Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery

Li, Xiao; Sui, Zhongguo; Li, Xin; Xu, Wei; Guo, Qie; Sun, Jialin; Jing, Fanbo

doi:10.2147/ijn.s164905

Cited by 35 publications

(42 citation statements)

References 137 publications

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“…Perfluorochemicals (PFCs) are inert and highly fluorinated organic compounds that can dissolve large volumes of respiratory gases including oxygen, O 2 (Li et al, 2018). High gas solubilities of PFCs forms the foundation for an abiotic form for intravascular oxygen delivery.…”

Section: Ultrasound Interaction With Nanoparticlesmentioning

confidence: 99%

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Tharkar

Varanasi

Wong

et al. 2019

Front. Bioeng. Biotechnol.

139

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While ultrasound is most widely known for its use in diagnostic imaging, the energy carried by ultrasound waves can be utilized to influence cell function and drug delivery. Consequently, our ability to use ultrasound energy at a given intensity unlocks the opportunity to use the ultrasound for therapeutic applications. Indeed, in the last decade ultrasound-based therapies have emerged with promising treatment modalities for several medical conditions. More recently, ultrasound in combination with nanomedicines, i.e., nanoparticles, has been shown to have substantial potential to enhance the efficacy of many treatments including cancer, Alzheimer disease or osteoarthritis. The concept of ultrasound combined with drug delivery is still in its infancy and more research is needed to unfold the mechanisms and interactions of ultrasound with different nanoparticles types and with various cell types. Here we present the state-of-art in ultrasound and ultrasound-assisted drug delivery with a particular focus on cancer treatments. Notably, this review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions. Furthermore, this review presents safety considerations related to ultrasound technology and gives recommendations in the context of system design and operation.

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Section: Ultrasound Interaction With Nanoparticlesmentioning

confidence: 99%

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Tharkar

Varanasi

Wong

et al. 2019

Front. Bioeng. Biotechnol.

139

View full text Add to dashboard Cite

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“…Conventional gas-filled microbubbles as UCAs could enhance the backscattering signal of blood by non-linear oscillations under ultrasound but are not suitable for tissue molecular evaluation due to its limitation in intravascular imaging and poor stability [35]. Compared with gas-filled agent, the liquid fluorocarbon-filled PLGA nanocapsules have acoustic stability with prolonged circulation half-time [16]. Besides, our previous research found that Au nanoshells have good reflection properties because of its high atomic number and density [36].…”

Section: Resultsmentioning

confidence: 99%

“…As we all known, due to its outstanding biocompatibility and biodegradability, poly (lactic-co-glycolic acid) (PLGA)-based nanostructures have been widely investigated for use in drug-delivery systems and molecular imaging [13, 14]. Perfluorooctyl bromide (PFOB), a liquid perfluorocarbons (PFCs), has been encapsulated within polymeric shells such as PLGA to develop novel ultrasound contrast agents (UCAs) because of its high oxygen solubility, hydrophobicity, and lipophobicity [15, 16]. In addition, superparamagnetic iron oxide nanoparticles (SPIOs) have received great attention as MR molecular probes to obtain anatomical information in living organisms due to their great biocompatibility and excellent contrast enhancement [17–19].…”

Section: Introductionmentioning

confidence: 99%

Her2-Functionalized Gold-Nanoshelled Magnetic Hybrid Nanoparticles: a Theranostic Agent for Dual-Modal Imaging and Photothermal Therapy of Breast Cancer

et al. 2019

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Targeted theranostic platform that integrates multi-modal imaging and therapeutic function is emerging as a promising strategy for earlier detection and precise treatment of cancer. Herein, we designed targeted gold-nanoshelled poly (lactic-co-glycolic acid) (PLGA) magnetic hybrid nanoparticles carrying anti-human epidermal growth factor receptor 2 (Her2) antibodies (Her2-GPH NPs) for dual-modal ultrasound (US)/magnetic resonance (MR) imaging and photothermal therapy of breast cancer. The agent was fabricated by coating gold nanoshell around PLGA nanoparticles co-loaded with perfluorooctyl bromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs), followed by conjugating with anti-Her2 antibodies. Cell-targeting studies demonstrated receptor-mediated specific binding of the agent to Her2-positive human breast cancer SKBR3 cells, and its binding rate was significantly higher than that of Her2-negative cells ( P < 0.001). In vitro, the agent had capabilities for contrast-enhanced US imaging as well as T 2 -weighted MR imaging with a relatively high relaxivity ( r 2 = 441.47 mM −1 s −1 ). Furthermore, the Her2 functionalization of the agent prominently enhanced the US/MR molecular imaging effect of targeted cells by cell-specific binding. Live/dead cell assay and targeted photothermal cytotoxicity experiments confirmed that Her2-GPH NPs could serve as effective photoabsorbers to specifically induce SKBR3 cell death upon near-infrared laser irradiation. In summary, Her2-GPH NPs were demonstrated to be novel targeted theranostic agents with great potential to facilitate early non-invasive diagnosis and adjuvant therapy of breast cancer. Electronic supplementary material The online version of this article (10.1186/s11671-019-3053-4) contains supplementary material, which is available to authorized users.

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“…summarized the applications of PFOB NPs for US contrast imaging and drug delivery. [ 117 ] They concluded that PFOB NPs coated with lipids were more useful for drug delivery and that PFOB NPs coated with polymers were more preferable for US contrast imaging. Moreover, NPs made up of liquid PFOB and PLGA‐COOH or PLGA‐PEG‐COOH could offer good tumor‐selective US enhancement.…”

Section: Nps For Us Imagingmentioning

confidence: 99%

Fundamentals and applications of nanoparticles for ultrasound‐based imaging and therapy

et al. 2020

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Ultrasonography (US) is frequently applied in clinical imaging because of its inherent merits compared with those of other imaging methods. Nanoparticle (NP)‐based imaging and therapeutic modalities have been widely used because of their unique functionalities and high performance. The report is mainly about the classifications and applications of NPs for US‐based theranostic biomedicine. The US‐based applications include single‐modality US imaging, multimodality US imaging, high‐intensity focused US, US‐triggered drug release, US‐enhanced gene transfection, and US‐irradiated sonodynamic therapy. In addition, current challenges, including the biological effects and biosafety, are discussed in this interview. NPs have tremendous potential as a US‐based theranostic tool and have revealed a new direction in cancer therapy.

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Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery

Cited by 35 publications

References 137 publications

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Her2-Functionalized Gold-Nanoshelled Magnetic Hybrid Nanoparticles: a Theranostic Agent for Dual-Modal Imaging and Photothermal Therapy of Breast Cancer

Fundamentals and applications of nanoparticles for ultrasound‐based imaging and therapy

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