Performance Assessment of the SOFA, APACHE II Scoring System, and SAPS II in Intensive Care Unit Organophosphate Poisoned Patients

Kim, Yong Hwan; Yeo, Jung Hoon; Kang, Mun Ju; Lee, Jun Ho; Cho, Kwang Won; Hwang, Seong Youn; Hong, Chong Kun; Lee, Young Hwan; Kim, Yang Weon

doi:10.3346/jkms.2013.28.12.1822

Cited by 44 publications

(64 citation statements)

References 19 publications

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“…30 An explanation for the observed difference may stem from the more complex nature of septic shock as compared with poisoning both in onset and evolution. Moreover, the simplicity of the SOFA score, in particular the absence of parameters related to associated diseases makes it more relevant to organ dysfunctions, unlike SAPS II and APACHE II that evaluate multiple organ dysfunction specific to the critically septic patient.…”

Section: Discussionmentioning

confidence: 99%

Assessment and comparison of 3 mortality prediction models SAPS II, APACHE II and SOFA for prediction of mortality in patients of sepsis

et al. 2017

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Background: Little is known about outcomes of patients admitted to the ICU with severe sepsis and septic shock, despite the seriousness of sepsis as a public health problem in developing countries. Understanding sepsis outcome studies is hampered by lack of an agreed severity of illness scoring system for sepsis patients. The objective of the present study is to assess and compare the validity of 3 mortality prediction models SAPS 2, APACHE II and SOFA for prediction of mortality in patients of sepsis.Methods: One hundred patients of Sepsis were selected after applying the inclusion and exclusion criteria. Informed consent was taken from the patients or their relatives A careful and detailed history was recorded to assess the onset and duration of clinical events and the probable risk factors for the same; a detailed general physical examination was performed. Blood sampling for CBC, RFT, LFT and arterial blood gas analysis was done. SAPS 2, APACHE II and SOFA scores were calculated on the day of admission.Results: The ROC analysis shows that the best discrimination was provided by SAPS 2 score (AUROC=0.981), followed by APACHE II (AUROC=0.978) and SOFA (AUROC=0.911).Conclusions: SAPS 2 score was superior to the APACHE II and SOFA scores for predicting survival in patients with septic shock but a combination of factors must be taken in consideration to estimate the prognosis in the ICU.

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Section: Discussionmentioning

confidence: 99%

Assessment and comparison of 3 mortality prediction models SAPS II, APACHE II and SOFA for prediction of mortality in patients of sepsis

et al. 2017

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“…Some studies reported APACHE II as better than SAPS score in the prediction of mortality and morbidity associated with poisoning [30] while others [31] have found that the SOFA score was more useful and simpler to use than the APACHE II and SAPS II scores.…”

Section: Discussionmentioning

confidence: 99%

Acute Poisonings Admitted to a Tertiary Level Intensive Care Unit in Northern India: Patient Profile and Outcomes

Ahuja¹

2015

JCDR

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“…The World Health Organization has estimated that more than 300 million case of acute pesticide poisoning occur worldwide each year, and that most of these cases are due to OP intoxication. These OP compounds are likely to have more toxicity in developing countries due to its easy availability and less awareness which results in high morbidity and mortality (Kumar et al, 2010;Kim et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The Role of APACHE II, SOFA, Serum amylase and Lipase in Assessment of Severity and Outcome of Acute Organophosphorus Poisoning

Moussa

Mohamed

Hilal

et al. 2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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All right received. AbstractPoisoning with Organophosphate (OP) compounds is responsible for great morbidities and mortalities all over the world especially in developing countries including Egypt. Scoring systems have been continuously developed to predict outcomes in patients with severe illness, to improve resource allocation and to assist in clinical decision-making particularly for ICU patients. The quest for biomarkers in relation to OP compound poisoning started quite a long time back but cheap and easily measurable biomarkers having prognostic value is the need of the hour. The objective of this study is to evaluate the role of acute physiology and chronic health evaluation II (APACHE II) score, the Sequential Organ Failure Assessment (SOFA) score, serum amylase and lipase in assessing severity and outcome of acute organophosphorus poisoning. A retrospective and prospective study was carried out on 200 patients of acute OP poisoning admitted to the Poison Control Center (PCC), Ain Shams University Hospitals. Information after obtaining the permission of the director of PCC and the regional ethics committee was collected from the sheets and computerized data base of the patients, an informed written consent has been obtained from each patient or from his/her caregiver for inclusion in the prospective part of the study. APACHE II and SOFA scores were calculated to each patient admitted and biochemical analysis of serum amylase and lipase were estimated in the prospective part of the study. The results were revised, coded and organized for statistical analysis. The study results revealed 180 (90%) patients discharged and 20 (10%) patients died. The study showed that there were 76% of patients had APACHE II score ≤ 9, while 12.5% of patients had APACHE II score from 10 to 14, there were 8.5% of patients had APACHE II score from 15 to 24 and APACHE II score was > 24 in 3% of patients. SOFA score in 88.5%of patients was ≤ 6, while in 4.5% of patients SOFA score was from 7 to 9 and in 7%of patients SOFA score was > 9. Hyperamylasemia observed in 83.3% of died and 33.3% of died patients had increased lipase. There was significant difference between discharged and died patients as regards APACHE II score, SOFA Score, serum amylase and lipase. It could be concluded that SOFA score, APACHEII score, serum amylase and lipase had a role in assessment of severity of acute organophosphorus poisoning but only SOFA score, APACHEII score and serum amylase could be used as predictors of outcome. SOFA score is more useful in predicting mortality, and easier and simpler than the APACHEII and serum amylase. From the previous results, our study recommends that predictors of outcome (APACHE II score, SOFA score and serum amylase) should be assessed routinely and as early as possible to evaluate the severity, improve the course of management and deciding the pathway of care.

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Performance Assessment of the SOFA, APACHE II Scoring System, and SAPS II in Intensive Care Unit Organophosphate Poisoned Patients

Cited by 44 publications

References 19 publications

Assessment and comparison of 3 mortality prediction models SAPS II, APACHE II and SOFA for prediction of mortality in patients of sepsis

Assessment and comparison of 3 mortality prediction models SAPS II, APACHE II and SOFA for prediction of mortality in patients of sepsis

Acute Poisonings Admitted to a Tertiary Level Intensive Care Unit in Northern India: Patient Profile and Outcomes

The Role of APACHE II, SOFA, Serum amylase and Lipase in Assessment of Severity and Outcome of Acute Organophosphorus Poisoning

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