Perforated neonatal appendicitis: A rare presentation of Hirschsprung disease

Subramaniam, Viknesh; Shah, Mohd Shahrulsalam Mohd; Faiziah, Wan Abdul Rahman Wan

doi:10.1016/j.epsc.2021.101935

Cited by 1 publication

(7 citation statements)

References 2 publications

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“…Table 4 provides an overview of the identified relevant comorbidities. As demonstrated, Hirschsprung disease was found in eight (3%) of the patients 25,59,86,114,115,129 . In all but one, it concerned perforated appendicitis.…”

Section: Resultsmentioning

confidence: 75%

“…With cross‐referencing, eight additional eligible articles were identified. In total, 131 articles were included in this systematic review 3,6,12–140 . Figure 1 provides the PRISMA flowchart.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of these complications was minor (CD grades I–II): N = 5 surgical site infection, and N = 3 (paralytic) ileus or slow peristalsis, N = 8 other. The remainder of complications was major (CD grades III–IV): N = 2 adhesive ileus requiring secondary surgery, N = 1 wound dehiscence requiring surgery, N = 1 secondary surgery due to perforation with NEC as underlying pathology, N = 1 secondary surgery due to intestinal stricture requiring subtotal resection with NEC as underlying pathology, N = 1 secondary surgery with placement of a transverse colostomy with Hirschsprung disease as underlying pathology 22,25,98,118 . An overview is provided in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…with placement of a transverse colostomy with Hirschsprung disease as underlying pathology. 22,25,98,118 An overview is provided in Table 2.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

“…As demonstrated, Hirschsprung disease was found in eight (3%) of the patients. 25,59,86,114,115,129 In all but one, it concerned perforated appendicitis. The length of the aganglionic segment was provided in In addition, we evaluated potential treatment strategies and patient characteristics that may be associated with poor outcome.…”

Section: Comorbiditymentioning

confidence: 99%

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Appendicitis and its associated mortality and morbidity in infants up to 3 months of age: A systematic review

The,

Derikx

et al. 2023

Health Science Reports

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Background and AimsAlthough appendicitis is rare in young infants, the reported mortality is high. Primary aim of this systematic review was to provide updated insights in the mortality and morbidity (postoperative complications, Clavien‐Dindo grades I–IV) of appendicitis in infants ≤3 months of age. Secondary aims comprised the evaluation of patient characteristics, diagnostic work‐up, treatment strategies, comorbidity, and factors associated with poor outcome.MethodsThis systematic review was reported according to the PRISMA statement with a search performed in Pubmed, Embase and Web of Science (up to September 5th 2022). Original articles (published in English ≥1980) reporting on infants ≤3 months of age with appendicitis were included. Both patients with abdominal appendicitis and herniated appendicitis (such as Amyand's hernia) were considered. Data were provided descriptively.ResultsIn total, 131 articles were included encompassing 242 cases after identification of 4294 records. Overall, 184 (76%) of the 242 patients had abdominal and 58 (24%) had herniated appendicitis. Two‐hundred (83%) of the patients were newborns (≤28 days) and 42 (17%) were infants between 29 days and ≤3 months of age. Either immediate, or after initial conservative treatment, 236 (98%) patients underwent surgical treatment. Some 168 (69%) patients had perforated appendicitis. Mortality was reported in 20 (8%) patients and morbidity in an additional 18 (8%). All fatal cases had abdominal appendicitis and fatal outcome was relatively more often reported in newborns, term patients, patients with relevant comorbidity, nonperforated appendicitis and those presented from home.ConclusionMortality was reported in 20 (8%) infants ≤3 months of age and additional morbidity in 18 (8%). All patients with fatal outcome had abdominal appendicitis. Several patient characteristics were relatively more often reported in infants with poor outcome and adequate monitoring, early recognition and prompt treatment may favour the outcome.

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Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…with placement of a transverse colostomy with Hirschsprung disease as underlying pathology. 22,25,98,118 An overview is provided in Table 2.…”

Section: Baseline Characteristicsmentioning

confidence: 99%