Perfluorooctane sulfonate induced neurotoxicity responses associated with neural genes expression, neurotransmitter levels and acetylcholinesterase activity in planarians Dugesia japonica

Yuan, Zuoqing; Shao, Xinxin; Miao, Zili; Zhao, Baisuo; Zheng, Ziyang; Zhang, Jianyong

doi:10.1016/j.chemosphere.2018.05.011

Cited by 40 publications

(24 citation statements)

References 51 publications

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“…Exposure of fish to some PFAS has also been associated with perturbation of the HPT axis. Zebrafish embryos exposed to perfluorododecanoic acid (1.2 mg/L) experienced growth reduction accompanied by dysregulation in the expression of several genes associated with thyroid function (Zhang et al 2018). A similar study with 0.5 mg PFOS/L caused decreased growth, decreased thyroid hormone levels, and downregulation of HPT axis genes (Kim et al 2011).…”

Section: Accepted Articlementioning

confidence: 94%

“…Short-term in vivo assays with pathway-based responses, including transcriptomic, proteomic and metabolomic measurements, are further advanced in terms of ecological coverage/application than computational and in vitro NAMs. Recent progress from both technical and conceptual perspectives have been promising in terms of increasing taxonomic representation and types of environmental stressors that can be addressed with these omic-based assays (Leung 2018;Martyniuk 2018;Song et al 2018;Zhang et al 2018;Gouveia et al 2019;Schuttler et al 2019). While there have been some short-term in vivo/toxicogenomic studies with different PFAS in non-mammalian vertebrates (e.g., Huang et al 2012;Dusgupta et al 2019;Lee et al 2019;Khazaee et al 2020), this is an area where work with additional PFAS and species would be warranted to help identify biological perturbations of potential concern.…”

Section: Accepted Articlementioning

confidence: 99%

See 1 more Smart Citation

Assessing the Ecological Risks of Per‐ and Polyfluoroalkyl Substances: Current State‐of‐the Science and a Proposed Path Forward

Ankley

Cureton

Hoke

et al. 2020

Enviro Toxic and Chemistry

213

150

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Per-and poly-fluoroalkyl substances (PFAS) encompass a large, heterogenous group of chemicals of potential concern to human health and the environment. Based on information for a few relatively well understood PFAS such as perfluorooctane sulfonate and perfluorooctanoate, there is ample basis to suspect that at least a subset can be considered persistent, bioaccumulative, and/or toxic. However, data suitable for determining risks in either prospective or retrospective assessments are lacking for the majority of PFAS. In August 2019, the Society of Environmental Toxicology and Chemistry sponsored a workshop that focused on the state-of-the-science supporting risk assessment of PFAS. This paper summarizes discussions concerning ecotoxicology and ecological risks of PFAS. First, we summarize currently available information relevant to problem formulation/prioritization, exposure, and hazard/effects of PFAS in the context of regulatory and ecological risk assessment activities from around the world. We then describe critical gaps and uncertainties relative to ecological risk assessments for PFAS and propose approaches to address these needs. Recommendations include the development of more comprehensive monitoring programs to support exposure assessment, an emphasis on research to support the formulation of predictive models for bioaccumulation, and the development of in silico, in vitro, and in vivo methods to efficiently assess biological effects for potentially sensitive species/endpoints. Addressing needs associated with assessing the ecological risk of PFAS will require cross-disciplinary approaches that employ both conventional and new methods in an integrated, resource-effective manner.

