Perforated intestinal leiomyosarcoma as a metastasis of uterine leiomyosarcoma: a case report

Abstract

IntroductionUterine leiomyosarcomas are relatively uncommon soft tissue neoplasms and rarely metastases to small bowel. In the current case; a patient is suffering from intestinal perforation due to metastatic leiomyosarcoma of the small bowel.Case presentationA 59-year-old woman underwent a modified radical mastectomy for infiltrating ductal cancer of the breast six years ago and a total abdominal hysterectomy for leiomyosarcoma of the uterus two years ago. About 2400 cGy total dose radiotherapy has also been applied after total hysterectomy for bone metastasis of breast cancer. She admitted to our clinic with the complaints of acute abdomen due to perforated small bowel metastasis of leiomyosarcoma during the radiotherapy. Laparotomy was performed and leiomyosarcoma of the ileum was removed totally. Histopathologic examination of the specimen confirmed the presence of the leiomyosarcoma in intestinal tissue samples.ConclusionWe aimed to present this unusual case which perforated presentation of the intestinal metastasis of uterine leiomyosarcoma.

Obstructive Small Bowel Metastasis from Uterine Leiomyosarcoma: A Case Report

“…Uterine leiomyosarcoma can invade small bowel by direct extension, hematogenous route, implantation, or via lymphatic route [ 5 ]. Acute abdomen (small bowel obstruction or perforation) secondary to metastatic uterine leiomyosarcoma to small bowel is not well known and has been documented by only four case reports till date [ 6 ]. Small bowel metastasis in uterine leiomyosarcoma is usually a sign of extensive disease and poor prognosis.…”

Perforation of intestinal leiomyosarcoma: A case report

“…We searched literatures about a perforation of intestinal leiomyosarcoma in the PubMed, which used WHO redefinition, from 1999 to now. We could find one literature which reported the perforation of small intestine by leiomyosarcoma as a metastasis of uterine leiomyosarcoma [ 8 ]. The same point between the case and our patient was that leiomyosarcoma invaded normal ileum all through the intestine wall from serosa into the mucosa regardless of the primary lesion and the size.…”

Pulmonary metastasis from uterine leiomyosarcoma in a patient with limited cutaneous systemic scleroderma

“…It develops distant metastases both alone or in association within pelvis. Uterine leiomyosarcoma usually metastasizes to the lungs, peritoneal cavity, followed by the retroperitoneum, liver, and bone . Pulmonary metastases from uterine leiomyosarcoma are sometimes detected incidentally, and almost of them are found by chest radiograph and chest CT scan .…”

“…Uterine leiomyosarcoma usually metastasizes to the lungs, peritoneal cavity, followed by the retroperitoneum, liver, and bone. [9][10][11][12][13][14] Pulmonary metastases from uterine leiomyosarcoma are sometimes detected incidentally, and almost of them are found by chest radiograph and chest CT scan. 15 We herein a case, who was diagnosed as having limited cutaneous systemic scleroderma (lcSSc), presented with incidentally detected pulmonary metastasis of uterine leiomyosarcoma.…”