied. A markedly improved performance in 3D PET is essential for better image quality and increased accuracy, while simultaneously reducing the radiation dose in patients [21].…”

Section: Introductionmentioning

confidence: 99%

System evaluation of automated production and inhalation of 15O-labeled gaseous radiopharmaceuticals for the rapid 15O-oxygen PET examinations

et al. 2018

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Background15O-oxygen inhalation PET is unique in its ability to provide fundamental information regarding cerebral hemodynamics and energy metabolism in man. However, the use of 15O-oxygen has been limited in a clinical environment largely attributed to logistical complexity, in relation to a long study period, and the need to produce and inhale three sets of radiopharmaceuticals. Despite the recent works that enabled shortening of the PET examination period, radiopharmaceutical production has still been a limiting factor. This study was aimed to evaluate a recently developed radiosynthesis/inhalation system that automatically supplies a series of 15O-labeled gaseous radiopharmaceuticals of C15O, 15O2, and C15O2 at short intervals.MethodsThe system consists of a radiosynthesizer which produces C15O, 15O2, and C15O2; an inhalation controller; and an inhalation/scavenging unit. All three parts are controlled by a common sequencer, enabling automated production and inhalation at intervals less than 4.5 min. The gas inhalation/scavenging unit controls to sequentially supply of qualified radiopharmaceuticals at given radioactivity for given periods at given intervals. The unit also scavenges effectively the non-inhaled radioactive gases. Performance and reproducibility are evaluated.ResultsUsing an 15O-dedicated cyclotron with deuteron of 3.5 MeV at 40 μA, C15O, 15O2, and C15O2 were sequentially produced at a constant rate of 1400, 2400, and 2000 MBq/min, respectively. Each of radiopharmaceuticals were stably inhaled at < 4.5 min intervals with negligible contamination from the previous supply. The two-hole two-layered face mask with scavenging device minimized the gaseous radioactivity surrounding subject’s face, while maintaining the normocapnia during examination periods. Quantitative assessment of net administration doses could be assessed using a pair of radio-detectors at inlet and scavenging tubes, as 541 ± 149, 320 ± 103, 523 ± 137 MBq corresponding to 2-min supply of 2574 ± 255 MBq for C15O, and 1-min supply of 2220 ± 766 and 1763 ± 174 for 15O2 and C15O2, respectively.ConclusionsThe present system allowed for automated production and inhalation of series of 15O-labeled radiopharmaceuticals as required in the rapid 15O-Oxygen PET protocol. The production and inhalation were reproducible and improved logistical complexity, and thus the use of 15O-oxygen might have become practically applicable in clinical environments.

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Performance comparison of a current LSO PET scanner versus the same scanner with upgraded electronics

Cited by 10 publications

References 4 publications

Impact of the lower energy threshold on the NEMA NU2-2001 count-rate performance of a LSO based PET-CT scanner

Impact of the lower energy threshold on the NEMA NU2-2001 count-rate performance of a LSO based PET-CT scanner

Extension of Single Scatter Simulation to Scatter Correction of Time-of-Flight PET

System evaluation of automated production and inhalation of 15O-labeled gaseous radiopharmaceuticals for the rapid 15O-oxygen PET examinations

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