Perforation of Acellular Dermal Matrices Increases the Rate of Cellular Invasion

Osoria, Hector L.; Jacoby, Adam; Hooper, Rachel C.; Derrick, Kadria N; Patel, Vishal; Hernandez, Karina A.; Boers, Sophie A.M.; Asanbe, Ope; Elshazly, Tarek; Sasson, Arielle; Spector, Jason A.

doi:10.1097/01.prs.0000455347.89834.11

Cited by 3 publications

(10 citation statements)

References 3 publications

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“…1,5,9,13 (Figure 1) Compared to integral matrix patches, meshed patches showed an increased rate of cellular invasion without reducing tensile strength: indeed, the expanded surface of the mesh structure showed a better adherence, and the increased egress of fluid was supposed to be associated with decreased risk of infection. 7,10,11 Human ADMs have been also used in contaminated wound bed fields, showing good resistance to colonization and infection. 11,13 The selected hADM can be fixed with resorbable stiches and grafted alone or in combination with homologous skin grafts for temporary coverage.…”

Section: Advanced Dressing Proceduresmentioning

confidence: 99%

“…A properly designed decellularization process allows to preserve the structural integrity of the tissue, ensuring the regeneration of an intact vasculature, resulting in human or biological acellular dermal matrices (ADMs). Given that, human acellular dermal matrices (hADMs) meet the criteria of an “ideal scaffold”, defined as a substrate which is properly recognized by host cells and is fully incorporated by the host tissue after grafting 7‐11 . The hADMs are indeed capable to stimulate a rapid healing and the growth of a new tissue with enhanced pliability.…”

Section: Introductionmentioning

confidence: 99%

“…Surgeons and physicians progressively developed multiple techniques for the hADMs use, tailored to specific requirements. [9][10][11][12][13][14][15][16][17][18][19] As a consequence, the demand for hADMs, especially lyophilized (ie, freezedried) hADMs, is currently growing worldwide and is addressed to Tissue Establishments or Commercial Companies. 7,8,11 In Europe, hADMs are considered "human products" as per the European regulations on tissue transplants, thus can beonly donated, after processing and release by Tissue Establishments (ie, skin banks).…”

mentioning

confidence: 99%

“…Given that, human acellular dermal matrices (hADMs) meet the criteria of an "ideal scaffold", defined as a substrate which is properly recognized by host cells and is fully incorporated by the host tissue after grafting. [7][8][9][10][11] The hADMs are indeed capable to stimulate a rapid healing and the growth of a new tissue with enhanced pliability. This bring clear advantages in terms of clinical outcome: compared to those induced by animal-derived ADMs, the regenerated tissue obtained after hADMs grafting exhibits superior long-term functionality and appearance.…”

mentioning

confidence: 99%

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The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Tognetti

Pianigiani

Ierardi

et al. 2021

Dermatologic Therapy

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Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head-and-neck, oral cavity, legs) are particularly challenging and can often be delayed due to local and systemic factors. In case of deep wounds and/or hard-to-heal wounds, grafting of dermal acellular matrices (ADM) is often needed. Though a great variety of synthetic and semisynthetic dermal and skin equivalents are available, viable human dermis, is still considered the most physiological alternative to replace the loss of autologous dermis, by acting as a physiological scaffold that add structural support to soft tissues. To date, human ADMs (hADMs) have been employed in the reconstruction of skin defects affecting almost all body sites, ranging from visceral sites to the skin and subcutaneous tissues. This review aims to investigate the use of hADM at different body sites and their peculiar advantages. A literature search was using the search terms "acellular dermal matrices", "dermal regeneration", "advances wound healing", "human acellular dermal matrices surgery". A total of 50 out of 150 papers was included. Based on the current body if evidence, hADMs appear to bring several advantages, such as: protection of deep structures (eg, tendons, bones, cartilage and nerves); stimulation of a functional new dermis (rather than a scar); reduction of wound closure time; control of pain and exudate. Finally, hADMs may represent the best treatment option for hard-to-heal wound not only in terms of efficacy and patient satisfaction bout also in terms of sanitary costs, especially across Europe, where hADMs cannot be commercialized as medical devices.

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Section: Advanced Dressing Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Tognetti

Pianigiani

Ierardi

et al. 2021

Dermatologic Therapy

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“…In fact, the decreased time for incorporation coupled with improved egress of fluid may be associated with decreased risk for infection and seroma. 9 The ability for ADM to become vascularized and remodeled by autologous cells is an impetus behind its increasing use in contaminated fields. The perceived resistance of ADM to infection is a consequence of its biointegration, not sterility.…”

Section: Introductionmentioning

confidence: 99%

Acellular Dermal Matrices: Applications in Plastic Surgery

Tork

Jefferson

Janis

2019

Seminars in Plastic Surgery

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Modern advances in tissue engineering have transformed the plastic surgeon's management strategies across a wide variety of applications. Comprehension of the fundamentals of biologic constructs is critical to navigating the available armamentarium. It is essential that plastic surgeons become familiar with some of the existing methods for utilizing biologics as well as the advantages and limitations to their use. In this article, the authors describe the basic science of biologics with a focus on acellular dermal matrices (ADMs), and review the recent evidence behind their use for a variety of reconstructive and aesthetic purposes. The review is organized by system and examines the common indications, techniques, and outcomes pertaining to the application of ADMs in select anatomic areas. The final section briefly considers possible future directions for using biologics in plastic and reconstructive surgery.

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