Perfluorooctane sulfonate and perfluorooctanoic acid induce plasma membrane dysfunction in boar spermatozoa during in vitro capacitation

Ortiz-Sánchez, Paola Berenice; Roa-Espitia, Ana Lilia; Fierro, Reyna; López-Torres, Aideé S.; Jiménez-Morales, Irma; Oseguera-López, Iván; Hernández‐González, Enrique O.; González‐Márquez, Humberto

doi:10.1016/j.reprotox.2022.03.013

Cited by 8 publications

(26 citation statements)

References 51 publications

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“…Our previous study showed that incubation with PFOA in vitro compromised progesterone-induced acrosome reaction and viscous medium penetration in human sperm ( 43 ). Similarly, in vitro exposure to PFOA and PFOS decreased the number of capacitated spermatozoa and hindered progesterone-induced acrosomal reaction in boar spermatozoa ( 45 , 46 ).…”

Section: Effect Of Pfass On Human Sperm Quality and Quantitymentioning

confidence: 90%

Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence

et al. 2023

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As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca2+ influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa.

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Section: Effect Of Pfass On Human Sperm Quality and Quantitymentioning

confidence: 90%

Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence

et al. 2023

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“…Indeed, PFOA and other PFAS have been shown to alter plasma membrane potential and to acidify cytosol in a human colon carcinoma HCT116 cell model due to their amphipatic structure, suggesting these alterations may precede reactive oxygen species production and mitochondrial transmembrane potential impairment [ 68 ]. Moreover, membrane potential dysregulation and alteration of the organization of membrane microdomains have been reported in boar spermatozoa experimentally exposed to PFOA and perfluorooctane sulfonate (PFOS) [ 69 ]. Recently, exposure of human HepaRG hepatoma cells to PFOA and PFOS has resulted in altered bile canalicular structure and bile flow impairment, caused by actin cytoskeleton disarrangement and to structural redistribution of the tight-junctional protein ZO-1 [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Alterations of the Glomerular Filtration Barrier in Fish Experimentally Exposed to Perfluorooctanoic Acid

Manera

Casciano

Giari

2023

IJERPH

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Per- and polyfluoroalkyl substances can be referred to as the most critical group of contaminants of emerging concern. They can accumulate in high concentration in the kidney and are known to potentially affect its function. Nonetheless, there is a lack of knowledge about their morphopathological effect on the glomerular filtration barrier. Since previous research suggests perfluorooctanoic acid (PFOA) induces glomerular protein leakage, the glomerular filtration barrier of 30 carp from the same parental stock (10 unexposed; 10 exposed to 200 ng L−1 of PFOA; and 10 exposed to 2 mg L−1 of PFOA for 56 days) was screened for possible PFOA-induced ultrastructural lesions in order to shed light on the related pathophysiology. PFOA exposure affected the glomerular filtration barrier in carp experimentally exposed to 2 mg L−1, showing ultrastructural alterations compatible with glomerulonephrosis: podocyte effacement, reduction of filtration slits and filtration slit diaphragms, basement membrane disarrangement, and occurrence of proteinaceous material in the urinary space. The results of the present research confirm the glomerular origin of the PFOA-induced protein leakage and can contribute to the mechanistic comprehension of PFOA’s impact on renal function and to the assessment of the exposure effect of environmental pollutants on animals and humans, according to the One Health approach.

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“…The blood–testis barrier is crossed by PFAS, allowing for direct interaction with sperm [ 18 , 57 , 58 ]. PFOS and PFOA exposure can impact semen quality by coiling sperm tails, impacting the crucial component of sperm motility through the female reproductive tract [ 12 ].…”

Section: Effects On Male Gamete and Fertilization Capabilitymentioning

confidence: 99%

“…The capacitation reaction involves the spermatozoa changes, both physiological and chemical, that occur in the oviduct after ejaculation, preparing the sperm to undergo the acrosomal reaction by releasing lytic enzymes responsible for sperm penetration through the zona pellucida (ZP) and exposing membrane receptors on the sperm head, needed to bind to the ZP ( Figure 4 ) [ 18 , 68 ].…”

Section: Effects On Male Gamete and Fertilization Capabilitymentioning

confidence: 99%

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How Per- and Poly-Fluoroalkyl Substances Affect Gamete Viability and Fertilization Capability: Insights from the Literature

Lockington,

Favetta

2024

JoX

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There has been emerging research linking per- and poly-fluoroalkyl substances (PFAS) to gamete viability and fertility. PFAS, prevalent in the environment and water supplies, undergo slow degradation due to their C-F bond and a long half-life (2.3–8.5 years). In females, PFAS inhibit the hypothalamic–pituitary–gonadal (HPG) axis, reducing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, leading to the inhibition of androgen and estradiol production. PFAS have been found to cause detrimental effects on egg quality through impairing folliculogenesis. In males, PFAS can impair sperm motility and morphology: two fundamental qualities of successful fertilization. PFAS exposure has been proven to inhibit testosterone production, sperm capacitation, and acrosomal reaction. After fertilization, the results of PFAS exposure to embryos have also been investigated, showing reduced development to the blastocyst stage. The aim of this review is to report the main findings in the literature on the impact of PFAS exposure to gamete competency and fertilization capability by highlighting key studies on both male and female fertility. We report that there is significant evidence demonstrating the negative impacts on fertility after PFAS exposure. At high doses, these environmentally abundant and widespread compounds can significantly affect human fertility.

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Perfluorooctane sulfonate and perfluorooctanoic acid induce plasma membrane dysfunction in boar spermatozoa during in vitro capacitation

Cited by 8 publications

References 51 publications

Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence

Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence

Ultrastructural Alterations of the Glomerular Filtration Barrier in Fish Experimentally Exposed to Perfluorooctanoic Acid

How Per- and Poly-Fluoroalkyl Substances Affect Gamete Viability and Fertilization Capability: Insights from the Literature

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