Perforating granuloma annulare mimicking papulonecrotic tuberculid

Abstract

A case is reported of a patient presenting lymph node tuberculosis and cutaneous lesions resembling papulonecrotic tuberculid, but histologically compatible with perforating granuloma annulare and which responded satisfactorily to antituberculous therapy. This is probably one of the first reports of the association of perforating granuloma annulare and tuberculosis, and it is important therefore to highlight the relevance of this disorder in the differential diagnosis of papulonecrotic tuberculid and to raise the hypothesis that this entity should also be considered to be a variant of tuberculid.

Generalized perforating granuloma annulare associated with latent tuberculosis successfully treated with isoniazid: case report and review

“…This lack of diagnostic evaluation underlies the lack of awareness of the association between GPGA and tuberculosis. Association between PGA and tuberculosis has also been reported in only one case of localized PGA on the extremities associated with lymph node tuberculosis, but not latent tuberculosis [2].…”

“…Perforating granuloma annulare (PGA) is an extremely rare clinical and histological variant of granuloma annulare (GA), localized most commonly on upper extremities and dorsal hands [1][2][3]. Studies suggest the prevalence of PGA to be up to 5% of GA [1].…”

Perforating Granuloma Annulare Mimicking Papulonecrotic Tuberculid

“…To the best of our knowledge, there are two cases of PGA mimicking PNT clinically or histologically ( Table 1 ) 14 15 . One case of PGA is associated with lymph node tuberculosis infection 14 . In that case, the diagnosis of PGA was not difficult because typical histologic findings of PGA were seen.…”

Transepidermal elimination of mucin is a very common but not yet reported phenomenon in digital myxoid cysts: a study of 35 cases

“…The nature of these elements varies in literature. Examples include pilomatricomas, follicular cysts, granuloma annulare, elastic fibers, collagen, leishmanias, foreign‐body type granulomas, carcinomatous cells or amyloids…”