This paper builds its arguments on the (re)interpretation of ‘human’ and its entanglements with nonhumans, namely ‘the others’, in the digital age, also called the information age, which started in the 1970s with the introduction of personal computers. Since the concept of humanness has prominently transformed into something innovative as a result of immense improvements in science and technology, and thereby society, terms such as human, nonhuman, posthuman, and transhuman including cyborgs, have emerged as concepts that require to be reinterpreted in the digital age. In a planet where cryptocurrency, artificial intelligence, 5G technology, autonomous vehicles, quantum computers, genetic engineering, edge computing, microchips, green tech, and hydrogen fuel cells are commonly regarded as innovative inventions of the 21st century, the positions of humans are decentralized and displaced from centralized to more peripheric spheres. Beginning from anthropocentrism, in other words human-centeredness, broadly defined as a thought process that makes humans the primary measure of everything, this paper exposes the (trans)formation of humans from anthropocentricism to posthumanism and paradoxically from posthumanism to transhumanism by drawing upon the philosophical discussions of Donna Haraway, Rosi Braidotti, Cary Wolfe, Francesca Ferrando and others. Unlike anthropocentricism, posthumanism, as a philosophical and critical theory, attempts to replace humankind by responding to the presence of anthropocentricism in the 21st century. On the other hand, whereas posthumanism, by rejecting any privileges founded on anthropocentric dominance, has challenged the notion that humans are the primary measure of everything on the planet since 1990s, transhumanism emphasizes the continuity of human improvement through technological means that attempt to enhance human capabilities beyond their current biological boundaries. By interrogating the socio-cultural existence of humans through epistemological and ontological viewpoints since the very beginning of humanism, namely a philosophy that places central emphasis on the human realm, this paper attempts to (re)define the place of humans in the digital age with a focus on the relationship between human and nonhuman beings and their entanglements.