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Section: Accepted Articlementioning

confidence: 94%

Section: Accepted Articlementioning

confidence: 99%

Assessing the Ecological Risks of Per‐ and Polyfluoroalkyl Substances: Current State‐of‐the Science and a Proposed Path Forward

Ankley

Cureton

Hoke

et al. 2020

Enviro Toxic and Chemistry

213

150

View full text Add to dashboard Cite

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“…Dopamine was decreased in D. japonica exposed to 0.5 mg/L (1 µM) PFOS but increased at all doses between 0.5 and 10 mg/L (20 µM) after 1 day of exposure; it was significantly increased on day 4 of all exposed and continued to be increased after 10 days in all doses except 5 mg/L (10 µM) ( Table 2 A) [ 45 ]. Interestingly, this is different than that found in C. elegans , where dopamine was decreased after exposure to PFOS [ 30 ].…”

Section: Invertebrate Species Used To Study Neurotoxicity Of Pfasmentioning

confidence: 99%

“…This discrepancy could be due to differences in accumulation between D. japonica and C. elegans . In D. japonica , serotonin was affected after one day of exposure, with 0.5 mg/L PFOS increasing serotonin levels and 1 mg/L decreasing it ( Table 2 A) [ 45 ]. Interestingly, it was decreased at both exposure levels and increased at 5 mg/L and 10 mg/L after 4 days of exposure, while only the 0.5 mg/L and 10 mg/L had significantly increased serotonin after 10 days ( Table 2 A) [ 45 ].…”

Section: Invertebrate Species Used To Study Neurotoxicity Of Pfasmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health

Foguth

Sepúlveda

Cannon

2020

Toxics

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Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that were widely used in manufacturing and are now present in the environment throughout the world. It is known that various PFAS are quantifiable in human in blood, but potential adverse health outcomes remain unclear. Sentinel and non-traditional model species are useful to study potential toxicity of PFAS in order to understand the relationship between environmental and human health. Here, we present a critical review of studies on the neurotoxicity of PFAS in sentinel and non-traditional laboratory model systems, including Caenorhabditis elegans (nematode), Dugesia japonica (planarian), Rana pipiens (frogs), Danio rerio and Oryzias melastigma (fish), and Ursus maritimus (polar bears). PFAS have been implicated in developmental neurotoxicity in non-traditional and traditional model systems as well as sentinel species, including effects on neurotransmitter levels, especially acetylcholine and its metabolism. However, further research on the mechanisms of toxicity needs to be conducted to determine if these chemicals are affecting organisms in a similar manner. Overall, findings tend to be similar among the various species, but bioaccumulation may vary, which needs to be taken into account in future studies by quantifying target organ concentrations of PFAS to better compare different species. Furthermore, data on the majority of PFAS is lacking in neurotoxicity testing, and additional studies are needed to corroborate findings thus far.

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“…Dugesia japonica est plus sensible au SDS qu'au Triton X-100 [28]. L'exposition de cette planaire au PFOS provoque des perturbations de la régulation de gènes impliqués dans le neurodéveloppement, une altération de certains neurotransmetteurs comme la dopamine, et une inhibition de l'activité AChE [31].…”

Section: Toxicité Des Composés Pharmaceutiquesunclassified

Modèles alternatifs (6)

et al. 2019

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Depuis quelques dizaines d’années, un nouveau modèle animal invertébré a fait son apparition dans les études toxicologiques : la planaire. Ce ver plat non parasitaire, du phylum des Plathelminthes, possède une incroyable capacité de régénération : il a été décrit comme « immortel sous la lame du couteau » en 1814 par Dalyell. Cette impressionnante capacité est due à l’abondance de cellules souches, appelées néoblastes, qui permettent à un fragment équivalent à 1/279 de la taille de ce ver de générer un animal entier. La planaire dispose d’un système nerveux semblable à celui de l’homme. Elle a ainsi été utilisée pour évaluer les perturbations de développement et la neurotoxicité engendrées par différent composés. Cette revue rassemble les principales études de toxicité réalisées chez la planaire qui illustrent le fort potentiel de ce ver en recherche.

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Perfluorooctane sulfonate induced neurotoxicity responses associated with neural genes expression, neurotransmitter levels and acetylcholinesterase activity in planarians Dugesia japonica

Cited by 40 publications

References 51 publications

Assessing the Ecological Risks of Per‐ and Polyfluoroalkyl Substances: Current State‐of‐the Science and a Proposed Path Forward

Assessing the Ecological Risks of Per‐ and Polyfluoroalkyl Substances: Current State‐of‐the Science and a Proposed Path Forward

Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health

Modèles alternatifs (6)

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