Performance and haematological indices in rats exposed to monocrotophos contamination

Sunmonu, Taofik O.; Oloyede, O. B.

doi:10.1177/0960327110363441

Cited by 25 publications

(20 citation statements)

References 17 publications

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“…It can also be used to explain blood relating functions of chemical compounds/plant extract (Yakubu et al, 2007). The various haematological parameters investigated in this study are useful indices that can be employed to assess the toxic potentials of plant extracts/botanicals in living systems (Sunmonu and Oloyede, 2010). Such toxicity testing is relevant to risk evaluation as changes in the haematological system have higher predictive value for human toxicity, when data are translated from animal studies (Olson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effects of leaf and berry extracts of Phytolacca dioica L. on haematological and weight parameters of Wistar rats

Ashafa¹,

Sunmonu²,

Afolayan³

2011

Afr. J. Pharm. Pharmacol.

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The effect of aqueous leaf and berry extracts of Phytolacca dioica administered at 50, 100 and 200 mg/kg body weight for 14 days was investigated on haematology and weight parameters of Wistar rats. The extracts at all doses had no significant effect on the red blood cells (RBC), haemoglobin (HB), parked cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) when compared with the animals in the control group. In contrast, the extracts at all doses caused a progressive significant reduction in the serum levels of platelets, white blood cells (WBC), neutrophils and monocytes. Also, there was dosedependent significant increase in the serum levels of lymphocytes and a reduction in the level of eosinophils. Administration of the extracts at all doses investigated led to a significant reduction in the body weight, absolute organ weight and organ-body weight ratio. These observable alterations in some parameters were indications that the leaf and berry extracts of P. dioica possess slight toxicity. Therefore, the crude extracts from the leaf and berry may not be completely safe as oral remedies.

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Section: Discussionmentioning

confidence: 99%

Effects of leaf and berry extracts of Phytolacca dioica L. on haematological and weight parameters of Wistar rats

Ashafa¹,

Sunmonu²,

Afolayan³

2011

Afr. J. Pharm. Pharmacol.

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“…The use of haematological parameters to evaluate/predict the toxic effect of plant extracts or natural products on the living system of experimental animals has been widely documented (Ladokun, Ojezele, & Arojojoye, ; Sunmonu & Oloyede, ). In the present study, the AECDR exhibited selective systemic toxicity.…”

Section: Discussionmentioning

confidence: 99%

Fertility enhancing activity and toxicity profile of aqueous extract ofChasmanthera dependensroots in male rats

Quadri

Yakubu

2017

Andrologia

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This study evaluated the fertility-enhancing activity and safety of aqueous extract of Chasmanthera dependens root (AECDR) in male rats. In the fertility study, twenty, sodium arsenite (10 mg/kg) body weight (BW)-treated male rats (171.02 ± 3.36 g), assigned into four groups (I-IV), received 1 ml of distilled water (DW), 25, 50 and 100 mg/kg BW of AECDR for 60 days, whereas the control received DW. After 7 days of pairing with female rats (153.67 ± 2.24 g), spermatogenic, fertility, testicular function indices and enzymatic antioxidant activities were evaluated. The animal groupings in the toxicity study were similar to the fertility study except no administration of sodium arsenite. Sodium arsenite treatment-related decreases (p < .05) in the semen and sperm parameters, testicular function indices, antioxidant activities and female rat fertility indices were reversed/ameliorated by AECDR. AECDR significantly altered the function indices of the liver and kidney and the lipid profile and selectively altered the haematological parameters. There was no treatment-related histoarchitectural changes in the organs. Overall, the aqueous extract of C. dependens roots exhibited pro-spermatogenic, fertility enhancing, antioxidant and androgenic activities in male rats. It also exhibited functional toxicity. Therefore, the chronic use of AECDR may not be completely safe as oral remedy.

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“…Hematological parameters are useful indices that can be employed to assess the toxic potentials of plant extracts in living systems 20 . They can also be used to explain blood relating functions of chemical compound/plant extract.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the effects of aqueous extracts of viscum album (mistletoe) from three host plants on hematological parameters in albino rats.

Ladokun¹,

Ojezele²,

Oluwatosin³

2015

Afr H. Sci.

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Background: The extract of the leaves of Viscum album (mistletoe) has been used for centuries in traditional medicine in many parts of the world. However, like many medicinal plants, the belief that things of natural origin are safe may not be entirely true. The blood is a good indicator of health and pathological mirror of the entire body. Objective: Therefore, in this study, the acute effects of extracts of mistletoe, harvested from three hosts, on haematology indices of wistar albino rats was investigated. Methods: Graded doses (400, 800, 1600 and 3200mg/kg body weight) of aqueous extracts of mistletoe from three different host plants, coffee (Coffee arabica), kola (Kola nitida), cocoa (Theobromae cacao), were administered orally to wistar albino rats for 14 days. Full haematological parameters were evaluated on whole blood collected from rats twenty four hours after the administration of the last dose. Results: Mistletoe from kola caused a concentration dependent and statistically significant (p<0.05) reduction in platelets count in rats. Administration of mistletoe extract from cocoa and coffee led to reduction in hemoglobin concentration. Reductions in packed cell volume (PCV) and red blood cell (RBC) and increase in white blood cells (WBC) were also observed in rats administered all the extracts. Conclusion: Increase in the WBC count observed in rats administered mistletoe suggests that mistletoe extract contains agents that could stimulate the production of leucocytes and could serve as immune booster. However, there is need to be cautious in administration at high doses to prevent the risk of anaemia.

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Performance and haematological indices in rats exposed to monocrotophos contamination

Cited by 25 publications

References 17 publications

Effects of leaf and berry extracts of Phytolacca dioica L. on haematological and weight parameters of Wistar rats

Effects of leaf and berry extracts of Phytolacca dioica L. on haematological and weight parameters of Wistar rats

Fertility enhancing activity and toxicity profile of aqueous extract ofChasmanthera dependensroots in male rats

Comparative study on the effects of aqueous extracts of viscum album (mistletoe) from three host plants on hematological parameters in albino rats.

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