Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte

Shi, Bendong; Zhang, Zhuoqi; Xing, Jiao; Liu, Qiaohan; Cai, Jingzeng; Zhang, Ziwei

doi:10.1016/j.aquatox.2024.106839

Cited by 5 publications

(2 citation statements)

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“…Reactive oxygen species (ROS) are produced by the organism from part of the oxygen taken up by fish respiration. A tiny percentage of ROS control gene expression and cell activity through their involvement in cell signaling pathways (Shi et al, 2024). According to Abdel-Tawwab et al (2019), fish that experience oxidative stress due to excessive ROS production during hypoxia eventually undergo apoptosis and sustain tissue damage.…”

Section: Introductionmentioning

confidence: 99%

The identification of toll-like receptor genes in large yellow croaker (Larimichthys crocea): provides insights into its environmental adaptation to biological and abiotic stresses

Yao,

Miao,

Sun

et al. 2024

Front. Mar. Sci.

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Large yellow croaker (Larimichthys crocea), the most developing fish of China, suffering from both biotic and abiotic stressors. A genome-wide study was performed for the first time to investigate the roles of Toll-like receptor genes in large yellow croaker (LcTLRs) working in hypoxia response and Aeromonas hydrophila infection. 12 TLR genes were identified and annotated, and phylogenetic tree, analysis of structure and motifs demonstrated that TLRs were highly conserved. To further investigate the LcTLRs under environmental stress, expression pattern analysis of hypoxic response and Aeromonas hydrophila infection revealed that there were nine and six members of LcTLRs showing significant differential expression, indicating that they were concerned in hypoxia stress and disease responses. Meanwhile, their expression levels were validated utilizing qPCR. Taken together, a greater appreciation and understanding of TLRs function in the reaction to biotic and abiotic stress would ultimately lead to more efficiently environmental adaptation in large yellow croaker.

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Section: Introductionmentioning

confidence: 99%