Performance assessment of displacement-field estimation of the human left atrium from 4D-CT images using the coherent point drift algorithm

Otani, Tomohiro; Shiga, Mikio; Endo, Shunsuke; Wada, Shigeo

doi:10.1016/j.compbiomed.2019.103454

Cited by 10 publications

(7 citation statements)

References 31 publications

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“…Vedula et al used this method by extracting points that lay on the blood-muscle interface and calculated the deformation field diffeomorphic registration algorithm, known as large deformation diffeomorphic metric mapping (LDDMM) 7 . Similar approaches have been used by other, as for instance Otani et al 8 and García-Villalba et al 9 , who used a coherent point drift algorithm. However, the algorithms developed in these studies were not validated with data from other modalities.…”

Section: Introductionmentioning

confidence: 89%

Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

et al. 2023

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Background Cardiac time-resolved CT (4D-CT) acquisitions provide high quality anatomical images of the heart. However, some cardiac diseases require assessment of blood flow in the heart. Diastolic dysfunction, for instance, is diagnosed by measuring the flow through the mitral valve (MV), while in atrial fibrillation, the flow through the left atrial appendage (LAA) indicates the risk for thrombus formation. Accurate validated techniques to extract this information from 4D-CT have been lacking, however. Methods To measure the flow rate though the MV and the LAA from 4D-CT, we developed a motion tracking algorithm that performs a nonrigid deformation of the surface separating the blood pool from the myocardium. To improve the tracking of the LAA, this region was deformed separately from the left atrium and left ventricle. We compared the CT based flow with 4D flow and short axis MRI data from the same individual in 9 patients. Results For the mitral valve flow, good agreement was found for the time span between the early and late diastolic peak flow (bias: <0.1 s). The ventricular stroke volume is similar compared to short-axis MRI (bias 3 ml). There are larger differences in the diastolic peak flow rates, with a larger bias for the early flow rate than the late flow rate. The peak LAA outflow rate measured with both modalities matches well (bias: −6 ml/s). Conclusions Overall, the developed algorithm provides accurate tracking of dynamic cardiac geometries resulting in similar flow rates at the MV and LAA compared to 4D flow MRI.

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Section: Introductionmentioning

confidence: 89%

Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

et al. 2023

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“…The displacement of the LA surface throughout the cardiac cycle was estimated through non-rigid point set registration using a coherent point drift algorithm (Myronenko and Song, 2010 ) adjusted for the estimation of LA motion, as described in our previous study (Otani et al, 2019 ). The estimated displacements of the LA surface and LV volume were temporally interpolated using the inverse Fourier expansion within fifth-order modes.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we used computational simulations to investigate a possible alteration of the LA hemodynamics by an LUL. Using our previously developed electrocardiogram-gated four-dimensional computed tomography (4D-CT) framework (Otani et al, 2016(Otani et al, , 2019, a personalized blood flow simulation in the LA was conducted for a lung cancer patient before and after an LUL. This study is the first to investigate the effect of an LUL on LA hemodynamics and shows they are altered in the PV stump and throughout the LA region.…”

Section: Introductionmentioning

confidence: 99%

“…The LA hemodynamics in atrial fibrillation have recently attracted attention, and several studies have conducted computational simulations of LA blood flow analysis aimed at clarifying causal relationships between LA hemodynamics and thrombosis (Otani et al, 2016 ; Bosi et al, 2018 ; Dillon-Murphy et al, 2018 ; Masci et al, 2019 , 2020 ; Dueñas-Pamplona et al, 2021 ). These studies have advanced computational approaches to modeling LA hemodynamics by considering anatomical LA geometries, physiological motions, and boundary conditions (Lantz et al, 2018 , 2019 ; Otani et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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On the Impact of Left Upper Lobectomy on the Left Atrial Hemodynamics

Otani

Yoshida

et al. 2022

Front. Physiol.

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The left atrium (LA) functions to transport oxygenated blood from the pulmonary veins (PVs) to the left ventricle (LV). LA hemodynamics has received much attention because thrombosis in the LA in pathological states, such as atrial fibrillation, is a major factor leading to thromboembolic stroke. In the last 5 years, multiple cohort studies have revealed that left upper lobectomy (LUL) with PV resection risks thrombus formation in the PV stump even in the normal LA without a history of cardiac disease; the causal mechanism is, however, an open question. The present study investigated the potential effect of an LUL on LA hemodynamics associated with thrombus formation through computational simulation using four-dimensional computed tomography (4D-CT) images. Time series of patient-specific LA geometries before and after LUL were extracted from the 4D-CT images and these motions were estimated through non-rigid registration. Adopting the LA geometries and prescribed moving wall boundary conditions, the LA blood flow was determined using a Cartesian-grid computational fluid dynamics solver. The obtained results show that the LUL resulted in blood flow impingement from the left and right PV inflows into the LA upper region throughout most of the cardiac cycle. This characteristic alteration of the LA hemodynamics generated fine-scale vortices with viscous energy dissipations, enhancing the flow stasis associated with thrombus formation in the PV stump. These findings show that an LUL affects the hemodynamics not only in the PV stump but also throughout the LA region. They also highlight the importance of computational analysis of LA hemodynamics in understanding the underlying mechanism of LUL-induced thrombus formation.

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“…62 Currently, computational flow dynamics in LA have been attempted using 4D CT data as the input. [63][64][65] The combination of both methods can expand the flexibility of the analysis, such as shortening 4D flow MRI scan time, improving spatial resolution, and applying surgical-simulation. 66…”

Section: Future Directionsmentioning

confidence: 99%

4D Flow MR Imaging of the Left Atrium: What is Non-physiological Blood Flow in the Cardiac System?

et al. 2022

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Most cardiac diseases cause a non-physiological blood flow pattern known as turbulence around the heart and great vessels, which further worsen the disease itself. However, there is no consensus on how blood flow can be defined in disease conditions. Especially, in the left atrium, the fact that vortex flow already exists makes this debate more complicated. 3D time-resolved phase-contrast (4D flow) MRI is expected to be able to capture blood flow patterns from multiple aspects, such as blood flow velocity, stasis, and vortex quantification. Previous studies have confirmed that physiological vortex flow is predominantly induced by the higher-volume flow from the superior left pulmonary vein. In atrial fibrillation, 4D flow MRI reveals a non-physiological blood flow pattern, which information may add value to well-established clinical risk factors. Currently, the research target of LA analysis has also widened to lung surgeons, pulmonary vein stump thrombosis after left upper lobectomy. 4D flow MRI is expected to be utilized for many more variable diseases that are currently unimaginable.

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Performance assessment of displacement-field estimation of the human left atrium from 4D-CT images using the coherent point drift algorithm

Cited by 10 publications

References 31 publications

Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

On the Impact of Left Upper Lobectomy on the Left Atrial Hemodynamics

4D Flow MR Imaging of the Left Atrium: What is Non-physiological Blood Flow in the Cardiac System?

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