Performance advances in ion mobility spectrometry through combination with high speed vapor sampling, preconcentration and separation techniques

Dworzański, Jacek P.; Kim, Man-Goo; Snyder, A. Peter; Arnold, Neil; Meuzelaar, Henk L. C.

doi:10.1016/0003-2670(94)85027-5

Cited by 40 publications

(11 citation statements)

References 20 publications

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“…Precedent for such advances have been reported for derivatives of CAM instrumentation where dilution and preconcentration inlets where employed to provide straight response curves for log -log plots of response versus concentration. 26 Such strategies provide both models and confidence that the limitations in the desorber employed here were based upon design only and are not intrinsic barriers.…”

Section: Assessment Of Combined Elisa-ims Detectionmentioning

confidence: 99%

Detection ofsalmonella typhimurium by hand-held ion mobility spectrometer: A quantitative assessment of response characteristics

Smith

Eiceman

Walsh

et al. 1997

Field Analyt. Chem. Technol.

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Section: Assessment Of Combined Elisa-ims Detectionmentioning

confidence: 99%

Detection ofsalmonella typhimurium by hand-held ion mobility spectrometer: A quantitative assessment of response characteristics

Smith

Eiceman

Walsh

et al. 1997

Field Analyt. Chem. Technol.

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“…In an elegant set of experiments performed in a GC-IMS system, 12 it was clearly observed ( Figure 6 of reference 12) that the order of elution for the CWA simulants was the same in both the IMS and GC; thus, the GC separation correlates with that of the IMS. This conclusion is also based on common knowledge that the GC separation is based on volatility that is generally reduced with the molecular size and weight, while the IMS ion drifting time is based on ion mobility, which is similarly reduced with the molecular size and weight.…”

Section: Orthogonal Gc and Pfpd Separation For The Elimination Of Falmentioning

confidence: 99%

“…Consequently, considerable effort was devoted to the coupling of both the IMS [12][13][14] and the flame photometric detector (FPD) 15 with a second dimension of separation of a gas chromatograph (GC). Ideally, if the separation technique, such as GC, is orthogonal (independent from and does not relate) to the detection technique (IMS or FPD), the total system separation power could be markedly increased and become the multiplicity of the separation powers of both techniques.…”

Section: Introductionmentioning

confidence: 99%

Fast GC-PFPD system for field analysis of chemical warfare agents

Frishman

Amirav

2000

Field Analyt. Chem. Technol.

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A fast gas chromatograph (GC) equipped with a pulsed‐flame photometric detector (PFPD) was designed and built with the intention of facilitating field analysis of the full range of chemical warfare agents (CWA). This GC‐PFPD system was tested with five organophosphorus and organosulfur CWA simulants that cover the volatility range of common CWA. Fast repetitive analysis was demonstrated with a cycle time as short as 30 s, combined with very low detection limits of 20 ng/m3 for organophosphorus CWA simulants and 200 ng/m3 for organosulfur compounds. With a longer analysis time of 80 s, a 3‐ng/m3 detection limit was demonstrated for DMMP. In the GC‐PFPD system, the separation power of each of these techniques is orthogonal and independent; thus, this hyphenated combination is characterized by a very low false‐alarm rate, combined with CWA identification capability at the molecular level. The large improvement in system selectivity is demonstrated in the direct analysis of a low level of triethylphosphate in the headspace of diesel fuel without any interference. The system inlet was heated and the sample path was inert without any metal, enabling fast response time and low detection limits for a low volatility agent such as VX. The same fast GC‐PFPD system could also be quickly and easily switched to a continuous sampling “sniff” mode of operation with 2‐s response time. Alternatively, it could be operated in a novel mode of thermally modulated inlet (TMI) that provided intermediate results between those of GC and “sniff” in terms of the trade‐off of response time and performance. The fast GC‐PFPD system is also characterized by low average hydrogen consumption (about 4 ml/min), small size, and low weight. No attempt was made to complete the system in terms of portable control electronics. The advantages and unique features of this system, as well as the importance of CWA identification at the molecular level, are discussed. © 2000 John Wiley & Sons, Inc. Field Analyt Chem Technol 4: 170–194, 2000

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“…In addition, a major advantage of the instrument is that it contains an automatic attenuation control, which extends the linear dynamic range of the instrument. 21 The narrow linear dynamic range of IMS has been one of its primary limitations. Disadvantages of operating the GC/ IMS under reduced pressures are that both chromatographic and ion mobility spectrometric resolution are decreased and the sensitivity of the IMS is reduced due to the low-pressure operation of the ionization region and drift tube.…”

Section: Portable Gc/imsmentioning

confidence: 99%

Capabilities and limitations of ion mobility spectrometry for field screening applications

Hill

Simpson

1997

Field Analyt. Chem. Technol.

104

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Performance advances in ion mobility spectrometry through combination with high speed vapor sampling, preconcentration and separation techniques

Cited by 40 publications

References 20 publications

Detection ofsalmonella typhimurium by hand-held ion mobility spectrometer: A quantitative assessment of response characteristics

Detection ofsalmonella typhimurium by hand-held ion mobility spectrometer: A quantitative assessment of response characteristics

Fast GC-PFPD system for field analysis of chemical warfare agents

Capabilities and limitations of ion mobility spectrometry for field screening applications

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