Perfluorochemicals and Photodynamic Therapy in Mice

Iodinated hydroxyphenyl and hydroxynaphthyl porphyrins as tumour localisers

“…The fact that the blood activity was in general equal to or higher than the tumour activity tends to suggest that the phototherapeutic effects of these compounds may be due to their intrinsically high quantum yield and mediated via the destruction of the blood supply to the tumours. It should be borne in mind that the present porphyrins, being iodinated, may have different distributions from the non-iodinated compounds used by Berenbaum et al (1986). However, iodination did not appear to significantly alter their solubility, lipophilicity and spectral characteristics.…”

“…In view of the high efficiency in inducing tumour necrosis during phototherapy, as reported by Berenbaum et al (1986), it was surprising to find that so little of the compounds were actually taken up by the tumours. The fact that the blood activity was in general equal to or higher than the tumour activity tends to suggest that the phototherapeutic effects of these compounds may be due to their intrinsically high quantum yield and mediated via the destruction of the blood supply to the tumours.…”

“…An ideal agent for phototherapy should have good selectivity for neoplastic tissues, a high yield of reactive species such as singlet oxygen (Bown et al, 1986) and long wavelength stimulation for deeper tissue penetration. Berenbaum et al (1986) showed that the synthetic meso-tetra (hydroxyphenyl) porphyrins appeared to satisfy most of these requirements. These authors, however, quantitated the effectiveness of their compounds by their relative ability to induce necrosis in transplanted animal tumours after irradiation with light of the appropriate wavelength.…”

Synthetic Oxygen Transport Fluids Based on Perfluorochemicals: Applications in Medicine and Biology

“…Experiments have shown that incubation of porphyrin de rivatives with either FC-43 or FDC emulsified with Pluronic F-68 can increase the efficiency of photosensitised histi dine oxidation [87]. However, while PFCs appear to be of no immediate benefit in animals receiving PDT while breathing air [88,89], it has been shown that emulsified FDC may nevertheless protect skin against PDT-induced damage [89].…”

The significance of the nature of the photosensitizer for photodynamic therapy: quantitative and biological studies in the colon

“…For clinical PDT it is generally necessary to use a wavelength at the red end of the spectrum in order to get adequate tissue penetration of light. There are a few studies that directly compare the effectiveness of different photosensitisers (Berenbaum et al, 1986), but no quantitative comparison of prophyrins and phthalocyanines.…”