Perforated appendicitis: Prospective outcome analysis for 150 children

Fishman, Steven J.; L, Pelosi; Klavon, Susan; OʼRourke, Edward J.

doi:10.1053/jpsu.2000.6924

Cited by 91 publications

(58 citation statements)

References 9 publications

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“…Pain was the consistent symptom present in all the cases. Pain was associated with vomiting and fever, fever was above 102˚f and associated with chills but without rigor in perforated appendicitis, similar findings were also observed by other authors [4,6,8,25,33,34]. Diarrhea was observed in 14(11.27%) cases.…”

Section: IVsupporting

confidence: 86%

“…Males outnumbered females by a ratio of 1.47:1 in the present study. This male preponderance was also noted by other authors [6,8,9,12,15,25,28,29,30,31,32,34] .The high incidence in male is probably because males are more exposed to environmental and dietary changes than females.…”

Section: IVsupporting

confidence: 83%

“…Appendicitis is uncommon in children younger than 5 years of age and extremely rare in infants younger than 6 month of age was observed by other authors [4,6,7,8,12,15,25]. In children below 10 years of age there is wide communication of appendix with caecum, such a configuration of appendix in this age makes obstruction of lumen unlikely.…”

Section: IVmentioning

confidence: 79%

See 2 more Smart Citations

“Perforated Appendicitis In Children”

Gajbhiye¹,

Dakhore²,

Khathod³

2013

IOSR-JDMS

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Section: IVsupporting

confidence: 86%

Section: IVsupporting

confidence: 83%

See 1 more Smart Citation

“Perforated Appendicitis In Children”

Gajbhiye¹,

Dakhore²,

Khathod³

2013

IOSR-JDMS

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“…기존의 연구에 따르면, 소아 천공성 충수염에서 수술 후 정맥용 항생제를 다중으로 짧은 기간 사용한 후, 경구 항 생제를 사용하는 것이 좋다는 보고도 있었고 [9,15], 수술 후 에 세 가지 항생제를 사용하는 것이 좋다는 주장도 있었다 [10]. 최근의 광범위 항생제의 단일 약물 요법과 다중 약물 요법을 비교한 연구에서 두 요법의 치료 효과는 차이가 나지 않으며, 비용면에서 단일 약물 요법이 우월하다고 보고하였 다 [11].…”

Section: 고 찰unclassified

“…였으나 [9,10], 최근에는 광범위 항생제를 단독 투여하는 요 법이 두 가지 이상의 항생제를 투여하는 다중요법만큼 효과 가 있는 것으로 보고되고 있다 [11]. 저자들은 소아에 발생한 천공성 충수염에서 piperacillin-tazobactam (PT) 단일요 법과 cefotaxime과 metronidazole (CM) 다중요법으로 항 생제 치료한 환자들의 재원 기간, 치료 결과, 총 진료비 등을 비교해 보았다.…”

unclassified

Postoperative Monotherapy with Piperacillin-Tazobactam versus Multidrug Therapy with Cefotaxime and Metronidazole for Perforated Appendicitis in Children: A Case-Control Study

Chun

Kim

et al. 2015

J Korean Assoc Pediatr Surg

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Purpose: Recent data suggest that monotherapy with a broad-spectrum antibiotic may be as efficacious as, and potentially less costly than, standard multi-drug therapy. We compared mono-therapy with intravenous piperacillin-tazobactam (PT) with multi-drug therapy with cefotaxime and metronidazole (CM) in aspect of postoperative complications and hospital stay. Methods: We reviewed the hospital records and medical costs of the pediatric patients who were managed for perforated appendicitis between April 2013 and May 2014 retrospectively. Results: Forty-six patients with laparoscopic appendectomy for perforated appendicitis were included in our study. PT group was 20 and CM group was 26 patients. On admission, there were no significance in sex distribution, duration of symptoms, leukocyte count, and CRP levels. At postoperative third, fifth, and seventh day of each regimen, PT group have no statistical difference with CM group in leukocyte count, percentage of neutrophil, and CRP. There was no difference in abscess formation rate, wound infections, and hospital stay between two groups. There was only one patient who was readmitted with elevation of CRP and leukocyte count in CM group. Conclusion: Daily dosing with the mono-therapy of PT offers as efficient as multi-drug therapy of CM. To evaluate the efficacy of broad-spectrum antibiotics monotherapy in perforated appendicitis children, the cohort included more patients should be needed.

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Early vs Interval Appendectomy for Children With Perforated Appendicitis

Blakely¹,

Williams²,

Dassinger³

et al. 2011

Arch Surg

143

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Setting: A tertiary-referral urban children's hospital.Patients: A total of 131 patients younger than 18 years with a preoperative diagnosis of perforated appendicitis.Interventions: Early appendectomy (within 24 hours of admission) vs interval appendectomy (6-8 weeks after diagnosis).Main Outcome Measures: Time away from normal activities (days). Secondary outcomes included the overall adverse event rates and the rate of predefined specific adverse events (eg, intra-abdominal abscess, surgical site infection, unplanned readmission).Results: Early appendectomy, compared with interval appendectomy, significantly reduced the time away from normal activities (mean, 13.8 vs 19.4 days; PϽ.001). The overall adverse event rate was 30% for early appendectomy vs 55% for interval appendectomy (relative risk with interval appendectomy, 1.86; 95% confidence interval, 1.21-2.87; P=.003). Of the patients randomized to interval appendectomy, 23 (34%) had an appendectomy earlier than planned owing to failure to improve (n=17), recurrent appendicitis (n=5), or other reasons (n=1). Conclusions:Early appendectomy significantly reduced the time away from normal activities. The overall adverse event rate after early appendectomy was significantly lower compared with interval appendectomy.

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Perforated appendicitis: Prospective outcome analysis for 150 children

Cited by 91 publications

References 9 publications

“Perforated Appendicitis In Children”

“Perforated Appendicitis In Children”

Postoperative Monotherapy with Piperacillin-Tazobactam versus Multidrug Therapy with Cefotaxime and Metronidazole for Perforated Appendicitis in Children: A Case-Control Study

Early vs Interval Appendectomy for Children With Perforated Appendicitis

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