Perfluorooctane Sulfonate and Perfluorooctanoic Acid in Surgical Thyroid Specimens of Patients with Thyroid Diseases

Pirali, Barbara; Negri, Sara; Chytiris, Spyridon; Perissi, Andrea; Villani, Laura; Manna, Luigi La; Cottica, Danilo; Ferrari, Marco; Imbriani, Marcello; Rotondi, Mario; Chiovato, Luca

doi:10.1089/thy.2009.0174

Cited by 24 publications

(17 citation statements)

References 27 publications

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“…20 PFOa has been found in thyroid tissue but does not appear to be actively concentrated there. 33 this study has several strengths. it is the largest study to date of the association between PFOa exposure and thyroid disease and was conducted in a population with a wide range of PFOa exposure levels.…”

Section: Discussionmentioning

confidence: 95%

Perfluorooctanoic Acid Exposure and Thyroid Disease in Community and Worker Cohorts

Winquist

Steenland²

2014

Epidemiology

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Section: Discussionmentioning

confidence: 95%

Perfluorooctanoic Acid Exposure and Thyroid Disease in Community and Worker Cohorts

Winquist

Steenland²

2014

Epidemiology

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“…Analysis of these same plants (N = 506, 93% male) in the year, 2000, also found no associations between thyroid function and PFOA (Olsen and Zobel, 2007b). Another small study (Pirali et al, 2009) of thyroid tissue in 28 patients with thyroid disease found no significant association of intrathyroidal concentrations of PFOA or PFOS and underlying thyroid disease when compared with thyroid tissue from autopsy controls. However, the National Health and Nutrition Examination Survey (NHANES) study using a larger probability-based sample reported significantly higher odds of self-reported thyroid disease in women in the upper quartile of serum PFOA levels compared with those in lower quartiles and a similar near significant trend in men (Melzer et al, 2010).…”

Section: Introductionmentioning

confidence: 88%

Perfluorocarbon exposure, gender and thyroid function in the C8 Health Project

et al. 2011

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Perfluorocarbons from common household products such as food containers, stain- resistant protection for clothing, furniture and carpets, paints, and fire-fighting foams are found in soil, water, plants, animal and human serum worldwide. Previous research has shown a significant association between these chemicals and thyroid disease in women. The present data from the C8 Health Project assessed thyroid function in a cross-sectional analysis of 52,296 adults with a year or more of exposure to perfluorooctanoate (PFOA) from drinking water. Outcomes were: thyroxine, T3 uptake, and thyroid stimulating hormone (TSH). Analyses were stratified by gender and age group (< 20 - < 50 years and > 50). Both PFOA and perfluorooctane sulfonate (PFOS) were associated with significant elevations in serum thyroxine and a significant reduction in T3 uptake in all participants. There were also significant gender/PFOS interactions for T3( )uptake and thyroxine, as well as gender/PFOA interactions for T3 uptake. Results provide evidence for disruption of thyroid function related to these common chemicals and possible mechanisms are discussed.

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“…Based on possible effects of PFCs on the thyroid, Pirali et al [262] examined PFOS and PFOA in surgical thyroid samples from patients with diseases of the thyroid. The substances were detected in all samples.…”

Section: Studies On Biochemical Parameters and Mortality Ratesmentioning

confidence: 99%

Toxicology of perfluorinated compounds

2011

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Perfluorinated compounds [PFCs] have found a wide use in industrial products and processes and in a vast array of consumer products. PFCs are molecules made up of carbon chains to which fluorine atoms are bound. Due to the strength of the carbon/fluorine bond, the molecules are chemically very stable and are highly resistant to biological degradation; therefore, they belong to a class of compounds that tend to persist in the environment. These compounds can bioaccumulate and also undergo biomagnification. Within the class of PFC chemicals, perfluorooctanoic acid and perfluorosulphonic acid are generally considered reference substances. Meanwhile, PFCs can be detected almost ubiquitously, e.g., in water, plants, different kinds of foodstuffs, in animals such as fish, birds, in mammals, as well as in human breast milk and blood. PFCs are proposed as a new class of 'persistent organic pollutants'. Numerous publications allude to the negative effects of PFCs on human health. The following review describes both external and internal exposures to PFCs, the toxicokinetics (uptake, distribution, metabolism, excretion), and the toxicodynamics (acute toxicity, subacute and subchronic toxicities, chronic toxicity including carcinogenesis, genotoxicity and epigenetic effects, reproductive and developmental toxicities, neurotoxicity, effects on the endocrine system, immunotoxicity and potential modes of action, combinational effects, and epidemiological studies on perfluorinated compounds).

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Perfluorooctane Sulfonate and Perfluorooctanoic Acid in Surgical Thyroid Specimens of Patients with Thyroid Diseases

Cited by 24 publications

References 27 publications

Perfluorooctanoic Acid Exposure and Thyroid Disease in Community and Worker Cohorts

Perfluorooctanoic Acid Exposure and Thyroid Disease in Community and Worker Cohorts

Perfluorocarbon exposure, gender and thyroid function in the C8 Health Project

Toxicology of perfluorinated compounds

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